ENSG00000169379

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394222 ENSG00000169379 HEK293_OSMI2_2hA HEK293_TMG_2hB ARL13B protein_coding protein_coding 8.635626 1.554202 16.38352 0.0388853 1.168547 3.389627 2.739188 1.196728 4.891692 0.121298 0.8138097 2.022180 0.4581708 0.7710333 0.3048333 -0.4662 2.632754e-03 2.514996e-23 FALSE TRUE
MSTRG.23316.2 ENSG00000169379 HEK293_OSMI2_2hA HEK293_TMG_2hB ARL13B protein_coding   8.635626 1.554202 16.38352 0.0388853 1.168547 3.389627 4.054657 0.000000 8.437621 0.000000 0.9145310 9.722401 0.2874167 0.0000000 0.5125000 0.5125 2.514996e-23 2.514996e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169379 E001 0.0000000       3 93980139 93980141 3 +      
ENSG00000169379 E002 0.0000000       3 93980142 93980143 2 +      
ENSG00000169379 E003 0.5870335 0.0872812996 8.618110e-01 9.149100e-01 3 93980144 93980151 8 + 0.174 0.000 -9.279
ENSG00000169379 E004 0.5870335 0.0872812996 8.618110e-01 9.149100e-01 3 93980152 93980154 3 + 0.174 0.000 -11.133
ENSG00000169379 E005 1.0611596 0.0138542618 9.248327e-01 9.566561e-01 3 93980155 93980159 5 + 0.240 0.270 0.224
ENSG00000169379 E006 1.2063323 0.0144440215 1.000000e+00 1.000000e+00 3 93980160 93980164 5 + 0.270 0.270 0.002
ENSG00000169379 E007 1.5332094 0.2347297125 5.417490e-01 6.726840e-01 3 93980165 93980169 5 + 0.296 0.436 0.823
ENSG00000169379 E008 18.3377394 0.0010498576 4.618905e-01 6.018020e-01 3 93980170 93980189 20 + 1.155 1.086 -0.246
ENSG00000169379 E009 43.8997752 0.0005784238 8.042256e-01 8.754639e-01 3 93980190 93980317 128 + 1.507 1.505 -0.004
ENSG00000169379 E010 26.4584559 0.0007782938 9.141381e-01 9.496067e-01 3 93980318 93980328 11 + 1.291 1.318 0.094
ENSG00000169379 E011 42.0396691 0.0161408280 8.386710e-01 8.991568e-01 3 93980329 93980423 95 + 1.482 1.518 0.124
ENSG00000169379 E012 36.0777963 0.0007557980 1.715805e-01 2.902658e-01 3 93980424 93980482 59 + 1.436 1.336 -0.347
ENSG00000169379 E013 0.8021360 0.5689655816 5.353067e-01 6.671717e-01 3 93988672 93988711 40 + 0.173 0.277 0.872
ENSG00000169379 E014 0.5858876 0.0199071962 4.929289e-01 6.300268e-01 3 93988859 93989116 258 + 0.136 0.270 1.222
ENSG00000169379 E015 0.1482932 0.0412414169 5.186464e-02   3 93992990 93993268 279 + 0.000 0.269 12.307
ENSG00000169379 E016 41.0423017 0.0005713609 1.746986e-01 2.943159e-01 3 93995874 93995944 71 + 1.491 1.400 -0.315
ENSG00000169379 E017 0.4375944 0.0241663851 1.000000e+00 1.000000e+00 3 93996548 93996562 15 + 0.136 0.000 -11.023
ENSG00000169379 E018 3.0381793 0.0947544479 7.453814e-01 8.334235e-01 3 93996563 93996684 122 + 0.489 0.555 0.315
ENSG00000169379 E019 3.8457917 0.0551143806 7.880284e-01 8.642434e-01 3 93997080 93997136 57 + 0.569 0.644 0.332
ENSG00000169379 E020 4.5268141 0.0116963228 1.099775e-01 2.055110e-01 3 93997247 93997301 55 + 0.569 0.847 1.158
ENSG00000169379 E021 92.9330799 0.0002869421 1.952090e-01 3.202467e-01 3 94003659 94003908 250 + 1.831 1.781 -0.167
ENSG00000169379 E022 1.5175667 0.2138923917 2.329687e-01 3.659576e-01 3 94003909 94005031 1123 + 0.270 0.549 1.558
ENSG00000169379 E023 73.1651059 0.0004399157 6.532758e-01 7.637973e-01 3 94035331 94035436 106 + 1.723 1.715 -0.029
ENSG00000169379 E024 0.9159869 0.0141231145 7.871743e-01 8.636976e-01 3 94035734 94036551 818 + 0.208 0.270 0.487
ENSG00000169379 E025 93.8766628 0.0015649347 3.445940e-01 4.886875e-01 3 94036552 94036754 203 + 1.834 1.800 -0.115
ENSG00000169379 E026 0.3289534 0.0286488910 1.683982e-01   3 94037932 94038018 87 + 0.050 0.270 2.809
ENSG00000169379 E027 60.5361563 0.0004021878 1.971878e-03 7.138531e-03 3 94039880 94039988 109 + 1.668 1.469 -0.682
ENSG00000169379 E028 80.5226185 0.0018772432 8.226929e-03 2.435908e-02 3 94043015 94043240 226 + 1.782 1.636 -0.495
ENSG00000169379 E029 1.4726265 0.0094211600 2.668607e-03 9.278325e-03 3 94044087 94044176 90 + 0.174 0.725 3.130
ENSG00000169379 E030 43.0301493 0.0005455447 4.552292e-03 1.468796e-02 3 94049406 94049522 117 + 1.523 1.300 -0.771
ENSG00000169379 E031 35.2803985 0.0005609062 9.898702e-03 2.851442e-02 3 94050824 94050892 69 + 1.440 1.218 -0.776
ENSG00000169379 E032 50.4641075 0.0004972119 3.299232e-02 7.779020e-02 3 94053187 94053300 114 + 1.584 1.442 -0.485
ENSG00000169379 E033 60.8832876 0.0006433346 1.647851e-01 2.814084e-01 3 94053301 94053456 156 + 1.655 1.580 -0.253
ENSG00000169379 E034 209.2735399 0.0018988055 7.906016e-17 3.443944e-15 3 94053457 94055678 2222 + 2.120 2.398 0.928