ENSG00000169554

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000409487 ENSG00000169554 HEK293_OSMI2_2hA HEK293_TMG_2hB ZEB2 protein_coding protein_coding 2.303822 0.7889989 3.440735 0.07019714 0.09810524 2.110638 0.37701365 0.32703558 0.6057875 0.04494571 0.34146665 0.8695318 0.19536250 0.4289000 0.17116667 -0.25773333 4.425893e-01 1.908888e-06 FALSE TRUE
ENST00000440875 ENSG00000169554 HEK293_OSMI2_2hA HEK293_TMG_2hB ZEB2 protein_coding protein_coding 2.303822 0.7889989 3.440735 0.07019714 0.09810524 2.110638 0.29288600 0.00000000 0.2033036 0.00000000 0.20330365 4.4148367 0.12277917 0.0000000 0.05746667 0.05746667 1.000000e+00 1.908888e-06 FALSE TRUE
ENST00000539609 ENSG00000169554 HEK293_OSMI2_2hA HEK293_TMG_2hB ZEB2 protein_coding protein_coding 2.303822 0.7889989 3.440735 0.07019714 0.09810524 2.110638 0.13237967 0.00000000 0.2538418 0.00000000 0.16479417 4.7216011 0.03669583 0.0000000 0.07343333 0.07343333 5.318773e-01 1.908888e-06 FALSE TRUE
ENST00000558170 ENSG00000169554 HEK293_OSMI2_2hA HEK293_TMG_2hB ZEB2 protein_coding protein_coding 2.303822 0.7889989 3.440735 0.07019714 0.09810524 2.110638 0.70981411 0.01025842 1.1736236 0.01025842 0.11254538 5.8685450 0.21797500 0.0147000 0.34160000 0.32690000 1.908888e-06 1.908888e-06 FALSE TRUE
ENST00000629520 ENSG00000169554 HEK293_OSMI2_2hA HEK293_TMG_2hB ZEB2 protein_coding protein_coding 2.303822 0.7889989 3.440735 0.07019714 0.09810524 2.110638 0.09306394 0.08354364 0.1505171 0.04207151 0.03068145 0.7790155 0.05310833 0.1038667 0.04436667 -0.05950000 6.183093e-01 1.908888e-06   FALSE
ENST00000647488 ENSG00000169554 HEK293_OSMI2_2hA HEK293_TMG_2hB ZEB2 protein_coding protein_coding 2.303822 0.7889989 3.440735 0.07019714 0.09810524 2.110638 0.05102323 0.11907073 0.0000000 0.11907073 0.00000000 -3.6900900 0.02548333 0.1284333 0.00000000 -0.12843333 4.912173e-01 1.908888e-06 FALSE TRUE
ENST00000675069 ENSG00000169554 HEK293_OSMI2_2hA HEK293_TMG_2hB ZEB2 protein_coding protein_coding 2.303822 0.7889989 3.440735 0.07019714 0.09810524 2.110638 0.07793827 0.00000000 0.2067501 0.00000000 0.20675007 4.4379606 0.04994167 0.0000000 0.05840000 0.05840000 1.000000e+00 1.908888e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169554 E001 0.0000000       2 144364364 144365626 1263 -      
ENSG00000169554 E002 14.4525462 0.0148351840 5.447273e-02 1.170830e-01 2 144384081 144388015 3935 - 1.054 1.292 0.846
ENSG00000169554 E003 1.1135859 0.0113333968 6.977252e-01 7.977858e-01 2 144388016 144388017 2 - 0.291 0.222 -0.516
ENSG00000169554 E004 6.0502831 0.0570229667 1.707904e-01 2.891968e-01 2 144388018 144388133 116 - 0.711 0.955 0.951
ENSG00000169554 E005 12.2093598 0.0813421682 5.522206e-04 2.355273e-03 2 144388134 144388309 176 - 0.838 1.417 2.093
ENSG00000169554 E006 6.3956035 0.0763199580 1.360190e-03 5.177182e-03 2 144388310 144388340 31 - 0.604 1.156 2.139
ENSG00000169554 E007 15.8412199 0.0304243983 3.068833e-04 1.407464e-03 2 144388341 144388661 321 - 1.010 1.457 1.583
ENSG00000169554 E008 11.0301073 0.0017578506 1.719901e-02 4.538214e-02 2 144388662 144388779 118 - 0.936 1.213 1.006
ENSG00000169554 E009 12.4121917 0.0572834243 5.978936e-02 1.262558e-01 2 144388780 144388882 103 - 0.976 1.260 1.023
ENSG00000169554 E010 15.7075431 0.0065525329 8.532206e-03 2.511890e-02 2 144388883 144389212 330 - 1.072 1.348 0.979
ENSG00000169554 E011 9.2743470 0.0019312148 3.764787e-01 5.208055e-01 2 144389213 144389284 72 - 0.911 1.041 0.483
ENSG00000169554 E012 6.4802908 0.0026350070 5.803334e-01 7.051071e-01 2 144389285 144389316 32 - 0.784 0.884 0.390
ENSG00000169554 E013 26.0430232 0.0026301156 1.395185e-02 3.811136e-02 2 144389317 144389753 437 - 1.299 1.510 0.728
ENSG00000169554 E014 11.2237822 0.0186034097 1.075438e-01 2.019095e-01 2 144389754 144389865 112 - 0.960 1.175 0.781
ENSG00000169554 E015 17.5968188 0.0118293584 9.565112e-01 9.767375e-01 2 144389866 144390028 163 - 1.185 1.214 0.102
ENSG00000169554 E016 0.0000000       2 144390552 144390601 50 -      
ENSG00000169554 E017 0.0000000       2 144394393 144394480 88 -      
ENSG00000169554 E018 19.4213686 0.0232869294 3.561151e-01 5.005041e-01 2 144396412 144396592 181 - 1.248 1.160 -0.310
ENSG00000169554 E019 28.1262886 0.0006833301 5.959784e-05 3.294515e-04 2 144398301 144398720 420 - 1.445 1.114 -1.163
ENSG00000169554 E020 14.1810414 0.0013445251 1.200820e-02 3.355087e-02 2 144398721 144398850 130 - 1.157 0.884 -1.002
ENSG00000169554 E021 18.2644726 0.0015576575 2.217244e-02 5.603209e-02 2 144398851 144399079 229 - 1.251 1.041 -0.753
ENSG00000169554 E022 19.0043647 0.0199346079 3.873170e-02 8.868696e-02 2 144399080 144399350 271 - 1.270 1.041 -0.819
ENSG00000169554 E023 24.0592331 0.0010932529 1.368029e-01 2.436303e-01 2 144399351 144399869 519 - 1.348 1.247 -0.354
ENSG00000169554 E024 18.3725616 0.0011110190 2.001234e-03 7.229606e-03 2 144399870 144400270 401 - 1.263 0.954 -1.115
ENSG00000169554 E025 0.0000000       2 144400271 144400345 75 -      
ENSG00000169554 E026 10.4895444 0.0084048012 3.038727e-02 7.272240e-02 2 144401199 144401307 109 - 1.036 0.753 -1.078
ENSG00000169554 E027 0.0000000       2 144401308 144402662 1355 -      
ENSG00000169554 E028 9.7485418 0.0017583884 1.543501e-02 4.147919e-02 2 144403916 144403994 79 - 1.016 0.699 -1.229
ENSG00000169554 E029 7.9642619 0.0188105472 3.713330e-02 8.573265e-02 2 144403995 144404097 103 - 0.943 0.635 -1.231
ENSG00000169554 E030 5.5995053 0.0141732559 4.125379e-02 9.334951e-02 2 144404098 144404130 33 - 0.817 0.476 -1.479
ENSG00000169554 E031 11.8697140 0.0111298570 1.663729e-01 2.834806e-01 2 144404836 144404995 160 - 1.072 0.920 -0.562
ENSG00000169554 E032 5.2318512 0.0032161270 9.637357e-01 9.811053e-01 2 144404996 144405002 7 - 0.723 0.753 0.121
ENSG00000169554 E033 5.8103519 0.0170942926 7.971714e-01 8.705827e-01 2 144405003 144405024 22 - 0.772 0.753 -0.077
ENSG00000169554 E034 0.0000000       2 144405025 144405373 349 -      
ENSG00000169554 E035 6.5885410 0.0060048400 5.156567e-01 6.502974e-01 2 144424796 144424855 60 - 0.827 0.753 -0.293
ENSG00000169554 E036 4.6330652 0.0505661380 6.011897e-01 7.223266e-01 2 144424856 144424864 9 - 0.710 0.634 -0.318
ENSG00000169554 E037 4.3469862 0.0170152168 6.821554e-01 7.856544e-01 2 144424865 144424867 3 - 0.682 0.636 -0.198
ENSG00000169554 E038 0.1817044 0.0432598372 1.071469e-01   2 144424868 144424953 86 - 0.000 0.222 14.479
ENSG00000169554 E039 0.1817044 0.0432598372 1.071469e-01   2 144426513 144429555 3043 - 0.000 0.222 14.479
ENSG00000169554 E040 0.0000000       2 144429556 144429602 47 -      
ENSG00000169554 E041 0.0000000       2 144429603 144429768 166 -      
ENSG00000169554 E042 5.5336250 0.0085461599 2.903670e-01 4.311635e-01 2 144429769 144429787 19 - 0.784 0.636 -0.611
ENSG00000169554 E043 5.5400814 0.0029643158 2.836509e-01 4.238020e-01 2 144429788 144429825 38 - 0.784 0.637 -0.610
ENSG00000169554 E044 9.0625355 0.0018014717 5.524931e-04 2.356045e-03 2 144429826 144429910 85 - 1.009 0.477 -2.205
ENSG00000169554 E045 8.0045981 0.0021389388 3.392921e-05 1.991445e-04 2 144429911 144429981 71 - 0.974 0.222 -3.660
ENSG00000169554 E046 6.6664440 0.0024339150 2.426658e-04 1.144501e-03 2 144429982 144430026 45 - 0.903 0.222 -3.391
ENSG00000169554 E047 0.0000000       2 144430538 144430744 207 -      
ENSG00000169554 E048 0.0000000       2 144430745 144430942 198 -      
ENSG00000169554 E049 0.0000000       2 144430981 144431022 42 -      
ENSG00000169554 E050 0.0000000       2 144455052 144455200 149 -      
ENSG00000169554 E051 0.1451727 0.0438390213 1.000000e+00   2 144461112 144461832 721 - 0.064 0.000 -11.926
ENSG00000169554 E052 1.0286894 0.0121989077 1.017607e-03 4.019652e-03 2 144461833 144462337 505 - 0.064 0.637 4.390
ENSG00000169554 E053 0.0000000       2 144462338 144464078 1741 -      
ENSG00000169554 E054 0.9556140 0.3255040354 1.000000e+00 1.000000e+00 2 144464166 144464342 177 - 0.253 0.226 -0.219
ENSG00000169554 E055 0.2214452 0.0453898934 1.070612e-01   2 144470419 144470498 80 - 0.000 0.222 14.474
ENSG00000169554 E056 0.0000000       2 144478988 144479016 29 -      
ENSG00000169554 E057 0.1472490 0.0449405836 1.000000e+00   2 144482169 144482341 173 - 0.064 0.000 -11.925
ENSG00000169554 E058 0.0000000       2 144497708 144497764 57 -      
ENSG00000169554 E059 0.0000000       2 144503662 144504633 972 -      
ENSG00000169554 E060 0.0000000       2 144507379 144507420 42 -      
ENSG00000169554 E061 0.0000000       2 144511385 144511388 4 -      
ENSG00000169554 E062 0.0000000       2 144511389 144511390 2 -      
ENSG00000169554 E063 8.6228204 0.0021037389 3.955183e-08 4.353850e-07 2 144511391 144513422 2032 - 0.682 1.308 2.341
ENSG00000169554 E064 2.6247055 0.0081202378 1.909169e-03 6.944289e-03 2 144513423 144513797 375 - 0.325 0.845 2.430
ENSG00000169554 E065 0.1482932 0.0411597534 1.085001e-01   2 144513798 144514451 654 - 0.000 0.221 14.483
ENSG00000169554 E066 0.0000000       2 144515949 144516164 216 -      
ENSG00000169554 E067 0.1515154 0.0432729440 1.000000e+00   2 144516336 144516397 62 - 0.064 0.000 -11.927
ENSG00000169554 E068 0.2987644 0.0275147292 1.000000e+00   2 144516458 144516553 96 - 0.120 0.000 -12.855
ENSG00000169554 E069 0.4502799 0.0284000544 6.160820e-01 7.342082e-01 2 144516554 144516761 208 - 0.169 0.000 -13.372
ENSG00000169554 E070 9.1178548 0.0238998814 6.056020e-03 1.875707e-02 2 144517278 144517419 142 - 1.003 0.563 -1.769
ENSG00000169554 E071 1.5680184 0.2512566900 5.427691e-01 6.734826e-01 2 144517420 144517557 138 - 0.387 0.225 -1.084
ENSG00000169554 E072 0.0000000       2 144517612 144517658 47 -      
ENSG00000169554 E073 0.1482932 0.0411597534 1.085001e-01   2 144517659 144517686 28 - 0.000 0.221 14.483
ENSG00000169554 E074 0.0000000       2 144517687 144517745 59 -      
ENSG00000169554 E075 0.0000000       2 144517746 144518026 281 -      
ENSG00000169554 E076 0.1451727 0.0438390213 1.000000e+00   2 144518134 144518292 159 - 0.064 0.000 -11.926
ENSG00000169554 E077 0.8772652 0.1113458430 2.469292e-01 3.823394e-01 2 144518293 144518446 154 - 0.290 0.000 -14.167
ENSG00000169554 E078 0.0000000       2 144518447 144518450 4 -      
ENSG00000169554 E079 1.9197753 0.0071771535 2.127964e-01 3.418351e-01 2 144519939 144520151 213 - 0.463 0.222 -1.517
ENSG00000169554 E080 0.1472490 0.0449405836 1.000000e+00   2 144520152 144520208 57 - 0.064 0.000 -11.925
ENSG00000169554 E081 0.1472490 0.0449405836 1.000000e+00   2 144520209 144520351 143 - 0.064 0.000 -11.925
ENSG00000169554 E082 0.0000000       2 144520352 144520400 49 -      
ENSG00000169554 E083 0.0000000       2 144520556 144521057 502 -