ENSG00000169062

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000351487 ENSG00000169062 HEK293_OSMI2_2hA HEK293_TMG_2hB UPF3A protein_coding protein_coding 13.18967 10.95929 15.84295 0.6312582 0.2005327 0.5312812 2.0494863 2.0461037 1.240795 0.52303961 0.39464401 -0.7170682 0.15807083 0.187300000 0.07896667 -0.10833333 1.631877e-01 9.431384e-11 FALSE TRUE
ENST00000375299 ENSG00000169062 HEK293_OSMI2_2hA HEK293_TMG_2hB UPF3A protein_coding protein_coding 13.18967 10.95929 15.84295 0.6312582 0.2005327 0.5312812 1.6284422 1.6181270 2.342905 0.23509691 0.35992955 0.5312299 0.12352083 0.147900000 0.14740000 -0.00050000 1.000000e+00 9.431384e-11 FALSE TRUE
ENST00000475218 ENSG00000169062 HEK293_OSMI2_2hA HEK293_TMG_2hB UPF3A protein_coding processed_transcript 13.18967 10.95929 15.84295 0.6312582 0.2005327 0.5312812 1.3057769 0.6816535 2.329503 0.68165352 0.74337954 1.7580809 0.09865000 0.057733333 0.14820000 0.09046667 2.119748e-01 9.431384e-11 FALSE TRUE
ENST00000492270 ENSG00000169062 HEK293_OSMI2_2hA HEK293_TMG_2hB UPF3A protein_coding protein_coding 13.18967 10.95929 15.84295 0.6312582 0.2005327 0.5312812 2.2382656 3.3158374 1.648291 0.15221161 0.19550079 -1.0040202 0.18030833 0.303033333 0.10386667 -0.19916667 9.431384e-11 9.431384e-11 FALSE TRUE
ENST00000493727 ENSG00000169062 HEK293_OSMI2_2hA HEK293_TMG_2hB UPF3A protein_coding processed_transcript 13.18967 10.95929 15.84295 0.6312582 0.2005327 0.5312812 0.3647002 0.1307859 1.021914 0.13078589 0.13003635 2.8737487 0.02530833 0.011066667 0.06440000 0.05333333 9.617243e-02 9.431384e-11 FALSE FALSE
ENST00000618700 ENSG00000169062 HEK293_OSMI2_2hA HEK293_TMG_2hB UPF3A protein_coding retained_intron 13.18967 10.95929 15.84295 0.6312582 0.2005327 0.5312812 0.7361213 0.1001696 1.091901 0.01008988 0.12471487 3.3221963 0.05245417 0.009333333 0.06880000 0.05946667 5.950169e-07 9.431384e-11 FALSE TRUE
ENST00000619079 ENSG00000169062 HEK293_OSMI2_2hA HEK293_TMG_2hB UPF3A protein_coding retained_intron 13.18967 10.95929 15.84295 0.6312582 0.2005327 0.5312812 1.1441204 0.5961043 1.372481 0.16531950 0.06433846 1.1896216 0.08484583 0.053800000 0.08660000 0.03280000 3.028633e-01 9.431384e-11 FALSE FALSE
MSTRG.9117.12 ENSG00000169062 HEK293_OSMI2_2hA HEK293_TMG_2hB UPF3A protein_coding   13.18967 10.95929 15.84295 0.6312582 0.2005327 0.5312812 1.1833711 0.7233539 1.773342 0.36160535 0.32771177 1.2820016 0.08724167 0.067133333 0.11140000 0.04426667 5.960012e-01 9.431384e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169062 E001 0.5848540 0.1190251277 5.243934e-02 1.135006e-01 13 114281601 114281602 2 + 0.000 0.336 11.393
ENSG00000169062 E002 8.2309307 0.0040653641 2.619341e-02 6.434136e-02 13 114281603 114281627 25 + 0.830 1.086 0.957
ENSG00000169062 E003 9.6743107 0.0021028123 3.758493e-03 1.246386e-02 13 114281628 114281634 7 + 0.864 1.173 1.137
ENSG00000169062 E004 9.8613005 0.0023048729 5.791544e-03 1.806525e-02 13 114281635 114281636 2 + 0.880 1.173 1.076
ENSG00000169062 E005 11.4487072 0.0152388408 2.692159e-03 9.350301e-03 13 114281637 114281644 8 + 0.910 1.252 1.243
ENSG00000169062 E006 26.4331489 0.0008924375 2.453217e-06 1.871973e-05 13 114281645 114281719 75 + 1.262 1.584 1.114
ENSG00000169062 E007 41.9455879 0.0005917143 2.854085e-09 3.889353e-08 13 114281720 114281846 127 + 1.450 1.776 1.110
ENSG00000169062 E008 0.8751888 0.1056799060 3.497001e-02 8.159828e-02 13 114281925 114281952 28 + 0.422 0.000 -11.680
ENSG00000169062 E009 4.9956296 0.0151153276 2.720785e-02 6.641379e-02 13 114281953 114282020 68 + 0.895 0.569 -1.341
ENSG00000169062 E010 45.5142199 0.0050529181 3.600049e-02 8.358478e-02 13 114282021 114282127 107 + 1.599 1.727 0.435
ENSG00000169062 E011 11.3834454 0.0027050806 4.144486e-03 1.354753e-02 13 114282128 114282270 143 + 0.925 1.216 1.060
ENSG00000169062 E012 8.3460254 0.0366100522 1.157802e-01 2.139199e-01 13 114282405 114282652 248 + 1.068 0.851 -0.811
ENSG00000169062 E013 49.5088554 0.0036536216 9.403853e-02 1.814390e-01 13 114282837 114282943 107 + 1.741 1.650 -0.308
ENSG00000169062 E014 14.3585630 0.0100011080 2.048317e-08 2.383730e-07 13 114282944 114283729 786 + 1.376 0.750 -2.299
ENSG00000169062 E015 21.1787313 0.0009271586 1.533906e-10 2.622925e-09 13 114285077 114285974 898 + 1.516 0.994 -1.843
ENSG00000169062 E016 9.6640982 0.0066016558 5.650764e-06 3.974015e-05 13 114285975 114286258 284 + 1.199 0.651 -2.093
ENSG00000169062 E017 6.2472689 0.0038457318 6.841862e-06 4.723136e-05 13 114286259 114286301 43 + 1.047 0.406 -2.717
ENSG00000169062 E018 33.7189326 0.0010152653 1.035767e-02 2.964450e-02 13 114286302 114286373 72 + 1.599 1.448 -0.518
ENSG00000169062 E019 21.8796998 0.0013324068 2.014940e-03 7.272742e-03 13 114286374 114286384 11 + 1.446 1.216 -0.800
ENSG00000169062 E020 21.1974899 0.0135966205 6.030093e-02 1.271250e-01 13 114286385 114286400 16 + 1.414 1.238 -0.614
ENSG00000169062 E021 3.3237066 0.0046235810 6.778973e-04 2.818143e-03 13 114286401 114286518 118 + 0.812 0.248 -2.830
ENSG00000169062 E022 46.6797343 0.0005731163 8.485585e-01 9.059735e-01 13 114286519 114286629 111 + 1.678 1.675 -0.011
ENSG00000169062 E023 29.2996786 0.0335343100 2.886817e-01 4.292972e-01 13 114286630 114287312 683 + 1.414 1.561 0.504
ENSG00000169062 E024 19.2713036 0.0036365081 1.162655e-04 5.967851e-04 13 114287313 114287617 305 + 1.126 1.447 1.129
ENSG00000169062 E025 20.5375788 0.0009521604 2.327162e-01 3.656732e-01 13 114291489 114291544 56 + 1.366 1.282 -0.293
ENSG00000169062 E026 0.8168978 0.0143804108 3.052402e-01 4.472888e-01 13 114291605 114291633 29 + 0.322 0.142 -1.507
ENSG00000169062 E027 42.3163335 0.0006132109 2.442270e-01 3.791782e-01 13 114291634 114291792 159 + 1.658 1.602 -0.190
ENSG00000169062 E028 53.2568716 0.0006410119 7.636048e-01 8.468768e-01 13 114298840 114299000 161 + 1.741 1.734 -0.023
ENSG00000169062 E029 68.7288725 0.0004576433 1.583594e-01 2.729398e-01 13 114301731 114301867 137 + 1.869 1.818 -0.172
ENSG00000169062 E030 60.8756001 0.0004612560 1.786330e-01 2.994398e-01 13 114301868 114302025 158 + 1.816 1.764 -0.176
ENSG00000169062 E031 144.5127114 0.0058227138 9.187970e-02 1.780426e-01 13 114304789 114305817 1029 + 2.124 2.205 0.270