ENSG00000169193

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307471 ENSG00000169193 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC126 protein_coding protein_coding 4.652995 2.637776 7.341122 0.3176383 0.2237318 1.473183 2.1523047 0.60234437 3.358763 0.09169915 0.21927476 2.4598038 0.38064167 0.226766667 0.4592667 0.23250000 1.662487e-03 1.104266e-16 FALSE FALSE
ENST00000409765 ENSG00000169193 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC126 protein_coding protein_coding 4.652995 2.637776 7.341122 0.3176383 0.2237318 1.473183 0.4259240 0.14241261 1.092070 0.05687252 0.19401794 2.8541621 0.06757917 0.050700000 0.1489667 0.09826667 8.019963e-02 1.104266e-16 FALSE FALSE
ENST00000448353 ENSG00000169193 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC126 protein_coding protein_coding 4.652995 2.637776 7.341122 0.3176383 0.2237318 1.473183 0.6691632 0.01988387 1.394886 0.01988387 0.17983145 5.5549420 0.10299167 0.006066667 0.1891333 0.18306667 1.628400e-07 1.104266e-16 FALSE FALSE
ENST00000484553 ENSG00000169193 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC126 protein_coding processed_transcript 4.652995 2.637776 7.341122 0.3176383 0.2237318 1.473183 1.1129335 1.79801601 1.003865 0.10022145 0.08303607 -0.8345413 0.40332917 0.691533333 0.1368333 -0.55470000 1.104266e-16 1.104266e-16 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169193 E001 5.7968848 0.0039542933 4.654199e-01 6.051415e-01 7 23597382 23597415 34 + 0.734 0.848 0.451
ENSG00000169193 E002 9.2237300 0.0176412526 4.178424e-01 5.611612e-01 7 23597416 23597441 26 + 0.909 1.017 0.406
ENSG00000169193 E003 20.3828500 0.0265763347 3.919745e-02 8.954529e-02 7 23597442 23597514 73 + 1.195 1.413 0.761
ENSG00000169193 E004 29.1109234 0.0010520590 6.351976e-03 1.953765e-02 7 23597515 23597605 91 + 1.348 1.547 0.683
ENSG00000169193 E005 0.2924217 0.0272273129 1.000000e+00   7 23597723 23597837 115 + 0.119 0.001 -8.092
ENSG00000169193 E006 1.2523141 0.0113775239 2.414181e-01 3.758460e-01 7 23597838 23597966 129 + 0.253 0.479 1.350
ENSG00000169193 E007 11.8047575 0.0016359900 7.082857e-02 1.447243e-01 7 23597967 23597971 5 + 0.979 1.179 0.725
ENSG00000169193 E008 23.8469210 0.0008504157 4.400599e-03 1.426631e-02 7 23597972 23598051 80 + 1.260 1.484 0.778
ENSG00000169193 E009 0.1451727 0.0443724943 1.000000e+00   7 23598161 23598222 62 + 0.064 0.001 -7.040
ENSG00000169193 E010 0.0000000       7 23598292 23598518 227 +      
ENSG00000169193 E011 13.0617229 0.0015167634 1.780840e-22 1.499444e-20 7 23601871 23602220 350 + 0.680 1.578 3.282
ENSG00000169193 E012 5.1797812 0.0033130995 1.943528e-02 5.027796e-02 7 23604086 23604141 56 + 0.793 0.369 -1.957
ENSG00000169193 E013 4.6490616 0.0036480569 4.003874e-02 9.110718e-02 7 23604142 23604147 6 + 0.746 0.370 -1.770
ENSG00000169193 E014 7.4367526 0.0064561414 1.460054e-03 5.507384e-03 7 23604148 23604279 132 + 0.933 0.370 -2.497
ENSG00000169193 E015 62.6012796 0.0006688435 3.609293e-10 5.796623e-09 7 23611171 23611553 383 + 1.785 1.423 -1.235
ENSG00000169193 E016 130.1044752 0.0005271737 3.503754e-04 1.581516e-03 7 23642931 23644708 1778 + 2.063 1.961 -0.341