ENSG00000169071

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375708 ENSG00000169071 HEK293_OSMI2_2hA HEK293_TMG_2hB ROR2 protein_coding protein_coding 1.579172 2.401291 1.557724 0.3105455 0.09013065 -0.6211347 1.24534452 1.79827487 1.1935310 0.18768137 0.03874578 -0.5873407 0.80942917 0.75450000 0.77030000 0.01580000 9.202719e-01 7.172058e-05 FALSE TRUE
ENST00000476440 ENSG00000169071 HEK293_OSMI2_2hA HEK293_TMG_2hB ROR2 protein_coding processed_transcript 1.579172 2.401291 1.557724 0.3105455 0.09013065 -0.6211347 0.11453284 0.08030826 0.1214828 0.04403132 0.01329493 0.5419443 0.06127500 0.03666667 0.07893333 0.04226667 4.786402e-01 7.172058e-05   FALSE
ENST00000493846 ENSG00000169071 HEK293_OSMI2_2hA HEK293_TMG_2hB ROR2 protein_coding processed_transcript 1.579172 2.401291 1.557724 0.3105455 0.09013065 -0.6211347 0.09210622 0.41725788 0.0000000 0.15224939 0.00000000 -5.4170352 0.03845833 0.16366667 0.00000000 -0.16366667 7.172058e-05 7.172058e-05 FALSE FALSE
ENST00000495386 ENSG00000169071 HEK293_OSMI2_2hA HEK293_TMG_2hB ROR2 protein_coding processed_transcript 1.579172 2.401291 1.557724 0.3105455 0.09013065 -0.6211347 0.03635165 0.00000000 0.1387064 0.00000000 0.07860092 3.8943949 0.02261250 0.00000000 0.08400000 0.08400000 1.133150e-01 7.172058e-05 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169071 E001 0.2903454 0.334637145 0.175787663   9 91563091 91563329 239 - 0.249 0.000 -11.437
ENSG00000169071 E002 0.9211837 0.013348156 0.192803868 0.317287303 9 91694320 91694411 92 - 0.407 0.189 -1.505
ENSG00000169071 E003 1.2511813 0.010509457 0.571941413 0.698143600 9 91717307 91717396 90 - 0.407 0.321 -0.505
ENSG00000169071 E004 0.3729606 0.029818820 0.767889808 0.850021740 9 91722526 91722580 55 - 0.142 0.105 -0.501
ENSG00000169071 E005 0.0000000       9 91722601 91722601 1 -      
ENSG00000169071 E006 85.1472834 0.017989703 0.001332592 0.005084806 9 91722602 91724153 1552 - 1.766 1.986 0.742
ENSG00000169071 E007 43.7497798 0.002382564 0.275348187 0.414644112 9 91724154 91725107 954 - 1.651 1.618 -0.112
ENSG00000169071 E008 14.5827800 0.022227923 0.332146296 0.475775158 9 91726541 91726743 203 - 1.218 1.145 -0.260
ENSG00000169071 E009 16.4339320 0.001509792 0.044687249 0.099628609 9 91730910 91731155 246 - 1.088 1.286 0.705
ENSG00000169071 E010 20.7352177 0.001071562 0.061665420 0.129428311 9 91733122 91733436 315 - 1.207 1.375 0.586
ENSG00000169071 E011 17.1591671 0.002870293 0.837776956 0.898589851 9 91737391 91737518 128 - 1.207 1.248 0.145
ENSG00000169071 E012 0.4502799 0.035611186 0.039033184 0.089256465 9 91755940 91756070 131 - 0.335 0.000 -14.832
ENSG00000169071 E013 11.5026981 0.001522010 0.186764021 0.309666575 9 91756071 91756101 31 - 1.140 1.035 -0.378
ENSG00000169071 E014 12.1993147 0.001624612 0.106529548 0.200440009 9 91757272 91757333 62 - 1.175 1.046 -0.463
ENSG00000169071 E015 14.2939435 0.020288657 0.096942852 0.185816368 9 91757334 91757428 95 - 1.256 1.100 -0.556
ENSG00000169071 E016 8.0806510 0.005129561 0.130674843 0.235096575 9 91757429 91757435 7 - 1.029 0.879 -0.561
ENSG00000169071 E017 13.7927489 0.004017982 0.058558826 0.124162486 9 91757436 91757559 124 - 1.237 1.087 -0.536
ENSG00000169071 E018 9.5263238 0.001944762 0.039145038 0.089452855 9 91775741 91775818 78 - 1.114 0.923 -0.703
ENSG00000169071 E019 1.2168251 0.010950730 0.879772472 0.926846966 9 91883258 91883383 126 - 0.335 0.321 -0.087
ENSG00000169071 E020 0.2214452 0.037675830 0.699823971   9 91886668 91886770 103 - 0.000 0.105 11.744
ENSG00000169071 E021 0.0000000       9 91886864 91887199 336 -      
ENSG00000169071 E022 0.0000000       9 91923653 91923667 15 -      
ENSG00000169071 E023 1.5770116 0.009040007 0.261543242 0.399195806 9 91923668 91923764 97 - 0.249 0.464 1.304
ENSG00000169071 E024 3.0465176 0.005437127 0.922722977 0.955271814 9 91923765 91923928 164 - 0.570 0.603 0.149
ENSG00000169071 E025 2.6131765 0.006007257 0.282972882 0.423039122 9 91948607 91948880 274 - 0.407 0.603 0.956
ENSG00000169071 E026 9.2892385 0.027530873 0.019796242 0.051055580 9 91949867 91950228 362 - 1.152 0.878 -1.008