ENSG00000169490

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397070 ENSG00000169490 HEK293_OSMI2_2hA HEK293_TMG_2hB TM2D2 protein_coding protein_coding 50.86908 40.58822 60.75774 7.695759 1.948121 0.5818893 21.897303 19.697128 23.856276 3.4613443 0.8321771 0.2762560 0.44215417 0.4897000 0.3928000 -0.096900000 0.01774926 0.0004822016 FALSE  
ENST00000456397 ENSG00000169490 HEK293_OSMI2_2hA HEK293_TMG_2hB TM2D2 protein_coding protein_coding 50.86908 40.58822 60.75774 7.695759 1.948121 0.5818893 5.426257 4.362681 7.161228 0.8228194 0.2203850 0.7137020 0.10479167 0.1105333 0.1180667 0.007533333 0.87471701 0.0004822016 FALSE  
ENST00000519186 ENSG00000169490 HEK293_OSMI2_2hA HEK293_TMG_2hB TM2D2 protein_coding retained_intron 50.86908 40.58822 60.75774 7.695759 1.948121 0.5818893 5.098557 2.897131 6.374306 1.1988178 0.6038114 1.1349338 0.09793333 0.0652000 0.1052333 0.040033333 0.52800986 0.0004822016 FALSE  
ENST00000522434 ENSG00000169490 HEK293_OSMI2_2hA HEK293_TMG_2hB TM2D2 protein_coding processed_transcript 50.86908 40.58822 60.75774 7.695759 1.948121 0.5818893 15.397884 11.801586 18.679584 2.4488624 1.7879262 0.6620318 0.29653750 0.2884000 0.3062000 0.017800000 0.82888125 0.0004822016    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169490 E001 164.83749 0.0006309746 4.698853e-08 5.097484e-07 8 38988808 38990804 1997 - 2.299 2.140 -0.529
ENSG00000169490 E002 323.13699 0.0001498140 6.530531e-05 3.574040e-04 8 38990805 38990997 193 - 2.478 2.558 0.267
ENSG00000169490 E003 733.67725 0.0004826796 1.193737e-03 4.619452e-03 8 38990998 38991371 374 - 2.848 2.895 0.155
ENSG00000169490 E004 391.17720 0.0001771650 8.496770e-01 9.067182e-01 8 38991372 38991485 114 - 2.601 2.600 -0.003
ENSG00000169490 E005 201.71944 0.0016996286 8.866968e-01 9.315310e-01 8 38991486 38991491 6 - 2.316 2.307 -0.031
ENSG00000169490 E006 186.54626 0.0013858533 9.265023e-01 9.577150e-01 8 38991492 38991493 2 - 2.278 2.278 -0.002
ENSG00000169490 E007 293.34773 0.0001973187 1.828539e-01 3.047651e-01 8 38991494 38991545 52 - 2.489 2.464 -0.082
ENSG00000169490 E008 359.30221 0.0006788389 5.244694e-01 6.579815e-01 8 38993545 38993660 116 - 2.571 2.560 -0.034
ENSG00000169490 E009 11.86575 0.0014216207 1.993953e-06 1.551519e-05 8 38993661 38994036 376 - 1.297 0.818 -1.754
ENSG00000169490 E010 11.02649 0.0016943335 1.482132e-05 9.471274e-05 8 38995119 38995315 197 - 1.263 0.818 -1.633
ENSG00000169490 E011 2.87344 0.0053029183 7.720715e-04 3.157743e-03 8 38995316 38995317 2 - 0.790 0.230 -2.887
ENSG00000169490 E012 202.86398 0.0033153728 4.637715e-01 6.035352e-01 8 38995318 38995368 51 - 2.328 2.306 -0.073
ENSG00000169490 E013 174.01029 0.0013076094 8.000501e-01 8.725144e-01 8 38995369 38995405 37 - 2.254 2.250 -0.012
ENSG00000169490 E014 51.77824 0.0059606083 2.552041e-01 3.920377e-01 8 38995406 38995598 193 - 1.762 1.684 -0.262
ENSG00000169490 E015 32.60415 0.0019253209 9.637340e-01 9.811053e-01 8 38995599 38995693 95 - 1.529 1.533 0.014
ENSG00000169490 E016 22.96158 0.0028361782 8.228722e-02 1.631202e-01 8 38995694 38995794 101 - 1.443 1.312 -0.452
ENSG00000169490 E017 255.29820 0.0002792798 5.164741e-01 6.510378e-01 8 38996213 38996418 206 - 2.410 2.428 0.060
ENSG00000169490 E018 142.24811 0.0056055352 7.937887e-01 8.681948e-01 8 38996419 38996509 91 - 2.158 2.166 0.026
ENSG00000169490 E019 1.40165 0.0101717835 1.066355e-01 2.005876e-01 8 38996593 38996824 232 - 0.206 0.491 1.786