ENSG00000169604

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000303714 ENSG00000169604 HEK293_OSMI2_2hA HEK293_TMG_2hB ANTXR1 protein_coding protein_coding 18.14008 12.0744 24.85975 0.2912699 0.4078154 1.041246 15.2428369 9.72344331 20.4379167 0.24673332 0.63623860 1.0709317 0.84081250 0.80563333 0.82326667 0.01763333 8.694724e-01 2.054888e-05 FALSE  
ENST00000409829 ENSG00000169604 HEK293_OSMI2_2hA HEK293_TMG_2hB ANTXR1 protein_coding protein_coding 18.14008 12.0744 24.85975 0.2912699 0.4078154 1.041246 0.9695482 1.13224295 0.9763776 0.07356488 0.03932455 -0.2116576 0.06243333 0.09376667 0.03926667 -0.05450000 4.874923e-05 2.054888e-05 FALSE  
ENST00000463335 ENSG00000169604 HEK293_OSMI2_2hA HEK293_TMG_2hB ANTXR1 protein_coding protein_coding 18.14008 12.0744 24.85975 0.2912699 0.4078154 1.041246 0.6763579 1.03213518 0.5911259 0.13305871 0.09906174 -0.7938032 0.04485833 0.08523333 0.02373333 -0.06150000 2.054888e-05 2.054888e-05 FALSE  
MSTRG.18570.5 ENSG00000169604 HEK293_OSMI2_2hA HEK293_TMG_2hB ANTXR1 protein_coding   18.14008 12.0744 24.85975 0.2912699 0.4078154 1.041246 0.9641699 0.01417054 2.1514912 0.01417054 1.13231041 6.4826337 0.03713333 0.00120000 0.08510000 0.08390000 2.975639e-01 2.054888e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169604 E001 0.5848434 0.0235707263 1.714100e-01 2.900290e-01 2 69013176 69013178 3 + 0.248 0.000 -11.472
ENSG00000169604 E002 2.5474932 0.0060768395 5.795836e-02 1.231346e-01 2 69013179 69013305 127 + 0.589 0.323 -1.386
ENSG00000169604 E003 2.8409591 0.0053372376 1.190888e-01 2.186403e-01 2 69013306 69013356 51 + 0.610 0.424 -0.895
ENSG00000169604 E004 17.8182720 0.0076304666 9.523246e-02 1.832201e-01 2 69013357 69013396 40 + 1.248 1.201 -0.166
ENSG00000169604 E005 34.4786975 0.0080128520 6.287958e-02 1.315092e-01 2 69013397 69013439 43 + 1.517 1.490 -0.094
ENSG00000169604 E006 48.7138009 0.0056644671 4.727252e-02 1.043221e-01 2 69013440 69013499 60 + 1.660 1.649 -0.038
ENSG00000169604 E007 92.6874339 0.0056522998 9.937034e-03 2.860483e-02 2 69013500 69013651 152 + 1.938 1.918 -0.066
ENSG00000169604 E008 51.4714908 0.0039534526 4.435457e-03 1.435916e-02 2 69040044 69040048 5 + 1.695 1.639 -0.192
ENSG00000169604 E009 88.3246239 0.0016632785 3.509736e-06 2.588000e-05 2 69040049 69040115 67 + 1.937 1.845 -0.311
ENSG00000169604 E010 98.7515685 0.0004058817 1.826934e-06 1.433572e-05 2 69044742 69044813 72 + 1.980 1.911 -0.232
ENSG00000169604 E011 0.4460135 0.0301334067 2.866943e-01 4.271229e-01 2 69044814 69049227 4414 + 0.198 0.000 -13.219
ENSG00000169604 E012 112.0143118 0.0158199133 2.169495e-02 5.503982e-02 2 69070647 69070728 82 + 2.023 1.989 -0.116
ENSG00000169604 E013 82.5539935 0.0044112627 9.085968e-03 2.649554e-02 2 69071754 69071787 34 + 1.887 1.869 -0.060
ENSG00000169604 E014 103.4398833 0.0004256342 1.175390e-02 3.294385e-02 2 69073022 69073101 80 + 1.971 1.996 0.084
ENSG00000169604 E015 101.4328021 0.0003241186 7.775897e-04 3.178528e-03 2 69075590 69075658 69 + 1.972 1.964 -0.028
ENSG00000169604 E016 0.2987644 0.0272757513 5.068048e-01   2 69075659 69077407 1749 + 0.141 0.000 -12.674
ENSG00000169604 E017 113.8134993 0.0003869001 8.065148e-05 4.310187e-04 2 69077408 69077488 81 + 2.027 2.003 -0.079
ENSG00000169604 E018 0.0000000       2 69086179 69089377 3199 +      
ENSG00000169604 E019 0.0000000       2 69090646 69090858 213 +      
ENSG00000169604 E020 95.2899285 0.0003071225 5.719196e-04 2.428739e-03 2 69090859 69090919 61 + 1.949 1.934 -0.051
ENSG00000169604 E021 0.1451727 0.0433799154 1.000000e+00   2 69090920 69091098 179 + 0.076 0.000 -11.511
ENSG00000169604 E022 113.3046460 0.0002730749 4.699764e-03 1.509513e-02 2 69102842 69102940 99 + 2.014 2.033 0.066
ENSG00000169604 E023 17.1250081 0.0055110053 2.130527e-18 1.126492e-16 2 69102941 69103444 504 + 0.734 1.647 3.296
ENSG00000169604 E024 91.2973602 0.0002810116 1.888727e-05 1.178181e-04 2 69123017 69123086 70 + 1.941 1.887 -0.181
ENSG00000169604 E025 95.7199996 0.0003121622 8.850409e-06 5.956035e-05 2 69124565 69124643 79 + 1.962 1.905 -0.192
ENSG00000169604 E026 1.6197738 0.1087083474 3.318631e-02 7.817181e-02 2 69134995 69135169 175 + 0.198 0.682 2.727
ENSG00000169604 E027 4.5578423 0.0038809612 4.661310e-02 1.031408e-01 2 69145326 69145327 2 + 0.567 0.940 1.521
ENSG00000169604 E028 40.3796994 0.0025762961 2.740892e-22 2.251751e-20 2 69145328 69146401 1074 + 1.244 1.944 2.395
ENSG00000169604 E029 93.8565911 0.0003306847 1.164929e-15 4.359784e-14 2 69152169 69152264 96 + 1.993 1.770 -0.750
ENSG00000169604 E030 67.8190012 0.0003961424 4.295168e-12 9.495935e-11 2 69170248 69170289 42 + 1.855 1.627 -0.774
ENSG00000169604 E031 0.8962933 0.1019215618 8.494664e-02 1.673240e-01 2 69170290 69170618 329 + 0.333 0.000 -13.667
ENSG00000169604 E032 0.2934659 0.0296013741 5.726949e-01   2 69172367 69172558 192 + 0.076 0.190 1.519
ENSG00000169604 E033 86.7848793 0.0006036620 1.876484e-16 7.802772e-15 2 69181786 69181881 96 + 1.967 1.709 -0.869
ENSG00000169604 E034 103.4532933 0.0096360639 5.797983e-06 4.067132e-05 2 69182493 69182660 168 + 2.021 1.863 -0.531
ENSG00000169604 E035 58.5515471 0.0042427298 1.733503e-04 8.498263e-04 2 69193335 69193415 81 + 1.763 1.656 -0.362
ENSG00000169604 E036 0.3030308 0.3934046607 6.246165e-01   2 69204588 69204645 58 + 0.142 0.000 -11.456
ENSG00000169604 E037 0.4031496 0.0251555255 6.143943e-02 1.290555e-01 2 69217797 69217846 50 + 0.000 0.323 13.993
ENSG00000169604 E038 0.0000000       2 69224578 69224671 94 +      
ENSG00000169604 E039 1752.1739691 0.0050706631 3.164483e-15 1.121612e-13 2 69245225 69249327 4103 + 3.107 3.374 0.890