ENSG00000169087

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306103 ENSG00000169087 HEK293_OSMI2_2hA HEK293_TMG_2hB HSPBAP1 protein_coding protein_coding 4.717671 3.54735 4.79783 0.4712301 0.1255545 0.434583 3.0114198 2.1397843 3.5000277 0.35669890 0.07507490 0.7072905 0.61860833 0.60343333 0.73116667 0.12773333 0.421434429 0.006554452 FALSE TRUE
ENST00000465044 ENSG00000169087 HEK293_OSMI2_2hA HEK293_TMG_2hB HSPBAP1 protein_coding processed_transcript 4.717671 3.54735 4.79783 0.4712301 0.1255545 0.434583 0.8256369 0.9265145 0.5898959 0.14837708 0.01827277 -0.6425890 0.19037083 0.26173333 0.12330000 -0.13843333 0.006554452 0.006554452 FALSE TRUE
ENST00000467643 ENSG00000169087 HEK293_OSMI2_2hA HEK293_TMG_2hB HSPBAP1 protein_coding processed_transcript 4.717671 3.54735 4.79783 0.4712301 0.1255545 0.434583 0.2447941 0.1099301 0.3072484 0.06458915 0.16769807 1.4034186 0.05249583 0.02813333 0.06236667 0.03423333 0.868135468 0.006554452 FALSE TRUE
ENST00000471534 ENSG00000169087 HEK293_OSMI2_2hA HEK293_TMG_2hB HSPBAP1 protein_coding processed_transcript 4.717671 3.54735 4.79783 0.4712301 0.1255545 0.434583 0.4208098 0.2442554 0.1347457 0.04092839 0.01986992 -0.8127584 0.09483750 0.07176667 0.02810000 -0.04366667 0.206773531 0.006554452 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169087 E001 1.1039192 0.0132718979 6.498364e-01 7.609736e-01 3 122739999 122740002 4 - 0.289 0.370 0.511
ENSG00000169087 E002 71.5450615 0.0042804093 8.471977e-01 9.050870e-01 3 122740003 122740875 873 - 1.860 1.870 0.033
ENSG00000169087 E003 24.7737104 0.0009227283 8.165857e-01 8.839630e-01 3 122741003 122741113 111 - 1.423 1.407 -0.054
ENSG00000169087 E004 4.4513027 0.0039452381 1.288961e-01 2.326237e-01 3 122741114 122741776 663 - 0.618 0.827 0.862
ENSG00000169087 E005 18.1955009 0.0012031437 1.547831e-01 2.681247e-01 3 122752591 122752674 84 - 1.344 1.234 -0.385
ENSG00000169087 E006 48.9812373 0.0007001969 4.009958e-11 7.558199e-10 3 122752861 122755071 2211 - 1.511 1.830 1.080
ENSG00000169087 E007 19.3550922 0.0012099171 4.170221e-01 5.604099e-01 3 122755260 122755323 64 - 1.344 1.283 -0.215
ENSG00000169087 E008 26.6129966 0.0007457007 5.078364e-01 6.432613e-01 3 122755324 122755431 108 - 1.467 1.424 -0.147
ENSG00000169087 E009 1.5081155 0.0092218082 5.976424e-01 7.193822e-01 3 122758772 122758853 82 - 0.461 0.370 -0.490
ENSG00000169087 E010 0.2903454 0.3576646762 3.199029e-01   3 122759220 122759223 4 - 0.211 0.000 -9.408
ENSG00000169087 E011 27.5388653 0.0139781162 2.001423e-01 3.264305e-01 3 122759224 122759360 137 - 1.515 1.405 -0.381
ENSG00000169087 E012 2.7043312 0.0193859147 8.587757e-02 1.687860e-01 3 122761534 122761972 439 - 0.707 0.427 -1.288
ENSG00000169087 E013 33.5704804 0.0007336024 1.209247e-01 2.212707e-01 3 122768701 122768882 182 - 1.585 1.495 -0.306
ENSG00000169087 E014 32.6767072 0.0006974570 5.083781e-02 1.106676e-01 3 122777721 122777906 186 - 1.585 1.471 -0.389
ENSG00000169087 E015 0.4751703 0.0222081045 5.286667e-01 6.615737e-01 3 122786409 122786490 82 - 0.119 0.223 1.096
ENSG00000169087 E016 22.5039691 0.0010194256 4.836615e-01 6.216972e-01 3 122793617 122793831 215 - 1.396 1.346 -0.173