ENSG00000169660

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337014 ENSG00000169660 HEK293_OSMI2_2hA HEK293_TMG_2hB HEXD protein_coding protein_coding 20.39204 29.72981 12.80424 1.056332 0.2789268 -1.214648 4.506131 6.429183 3.0833205 0.5760216 0.46815833 -1.0577213 0.21394167 0.21556667 0.23970000 0.024133333 8.363800e-01 7.421983e-40 FALSE TRUE
ENST00000583978 ENSG00000169660 HEK293_OSMI2_2hA HEK293_TMG_2hB HEXD protein_coding retained_intron 20.39204 29.72981 12.80424 1.056332 0.2789268 -1.214648 3.399452 4.447186 2.8285401 0.5371166 0.07272607 -0.6509841 0.18894167 0.15116667 0.22130000 0.070133333 2.135075e-01 7.421983e-40   FALSE
ENST00000585077 ENSG00000169660 HEK293_OSMI2_2hA HEK293_TMG_2hB HEXD protein_coding retained_intron 20.39204 29.72981 12.80424 1.056332 0.2789268 -1.214648 1.447054 0.000000 1.2868094 0.0000000 0.23962430 7.0188227 0.07899583 0.00000000 0.10000000 0.100000000 8.992495e-19 7.421983e-40 FALSE TRUE
ENST00000644009 ENSG00000169660 HEK293_OSMI2_2hA HEK293_TMG_2hB HEXD protein_coding protein_coding 20.39204 29.72981 12.80424 1.056332 0.2789268 -1.214648 3.123623 10.281471 0.0000000 0.4955919 0.00000000 -10.0072335 0.11083333 0.34753333 0.00000000 -0.347533333 7.421983e-40 7.421983e-40 FALSE TRUE
ENST00000644886 ENSG00000169660 HEK293_OSMI2_2hA HEK293_TMG_2hB HEXD protein_coding retained_intron 20.39204 29.72981 12.80424 1.056332 0.2789268 -1.214648 2.405182 1.845884 2.2617028 0.3019957 0.18319628 0.2916674 0.13043750 0.06160000 0.17620000 0.114600000 3.182766e-07 7.421983e-40 FALSE TRUE
MSTRG.15351.14 ENSG00000169660 HEK293_OSMI2_2hA HEK293_TMG_2hB HEXD protein_coding   20.39204 29.72981 12.80424 1.056332 0.2789268 -1.214648 1.213601 1.876699 0.8117783 0.4167371 0.04377534 -1.1990429 0.06177500 0.06233333 0.06350000 0.001166667 9.791013e-01 7.421983e-40 TRUE TRUE
MSTRG.15351.23 ENSG00000169660 HEK293_OSMI2_2hA HEK293_TMG_2hB HEXD protein_coding   20.39204 29.72981 12.80424 1.056332 0.2789268 -1.214648 1.188138 1.275507 0.6484471 0.2440420 0.13461273 -0.9651984 0.05751250 0.04243333 0.05033333 0.007900000 8.187321e-01 7.421983e-40 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169660 E001 0.000000       17 82418318 82418346 29 +      
ENSG00000169660 E002 34.810961 0.0386198864 1.986462e-08 2.317869e-07 17 82418347 82418660 314 + 1.861 1.238 -2.135
ENSG00000169660 E003 7.533105 0.0022870918 1.684982e-14 5.375798e-13 17 82418661 82418672 12 + 1.354 0.457 -3.531
ENSG00000169660 E004 7.856669 0.0021297357 7.970162e-09 1.000943e-07 17 82418673 82418686 14 + 1.283 0.620 -2.518
ENSG00000169660 E005 7.004282 0.0023742490 1.873841e-06 1.466915e-05 17 82418687 82418689 3 + 1.198 0.620 -2.218
ENSG00000169660 E006 8.636842 0.0019596253 8.263780e-06 5.595041e-05 17 82418690 82418696 7 + 1.242 0.739 -1.879
ENSG00000169660 E007 10.397636 0.0017068086 1.125219e-05 7.388373e-05 17 82418697 82418712 16 + 1.295 0.831 -1.696
ENSG00000169660 E008 10.618992 0.0016196955 1.458684e-04 7.293692e-04 17 82418713 82418715 3 + 1.270 0.866 -1.473
ENSG00000169660 E009 17.777891 0.0010413072 3.352636e-05 1.969875e-04 17 82418716 82418740 25 + 1.442 1.080 -1.277
ENSG00000169660 E010 41.915438 0.0005181777 1.460172e-02 3.959878e-02 17 82419749 82419799 51 + 1.667 1.505 -0.552
ENSG00000169660 E011 90.315168 0.0013154490 2.039190e-02 5.230911e-02 17 82419800 82419883 84 + 1.966 1.847 -0.398
ENSG00000169660 E012 54.334361 0.0118473643 3.791333e-04 1.693962e-03 17 82419884 82420296 413 + 1.857 1.589 -0.906
ENSG00000169660 E013 36.814919 0.0102417184 6.703294e-02 1.384349e-01 17 82420297 82420496 200 + 1.616 1.458 -0.542
ENSG00000169660 E014 4.326276 0.0101016094 4.813535e-01 6.195896e-01 17 82423310 82423599 290 + 0.744 0.621 -0.517
ENSG00000169660 E015 58.797447 0.0021417589 5.021594e-02 1.095367e-01 17 82424394 82424418 25 + 1.787 1.664 -0.416
ENSG00000169660 E016 111.789747 0.0004042706 3.062774e-01 4.484319e-01 17 82424419 82424503 85 + 2.009 1.952 -0.189
ENSG00000169660 E017 1.358776 0.0096765512 4.598970e-01 5.999635e-01 17 82428030 82428127 98 + 0.432 0.286 -0.868
ENSG00000169660 E018 138.078415 0.0002969357 1.658120e-01 2.827594e-01 17 82428558 82428645 88 + 2.104 2.039 -0.217
ENSG00000169660 E019 151.507510 0.0002341438 4.391580e-01 5.809208e-01 17 82433658 82433799 142 + 2.086 2.095 0.029
ENSG00000169660 E020 83.841467 0.0005203028 4.377032e-01 5.796156e-01 17 82433800 82433822 23 + 1.821 1.840 0.062
ENSG00000169660 E021 179.951006 0.0002976787 4.282622e-07 3.838798e-06 17 82435689 82435872 184 + 2.044 2.194 0.504
ENSG00000169660 E022 104.543190 0.0003076519 4.716812e-03 1.514219e-02 17 82436667 82436728 62 + 1.850 1.953 0.344
ENSG00000169660 E023 60.918334 0.0004890815 1.887514e-02 4.906004e-02 17 82436729 82436738 10 + 1.610 1.723 0.385
ENSG00000169660 E024 33.921763 0.0021128521 2.223749e-18 1.172836e-16 17 82436739 82437126 388 + 1.821 1.255 -1.941
ENSG00000169660 E025 11.791701 0.0016556752 2.679555e-07 2.504483e-06 17 82437127 82437167 41 + 1.375 0.866 -1.841
ENSG00000169660 E026 86.542201 0.0003863178 3.132652e-04 1.433717e-03 17 82437168 82437214 47 + 1.726 1.881 0.522
ENSG00000169660 E027 138.951785 0.0002739051 1.110281e-03 4.337637e-03 17 82437215 82437363 149 + 1.974 2.076 0.343
ENSG00000169660 E028 110.149213 0.0003901510 1.087729e-06 8.958652e-06 17 82439631 82439713 83 + 1.799 1.992 0.652
ENSG00000169660 E029 32.633519 0.0063588001 6.402805e-07 5.543080e-06 17 82439714 82439999 286 + 1.698 1.321 -1.292
ENSG00000169660 E030 23.949221 0.0145892280 1.341916e-03 5.116197e-03 17 82440000 82440113 114 + 1.531 1.217 -1.087
ENSG00000169660 E031 18.574888 0.0175110865 6.391376e-04 2.676985e-03 17 82440114 82440173 60 + 1.451 1.093 -1.259
ENSG00000169660 E032 19.107290 0.0315842035 4.708297e-03 1.512044e-02 17 82440174 82440262 89 + 1.450 1.116 -1.174
ENSG00000169660 E033 18.279235 0.0152106139 6.623355e-05 3.619090e-04 17 82440263 82440334 72 + 1.476 1.070 -1.429
ENSG00000169660 E034 19.069997 0.0098828157 5.153510e-07 4.546719e-06 17 82440335 82440472 138 + 1.530 1.061 -1.647
ENSG00000169660 E035 25.478634 0.0017022721 1.935082e-08 2.263355e-07 17 82440473 82440613 141 + 1.622 1.203 -1.452
ENSG00000169660 E036 126.886500 0.0005530798 6.207654e-04 2.609206e-03 17 82440997 82441070 74 + 1.927 2.044 0.394
ENSG00000169660 E037 71.055014 0.0038264256 7.874690e-04 3.214403e-03 17 82441071 82441075 5 + 1.622 1.809 0.633
ENSG00000169660 E038 55.188843 0.0005152555 2.366291e-02 5.911655e-02 17 82441076 82441152 77 + 1.572 1.686 0.389
ENSG00000169660 E039 35.933106 0.0006005965 1.137520e-01 2.109971e-01 17 82441153 82441164 12 + 1.405 1.500 0.326
ENSG00000169660 E040 143.802389 0.0002313496 8.943229e-07 7.503401e-06 17 82441165 82441266 102 + 1.938 2.102 0.551
ENSG00000169660 E041 12.659065 0.0025400381 2.263798e-02 5.699806e-02 17 82441744 82441799 56 + 1.228 0.982 -0.888
ENSG00000169660 E042 93.729258 0.0003063156 4.353902e-03 1.413258e-02 17 82441800 82441820 21 + 1.799 1.909 0.371
ENSG00000169660 E043 138.030812 0.0002857315 9.606062e-08 9.785136e-07 17 82441821 82441889 69 + 1.903 2.089 0.626
ENSG00000169660 E044 225.383697 0.0002246002 8.833673e-15 2.928856e-13 17 82442177 82442645 469 + 2.088 2.305 0.725