ENSG00000169093

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000381317 ENSG00000169093 HEK293_OSMI2_2hA HEK293_TMG_2hB ASMTL protein_coding protein_coding 32.70747 60.56289 18.87095 1.731746 0.599145 -1.681741 28.155870 53.64168 14.827215 1.9366076 0.56410875 -1.8544031 0.8433792 0.88536667 0.7854667 -0.09990000 2.847886e-05 2.847886e-05 FALSE  
MSTRG.33854.6 ENSG00000169093 HEK293_OSMI2_2hA HEK293_TMG_2hB ASMTL protein_coding   32.70747 60.56289 18.87095 1.731746 0.599145 -1.681741 2.298126 3.27754 2.125622 0.4064314 0.06482535 -0.6223525 0.0796625 0.05453333 0.1130000 0.05846667 4.851380e-03 2.847886e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169093 E001 0.000000       X 1402716 1402730 15 -      
ENSG00000169093 E002 0.000000       X 1402889 1402979 91 -      
ENSG00000169093 E003 1.954139 0.0071092097 1.077857e-01 2.022672e-01 X 1402980 1403138 159 - 0.617 0.338 -1.413
ENSG00000169093 E004 5.630448 0.0029233051 3.877471e-01 5.318923e-01 X 1403139 1403140 2 - 0.823 0.703 -0.483
ENSG00000169093 E005 337.424496 0.0042054046 6.169303e-06 4.303542e-05 X 1403141 1403489 349 - 2.255 2.447 0.639
ENSG00000169093 E006 291.896503 0.0026969818 1.622720e-06 1.287513e-05 X 1412732 1412841 110 - 2.195 2.384 0.629
ENSG00000169093 E007 141.595023 0.0071078982 9.872488e-02 1.885377e-01 X 1412842 1412854 13 - 1.958 2.060 0.344
ENSG00000169093 E008 286.898151 0.0034652407 2.532443e-04 1.188770e-03 X 1417973 1418116 144 - 2.217 2.371 0.513
ENSG00000169093 E009 304.289522 0.0009747079 3.392249e-03 1.141558e-02 X 1418982 1419114 133 - 2.290 2.386 0.318
ENSG00000169093 E010 422.955437 0.0001793074 1.907704e-01 3.147146e-01 X 1421658 1421842 185 - 2.483 2.518 0.120
ENSG00000169093 E011 44.361514 0.0172108452 1.478621e-02 4.001155e-02 X 1422983 1423507 525 - 1.704 1.509 -0.665
ENSG00000169093 E012 422.405766 0.0001321627 8.712551e-01 9.212053e-01 X 1425525 1425687 163 - 2.504 2.514 0.036
ENSG00000169093 E013 1.580234 0.0090105941 3.924003e-01 5.363492e-01 X 1427727 1427733 7 - 0.460 0.304 -0.896
ENSG00000169093 E014 665.314910 0.0002359083 5.114743e-02 1.112095e-01 X 1427734 1428121 388 - 2.729 2.703 -0.086
ENSG00000169093 E015 4.574781 0.0036578745 7.750176e-04 3.169313e-03 X 1431902 1432268 367 - 0.991 0.526 -1.898
ENSG00000169093 E016 377.543864 0.0028387129 6.332171e-03 1.948654e-02 X 1432269 1432377 109 - 2.526 2.448 -0.261
ENSG00000169093 E017 275.615669 0.0002235628 2.851525e-05 1.705163e-04 X 1435022 1435083 62 - 2.406 2.306 -0.333
ENSG00000169093 E018 1.502915 0.0149259232 5.399868e-01 6.711864e-01 X 1435084 1435391 308 - 0.212 0.339 0.914
ENSG00000169093 E019 301.784304 0.0011475008 1.534871e-04 7.625328e-04 X 1435694 1435758 65 - 2.445 2.346 -0.331
ENSG00000169093 E020 261.120841 0.0005674005 1.836569e-03 6.716583e-03 X 1439097 1439144 48 - 2.367 2.287 -0.266
ENSG00000169093 E021 27.309026 0.0010929975 1.336282e-01 2.391930e-01 X 1441592 1442185 594 - 1.427 1.317 -0.384
ENSG00000169093 E022 371.280503 0.0006368114 1.161989e-01 2.145568e-01 X 1442186 1442317 132 - 2.481 2.449 -0.104
ENSG00000169093 E023 227.090925 0.0028502067 4.249910e-01 5.679328e-01 X 1452748 1452906 159 - 2.260 2.238 -0.073
ENSG00000169093 E024 5.184433 0.0032200970 3.267963e-01 4.702451e-01 X 1452907 1452939 33 - 0.546 0.717 0.747
ENSG00000169093 E025 2.132795 0.1336966608 8.628551e-01 9.155720e-01 X 1453618 1453762 145 - 0.353 0.411 0.330