ENSG00000169592

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000304516 ENSG00000169592 HEK293_OSMI2_2hA HEK293_TMG_2hB INO80E protein_coding protein_coding 112.0291 198.193 69.15084 9.049 2.067392 -1.518951 14.159651 22.639398 8.923074 1.4687220 0.5009969 -1.3422440 0.12981667 0.11403333 0.12900000 0.01496667 4.027826e-01 4.815037e-18 FALSE TRUE
ENST00000563197 ENSG00000169592 HEK293_OSMI2_2hA HEK293_TMG_2hB INO80E protein_coding protein_coding 112.0291 198.193 69.15084 9.049 2.067392 -1.518951 31.949809 74.707798 10.467265 0.9248788 0.8435200 -2.8341898 0.24825417 0.37876667 0.15230000 -0.22646667 2.451907e-08 4.815037e-18 FALSE TRUE
ENST00000567254 ENSG00000169592 HEK293_OSMI2_2hA HEK293_TMG_2hB INO80E protein_coding protein_coding 112.0291 198.193 69.15084 9.049 2.067392 -1.518951 5.876158 4.451210 5.503339 0.5175666 0.2492378 0.3054915 0.06766250 0.02233333 0.07973333 0.05740000 4.815037e-18 4.815037e-18 FALSE TRUE
ENST00000568043 ENSG00000169592 HEK293_OSMI2_2hA HEK293_TMG_2hB INO80E protein_coding retained_intron 112.0291 198.193 69.15084 9.049 2.067392 -1.518951 14.680695 22.551462 11.711212 1.2215474 0.5400073 -0.9447388 0.13812917 0.11373333 0.16980000 0.05606667 1.188450e-03 4.815037e-18 FALSE FALSE
ENST00000569957 ENSG00000169592 HEK293_OSMI2_2hA HEK293_TMG_2hB INO80E protein_coding retained_intron 112.0291 198.193 69.15084 9.049 2.067392 -1.518951 6.338109 5.780556 3.317176 0.4705044 0.3689111 -0.7994036 0.06583750 0.02913333 0.04780000 0.01866667 8.605786e-03 4.815037e-18 TRUE FALSE
ENST00000620599 ENSG00000169592 HEK293_OSMI2_2hA HEK293_TMG_2hB INO80E protein_coding protein_coding 112.0291 198.193 69.15084 9.049 2.067392 -1.518951 24.087563 44.896505 18.720930 5.6380211 2.6965941 -1.2615019 0.21275833 0.22510000 0.26923333 0.04413333 6.687469e-01 4.815037e-18 FALSE TRUE
MSTRG.12428.6 ENSG00000169592 HEK293_OSMI2_2hA HEK293_TMG_2hB INO80E protein_coding   112.0291 198.193 69.15084 9.049 2.067392 -1.518951 5.661790 6.538048 3.761723 0.3530599 0.2529058 -0.7958413 0.05654583 0.03303333 0.05460000 0.02156667 6.033615e-03 4.815037e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169592 E001 260.97295 7.702444e-03 1.409207e-04 7.075052e-04 16 29995715 29996209 495 + 2.452 2.274 -0.596
ENSG00000169592 E002 53.80668 4.155951e-03 2.465247e-02 6.116642e-02 16 29996210 29996217 8 + 1.742 1.607 -0.459
ENSG00000169592 E003 114.13775 1.041668e-03 3.653309e-04 1.640029e-03 16 29996218 29996237 20 + 2.065 1.926 -0.467
ENSG00000169592 E004 117.52819 2.159934e-03 1.221884e-03 4.714697e-03 16 29996238 29996240 3 + 2.074 1.939 -0.451
ENSG00000169592 E005 132.61155 1.695048e-03 1.705812e-03 6.300785e-03 16 29996241 29996243 3 + 2.116 1.995 -0.404
ENSG00000169592 E006 133.29406 1.936520e-03 7.506564e-04 3.081465e-03 16 29996244 29996245 2 + 2.126 1.994 -0.441
ENSG00000169592 E007 137.23792 2.399035e-03 7.043530e-04 2.914629e-03 16 29996246 29996246 1 + 2.141 2.006 -0.453
ENSG00000169592 E008 152.03289 2.716390e-03 8.859449e-05 4.684331e-04 16 29996247 29996249 3 + 2.199 2.045 -0.517
ENSG00000169592 E009 159.76958 3.163129e-03 2.417243e-04 1.140628e-03 16 29996250 29996250 1 + 2.216 2.069 -0.491
ENSG00000169592 E010 198.55683 6.004661e-03 2.880030e-02 6.960328e-02 16 29996251 29996251 1 + 2.272 2.176 -0.323
ENSG00000169592 E011 380.60707 2.984734e-03 7.368779e-02 1.494319e-01 16 29996252 29996273 22 + 2.521 2.467 -0.179
ENSG00000169592 E012 1139.38781 6.116140e-04 5.606192e-01 6.885957e-01 16 29996274 29996391 118 + 2.955 2.953 -0.006
ENSG00000169592 E013 137.58549 2.675226e-04 4.066405e-07 3.661098e-06 16 29996392 29996546 155 + 2.169 1.999 -0.568
ENSG00000169592 E014 1238.14866 2.619950e-04 8.274037e-01 8.914762e-01 16 29996547 29996617 71 + 2.986 2.990 0.014
ENSG00000169592 E015 14.00426 2.973671e-03 1.286164e-07 1.279256e-06 16 29996618 29996807 190 + 1.420 0.933 -1.743
ENSG00000169592 E016 1223.60751 8.680106e-05 3.031848e-01 4.450791e-01 16 29996808 29996860 53 + 2.968 2.988 0.065
ENSG00000169592 E017 22.51314 8.768133e-04 1.057658e-08 1.297649e-07 16 29999270 29999568 299 + 1.577 1.152 -1.480
ENSG00000169592 E018 1278.48593 6.966557e-04 5.676168e-02 1.210524e-01 16 30000758 30000836 79 + 2.972 3.013 0.134
ENSG00000169592 E019 813.14791 8.054771e-04 2.501675e-05 1.516785e-04 16 30000929 30000970 42 + 2.732 2.826 0.314
ENSG00000169592 E020 1042.86882 5.950118e-04 1.321347e-07 1.311634e-06 16 30000971 30001040 70 + 2.833 2.935 0.337
ENSG00000169592 E021 104.01270 1.870329e-03 2.164499e-03 7.733731e-03 16 30001212 30001413 202 + 2.017 1.887 -0.436
ENSG00000169592 E022 601.84532 9.019359e-04 1.649550e-08 1.953261e-07 16 30001414 30001464 51 + 2.562 2.703 0.470
ENSG00000169592 E023 522.28814 7.679883e-04 4.154041e-10 6.603743e-09 16 30001465 30001530 66 + 2.485 2.644 0.530
ENSG00000169592 E024 202.95000 2.784270e-04 2.233338e-44 1.004986e-41 16 30001531 30002435 905 + 2.476 2.102 -1.248
ENSG00000169592 E025 140.84182 6.175813e-03 2.415651e-06 1.845835e-05 16 30002436 30003013 578 + 2.227 1.994 -0.781
ENSG00000169592 E026 99.86055 9.718159e-03 1.862666e-05 1.163956e-04 16 30003014 30003435 422 + 2.091 1.836 -0.856
ENSG00000169592 E027 62.50862 2.683984e-03 1.310589e-03 5.012358e-03 16 30003436 30003526 91 + 1.832 1.660 -0.581
ENSG00000169592 E028 79.68679 4.642389e-03 3.282107e-04 1.493635e-03 16 30003527 30003649 123 + 1.949 1.761 -0.635
ENSG00000169592 E029 46.00284 3.643856e-03 8.181661e-06 5.544594e-05 16 30003650 30003670 21 + 1.774 1.502 -0.925
ENSG00000169592 E030 58.30704 9.773935e-03 5.761081e-03 1.798424e-02 16 30003671 30003714 44 + 1.812 1.629 -0.619
ENSG00000169592 E031 240.08873 2.024385e-04 1.291346e-16 5.482779e-15 16 30003715 30004554 840 + 2.438 2.228 -0.700
ENSG00000169592 E032 31.68687 1.004420e-03 1.554015e-01 2.689329e-01 16 30004555 30004567 13 + 1.485 1.387 -0.336
ENSG00000169592 E033 81.66079 3.469158e-04 1.842515e-01 3.065686e-01 16 30004568 30004657 90 + 1.858 1.802 -0.188
ENSG00000169592 E034 473.31091 1.713392e-04 1.279177e-18 6.949705e-17 16 30005221 30005351 131 + 2.401 2.606 0.684
ENSG00000169592 E035 165.27103 2.214161e-04 2.878281e-03 9.905569e-03 16 30005352 30005367 16 + 2.025 2.138 0.379
ENSG00000169592 E036 1302.80259 1.813346e-03 1.760042e-11 3.517243e-10 16 30005368 30006303 936 + 2.876 3.041 0.548