ENSG00000169249

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307771 ENSG00000169249 HEK293_OSMI2_2hA HEK293_TMG_2hB ZRSR2 protein_coding protein_coding 10.26632 10.35545 11.24534 0.5485168 0.3144883 0.1188261 6.2454070 6.5940408 6.2860297 0.28644076 0.4587200 -0.06890668 0.60776250 0.63790000 0.55800000 -0.07990000 3.157502e-01 1.035332e-05 FALSE  
ENST00000380308 ENSG00000169249 HEK293_OSMI2_2hA HEK293_TMG_2hB ZRSR2 protein_coding protein_coding 10.26632 10.35545 11.24534 0.5485168 0.3144883 0.1188261 1.1899919 1.0154583 1.9482180 0.23155961 0.2665320 0.93327254 0.11499583 0.09643333 0.17476667 0.07833333 1.837017e-01 1.035332e-05 FALSE  
ENST00000468028 ENSG00000169249 HEK293_OSMI2_2hA HEK293_TMG_2hB ZRSR2 protein_coding processed_transcript 10.26632 10.35545 11.24534 0.5485168 0.3144883 0.1188261 0.2850254 0.0000000 0.6550255 0.00000000 0.2562411 6.05533772 0.02682917 0.00000000 0.05723333 0.05723333 1.035332e-05 1.035332e-05    
MSTRG.33926.3 ENSG00000169249 HEK293_OSMI2_2hA HEK293_TMG_2hB ZRSR2 protein_coding   10.26632 10.35545 11.24534 0.5485168 0.3144883 0.1188261 1.5300259 1.7227546 1.6844876 0.09590392 0.3510706 -0.03221834 0.14938333 0.16636667 0.15090000 -0.01546667 8.472131e-01 1.035332e-05 FALSE  
MSTRG.33926.9 ENSG00000169249 HEK293_OSMI2_2hA HEK293_TMG_2hB ZRSR2 protein_coding   10.26632 10.35545 11.24534 0.5485168 0.3144883 0.1188261 0.5829397 0.8797706 0.2914057 0.05950635 0.1722699 -1.56172687 0.05841250 0.08593333 0.02513333 -0.06080000 2.557630e-01 1.035332e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169249 E001 3.2129867 0.0051265225 5.058337e-02 1.101925e-01 X 15790156 15790302 147 + 0.755 0.462 -1.308
ENSG00000169249 E002 2.5916116 0.0664076475 1.541107e-01 2.672484e-01 X 15790303 15790435 133 + 0.671 0.413 -1.216
ENSG00000169249 E003 3.4257233 0.0048026200 5.445157e-01 6.749734e-01 X 15790436 15790470 35 + 0.701 0.619 -0.351
ENSG00000169249 E004 3.3505821 0.0047487295 4.107413e-01 5.543353e-01 X 15790471 15790471 1 + 0.701 0.585 -0.502
ENSG00000169249 E005 13.5246580 0.0017206537 1.251993e-01 2.274279e-01 X 15790472 15790483 12 + 1.224 1.093 -0.470
ENSG00000169249 E006 28.1495739 0.0007630256 7.268246e-02 1.478077e-01 X 15790484 15790511 28 + 1.517 1.409 -0.371
ENSG00000169249 E007 34.6774659 0.0006118569 2.727991e-02 6.655887e-02 X 15790512 15790536 25 + 1.612 1.491 -0.411
ENSG00000169249 E008 1.5188264 0.0100067364 4.017056e-02 9.135447e-02 X 15790865 15790933 69 + 0.566 0.213 -2.087
ENSG00000169249 E009 55.6005600 0.0004254879 1.571750e-02 4.210097e-02 X 15790934 15791013 80 + 1.804 1.701 -0.348
ENSG00000169249 E010 1.9270710 0.0089569528 6.645050e-01 7.723173e-01 X 15796142 15796165 24 + 0.428 0.506 0.397
ENSG00000169249 E011 3.9553049 0.0071124463 6.686941e-02 1.381665e-01 X 15796166 15796250 85 + 0.525 0.803 1.191
ENSG00000169249 E012 40.4667850 0.0005864192 9.096662e-02 1.766672e-01 X 15799872 15799882 11 + 1.662 1.579 -0.283
ENSG00000169249 E013 65.0685609 0.0004075664 5.669715e-03 1.773923e-02 X 15799883 15799953 71 + 1.878 1.769 -0.366
ENSG00000169249 E014 17.2429931 0.0110307803 2.347225e-01 3.680321e-01 X 15801274 15801790 517 + 1.318 1.222 -0.337
ENSG00000169249 E015 60.0615573 0.0004547073 4.483889e-01 5.896771e-01 X 15803688 15803796 109 + 1.797 1.772 -0.087
ENSG00000169249 E016 54.8535806 0.0005094476 7.015329e-01 8.006706e-01 X 15804111 15804197 87 + 1.748 1.738 -0.034
ENSG00000169249 E017 44.5121947 0.0006566285 7.741069e-01 8.543429e-01 X 15808233 15808271 39 + 1.639 1.661 0.075
ENSG00000169249 E018 68.7722016 0.0020210862 1.197993e-01 2.196939e-01 X 15809200 15809318 119 + 1.793 1.870 0.259
ENSG00000169249 E019 91.3589062 0.0154294145 1.072286e-01 2.014352e-01 X 15815677 15815890 214 + 1.901 2.006 0.352
ENSG00000169249 E020 51.1393454 0.0116921485 3.657148e-01 5.100117e-01 X 15818587 15818642 56 + 1.678 1.743 0.220
ENSG00000169249 E021 70.1710608 0.0003936917 1.389781e-03 5.273283e-03 X 15820207 15820316 110 + 1.766 1.906 0.473
ENSG00000169249 E022 54.1260690 0.0004405557 3.662301e-02 8.475282e-02 X 15822731 15822844 114 + 1.675 1.781 0.360
ENSG00000169249 E023 100.2057703 0.0003643731 1.024593e-04 5.334198e-04 X 15822845 15823196 352 + 1.916 2.058 0.476
ENSG00000169249 E024 8.6477242 0.0655580418 5.081216e-01 6.435768e-01 X 15823197 15823201 5 + 0.922 1.037 0.425
ENSG00000169249 E025 6.9830113 0.0874361798 5.217946e-01 6.556647e-01 X 15823202 15823260 59 + 0.846 0.944 0.373
ENSG00000169249 E026 1.8487988 0.0076273284 1.208768e-02 3.374458e-02 X 15824242 15824372 131 + 0.639 0.213 -2.408
ENSG00000169249 E027 0.1451727 0.0439978734 4.593122e-01   X 15824373 15825718 1346 + 0.126 0.000 -9.464
ENSG00000169249 E028 16.4615247 0.0013571883 4.473189e-13 1.161821e-11 X 15827189 15830694 3506 + 1.484 0.845 -2.298