ENSG00000168924

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302787 ENSG00000168924 HEK293_OSMI2_2hA HEK293_TMG_2hB LETM1 protein_coding protein_coding 60.47447 79.23419 46.584 4.205987 0.5312969 -0.7661611 44.663101 66.294941 31.730054 2.6938105 0.08874262 -1.06281181 0.72271667 0.83786667 0.68126667 -0.15660000 4.618555e-08 1.0362e-08 FALSE TRUE
ENST00000505551 ENSG00000168924 HEK293_OSMI2_2hA HEK293_TMG_2hB LETM1 protein_coding retained_intron 60.47447 79.23419 46.584 4.205987 0.5312969 -0.7661611 3.100092 2.767466 2.950318 0.4603407 0.06315548 0.09198296 0.05429167 0.03466667 0.06333333 0.02866667 5.086675e-03 1.0362e-08 FALSE TRUE
ENST00000510940 ENSG00000168924 HEK293_OSMI2_2hA HEK293_TMG_2hB LETM1 protein_coding retained_intron 60.47447 79.23419 46.584 4.205987 0.5312969 -0.7661611 5.730945 4.281830 5.918169 0.0781809 0.43827185 0.46599373 0.10063750 0.05426667 0.12700000 0.07273333 1.036200e-08 1.0362e-08   FALSE
ENST00000511977 ENSG00000168924 HEK293_OSMI2_2hA HEK293_TMG_2hB LETM1 protein_coding retained_intron 60.47447 79.23419 46.584 4.205987 0.5312969 -0.7661611 5.662824 4.530326 5.113432 1.0093885 0.51495010 0.17431461 0.09975000 0.05640000 0.10963333 0.05323333 3.247438e-02 1.0362e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168924 E001 2599.5934440 0.0004913230 1.111660e-08 1.358801e-07 4 1811479 1813965 2487 - 3.311 3.378 0.220
ENSG00000168924 E002 386.6427270 0.0003527055 2.424041e-03 8.534396e-03 4 1813966 1814069 104 - 2.579 2.513 -0.220
ENSG00000168924 E003 297.9083026 0.0002034651 1.631608e-01 2.792790e-01 4 1814070 1814170 101 - 2.443 2.409 -0.115
ENSG00000168924 E004 1238.7748652 0.0012222915 6.730177e-01 7.788092e-01 4 1814171 1814573 403 - 3.034 3.042 0.027
ENSG00000168924 E005 1059.0555754 0.0008743819 3.959300e-01 5.397212e-01 4 1815664 1815802 139 - 2.961 2.975 0.049
ENSG00000168924 E006 1141.9609733 0.0001965882 1.074677e-02 3.056053e-02 4 1816727 1816914 188 - 2.979 3.010 0.104
ENSG00000168924 E007 568.9904033 0.0001622909 1.380547e-01 2.453706e-01 4 1819338 1819371 34 - 2.682 2.705 0.078
ENSG00000168924 E008 783.1337985 0.0001772112 4.312023e-01 5.737744e-01 4 1819372 1819472 101 - 2.831 2.840 0.033
ENSG00000168924 E009 740.6468483 0.0003117721 1.887280e-02 4.905529e-02 4 1822181 1822309 129 - 2.786 2.823 0.123
ENSG00000168924 E010 288.7673084 0.0002169065 3.125311e-01 4.550644e-01 4 1822310 1822312 3 - 2.389 2.411 0.073
ENSG00000168924 E011 48.1591938 0.0004573073 1.880437e-14 5.945313e-13 4 1822313 1822642 330 - 1.887 1.494 -1.333
ENSG00000168924 E012 29.8668663 0.0010145198 1.038643e-09 1.535689e-08 4 1822774 1822987 214 - 1.687 1.291 -1.360
ENSG00000168924 E013 759.1678795 0.0001585945 2.450889e-03 8.616591e-03 4 1822988 1823131 144 - 2.791 2.835 0.146
ENSG00000168924 E014 583.8785119 0.0001202109 3.877787e-01 5.319274e-01 4 1823644 1823775 132 - 2.701 2.714 0.040
ENSG00000168924 E015 457.6223301 0.0001566213 3.524377e-01 4.966938e-01 4 1825564 1825683 120 - 2.595 2.611 0.051
ENSG00000168924 E016 644.9968728 0.0018377431 7.942917e-01 8.685709e-01 4 1832744 1832947 204 - 2.761 2.754 -0.023
ENSG00000168924 E017 93.0842059 0.0061404375 3.762418e-08 4.156872e-07 4 1833074 1834099 1026 - 2.108 1.816 -0.979
ENSG00000168924 E018 25.1848497 0.0126456275 1.135987e-05 7.452880e-05 4 1834100 1834205 106 - 1.605 1.226 -1.313
ENSG00000168924 E019 76.0739775 0.0019172785 2.132778e-13 5.785344e-12 4 1834206 1834844 639 - 2.047 1.710 -1.137
ENSG00000168924 E020 552.1089265 0.0013952107 1.975202e-01 3.231093e-01 4 1834845 1834982 138 - 2.711 2.679 -0.106
ENSG00000168924 E021 523.9014322 0.0004906813 5.289746e-02 1.143067e-01 4 1836429 1836572 144 - 2.692 2.653 -0.132
ENSG00000168924 E022 0.1817044 0.0393341676 1.000000e+00   4 1839298 1839342 45 - 0.000 0.085 8.050
ENSG00000168924 E023 867.0685541 0.0012972784 1.187854e-03 4.600256e-03 4 1841347 1841797 451 - 2.933 2.864 -0.227
ENSG00000168924 E024 0.1482932 0.0413995998 1.000000e+00   4 1843006 1843211 206 - 0.000 0.085 8.025
ENSG00000168924 E025 2.4586569 0.1189041440 1.846678e-01 3.070563e-01 4 1846474 1846629 156 - 0.692 0.401 -1.368
ENSG00000168924 E026 207.4028672 0.0057807466 1.255502e-04 6.391612e-04 4 1849149 1849209 61 - 2.383 2.210 -0.580
ENSG00000168924 E027 181.6658315 0.0229718376 6.101916e-04 2.570294e-03 4 1855869 1856172 304 - 2.381 2.121 -0.871
ENSG00000168924 E028 1.1394198 0.0965063962 5.292454e-01 6.620530e-01 4 1857027 1857037 11 - 0.393 0.270 -0.775
ENSG00000168924 E029 2.4754805 0.0601787841 4.040143e-01 5.477410e-01 4 1857038 1858508 1471 - 0.596 0.439 -0.752