ENSG00000169231

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000469769 ENSG00000169231 HEK293_OSMI2_2hA HEK293_TMG_2hB THBS3 protein_coding retained_intron 4.488561 4.92221 3.889274 0.4737341 0.2734839 -0.3390285 0.7814335 0.8285147 0.3893875 0.09472691 0.02322373 -1.0700468 0.17083333 0.1677333 0.10103333 -0.06670000 0.12203671 0.03531791 TRUE FALSE
ENST00000498500 ENSG00000169231 HEK293_OSMI2_2hA HEK293_TMG_2hB THBS3 protein_coding retained_intron 4.488561 4.92221 3.889274 0.4737341 0.2734839 -0.3390285 0.4200395 0.4038339 0.2318956 0.11742420 0.12102625 -0.7746671 0.08853333 0.0865000 0.05730000 -0.02920000 0.76846321 0.03531791 FALSE FALSE
MSTRG.2305.1 ENSG00000169231 HEK293_OSMI2_2hA HEK293_TMG_2hB THBS3 protein_coding   4.488561 4.92221 3.889274 0.4737341 0.2734839 -0.3390285 0.7137238 0.2254062 2.0483380 0.22540616 0.41516816 3.1282559 0.16114167 0.0541000 0.54450000 0.49040000 0.03531791 0.03531791 FALSE TRUE
MSTRG.2305.2 ENSG00000169231 HEK293_OSMI2_2hA HEK293_TMG_2hB THBS3 protein_coding   4.488561 4.92221 3.889274 0.4737341 0.2734839 -0.3390285 0.9946694 2.1927244 0.3231947 0.62802719 0.32319473 -2.7248515 0.22423333 0.4305000 0.07563333 -0.35486667 0.08505443 0.03531791 FALSE TRUE
MSTRG.2305.6 ENSG00000169231 HEK293_OSMI2_2hA HEK293_TMG_2hB THBS3 protein_coding   4.488561 4.92221 3.889274 0.4737341 0.2734839 -0.3390285 0.4209931 0.5993382 0.2818038 0.05828875 0.14001159 -1.0622447 0.09332917 0.1257667 0.06873333 -0.05703333 0.42745081 0.03531791 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169231 E001 0.1515154 0.0418595409 0.364113186   1 155195588 155195589 2 - 0.140 0.000 -10.840
ENSG00000169231 E002 0.8178402 0.0842018804 0.328929664 0.472415584 1 155195590 155195616 27 - 0.140 0.323 1.532
ENSG00000169231 E003 14.0259449 0.0087115821 0.376512042 0.520824626 1 155195617 155195665 49 - 1.108 1.196 0.316
ENSG00000169231 E004 21.9545248 0.0019544454 0.394081891 0.537972214 1 155195666 155195790 125 - 1.302 1.366 0.223
ENSG00000169231 E005 24.1444899 0.0009006457 0.125402871 0.227718594 1 155195791 155195844 54 - 1.310 1.420 0.380
ENSG00000169231 E006 28.9876286 0.0006814754 0.063388259 0.132338435 1 155195845 155195899 55 - 1.378 1.499 0.420
ENSG00000169231 E007 35.4874556 0.0006446030 0.097387180 0.186486907 1 155195987 155196126 140 - 1.482 1.579 0.333
ENSG00000169231 E008 3.1481625 0.0058192593 0.988422534 0.996814960 1 155196127 155196442 316 - 0.607 0.608 0.003
ENSG00000169231 E009 47.6661695 0.0005092096 0.002676814 0.009302974 1 155197041 155197213 173 - 1.566 1.722 0.529
ENSG00000169231 E010 7.4740351 0.0023065681 0.858808314 0.912909094 1 155197214 155197462 249 - 0.895 0.915 0.076
ENSG00000169231 E011 46.9910762 0.0005134803 0.831697834 0.894534847 1 155197463 155197659 197 - 1.659 1.668 0.032
ENSG00000169231 E012 19.0962894 0.0011005564 0.266614750 0.404842497 1 155197880 155197896 17 - 1.342 1.254 -0.306
ENSG00000169231 E013 19.2852909 0.0082265269 0.922555460 0.955160771 1 155197897 155197928 32 - 1.302 1.292 -0.037
ENSG00000169231 E014 21.0630871 0.0145853870 0.546582965 0.676743369 1 155198042 155198070 29 - 1.364 1.310 -0.189
ENSG00000169231 E015 49.6058758 0.0005719731 0.871460760 0.921318266 1 155198071 155198220 150 - 1.690 1.681 -0.031
ENSG00000169231 E016 0.5944058 0.2217295835 0.802444051 0.874151089 1 155198221 155198261 41 - 0.140 0.196 0.583
ENSG00000169231 E017 0.6245948 0.0269463800 0.143802310 0.253186953 1 155198383 155198408 26 - 0.000 0.264 11.250
ENSG00000169231 E018 47.7358158 0.0005206192 0.370130878 0.514560471 1 155198409 155198602 194 - 1.694 1.647 -0.158
ENSG00000169231 E019 1.2146601 0.0111776337 0.112664825 0.209441885 1 155198603 155198737 135 - 0.140 0.426 2.129
ENSG00000169231 E020 22.7507951 0.0091728453 0.959377167 0.978519154 1 155199804 155199852 49 - 1.349 1.349 0.001
ENSG00000169231 E021 12.5905176 0.0371722737 0.731340174 0.823028133 1 155199853 155199856 4 - 1.121 1.095 -0.091
ENSG00000169231 E022 1.0997650 0.0121989077 0.183510011 0.305608583 1 155199982 155199994 13 - 0.140 0.379 1.868
ENSG00000169231 E023 30.9116976 0.0072015146 0.918794847 0.952709739 1 155199995 155200113 119 - 1.482 1.476 -0.021
ENSG00000169231 E024 12.4116096 0.0017680909 0.594745870 0.716935211 1 155200451 155200455 5 - 1.081 1.131 0.178
ENSG00000169231 E025 36.6245755 0.0006070095 0.750234892 0.836978386 1 155200456 155200610 155 - 1.543 1.560 0.058
ENSG00000169231 E026 1.2199456 0.0110691857 0.458984112 0.599222238 1 155200617 155200896 280 - 0.246 0.378 0.867
ENSG00000169231 E027 19.4824150 0.0011649279 0.365299441 0.509638883 1 155200897 155200898 2 - 1.240 1.311 0.249
ENSG00000169231 E028 33.4887484 0.0006896830 0.851711157 0.908052247 1 155200899 155201004 106 - 1.524 1.511 -0.044
ENSG00000169231 E029 19.6327406 0.0012104188 0.931236712 0.960683954 1 155201094 155201204 111 - 1.294 1.299 0.018
ENSG00000169231 E030 25.5365622 0.0154146818 0.592597147 0.715123095 1 155201417 155201569 153 - 1.442 1.391 -0.174
ENSG00000169231 E031 19.5336784 0.0010315225 0.224879380 0.356287519 1 155201957 155202034 78 - 1.349 1.254 -0.331
ENSG00000169231 E032 2.0241710 0.0072438620 0.594754761 0.716941367 1 155202035 155202047 13 - 0.517 0.426 -0.454
ENSG00000169231 E033 2.0252152 0.0072609533 0.966234996 0.982804686 1 155202048 155202114 67 - 0.463 0.469 0.030
ENSG00000169231 E034 1.4060050 0.0587206961 0.683803584 0.786916394 1 155202115 155202260 146 - 0.402 0.327 -0.443
ENSG00000169231 E035 21.1904684 0.0009522931 0.042969640 0.096489929 1 155202261 155202401 141 - 1.418 1.267 -0.523
ENSG00000169231 E036 17.8458895 0.0010364645 0.107951561 0.202492147 1 155202812 155202960 149 - 1.334 1.204 -0.455
ENSG00000169231 E037 6.6948426 0.0025510425 0.773596396 0.853908817 1 155203086 155203092 7 - 0.851 0.885 0.130
ENSG00000169231 E038 10.8977333 0.0023212033 0.979960876 0.991490505 1 155203093 155203137 45 - 1.067 1.063 -0.015
ENSG00000169231 E039 12.2688286 0.0367265450 0.953469529 0.974865976 1 155203223 155203305 83 - 1.107 1.113 0.020
ENSG00000169231 E040 9.7154482 0.0023903034 0.274205780 0.413337755 1 155203513 155203539 27 - 0.936 1.053 0.433
ENSG00000169231 E041 15.2665820 0.0014507016 0.909739464 0.946630922 1 155204855 155204957 103 - 1.200 1.189 -0.040
ENSG00000169231 E042 26.5153290 0.0018351922 0.362308207 0.506697103 1 155205060 155205316 257 - 1.460 1.397 -0.218
ENSG00000169231 E043 1.3620124 0.0699660567 0.187095407 0.310093904 1 155206193 155206199 7 - 0.517 0.262 -1.465
ENSG00000169231 E044 22.5890241 0.0008658263 0.057306942 0.121998295 1 155206200 155206406 207 - 1.436 1.299 -0.476
ENSG00000169231 E045 2.8263201 0.0899079689 0.256142426 0.393099764 1 155206516 155206554 39 - 0.682 0.474 -0.947
ENSG00000169231 E046 3.6701846 0.0383332907 0.305626358 0.447754242 1 155206555 155206620 66 - 0.746 0.580 -0.706
ENSG00000169231 E047 4.7524461 0.0062182138 0.424231577 0.567203972 1 155206717 155206788 72 - 0.802 0.690 -0.453
ENSG00000169231 E048 3.8151538 0.0070466034 0.766417891 0.848920099 1 155207798 155207981 184 - 0.646 0.689 0.182
ENSG00000169231 E049 12.9427232 0.0039628060 0.080739395 0.160702621 1 155208906 155209051 146 - 1.221 1.053 -0.602