ENSG00000168916

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306315 ENSG00000168916 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF608 protein_coding protein_coding 0.9689062 0.8534116 1.000707 0.1781137 0.09840326 0.2272438 0.05823825 0.02648133 0.00000000 0.02648133 0.00000000 -1.8671582 0.07493750 0.03250000 0.00000000 -0.0325000000 0.6950172519 0.0002515983 FALSE TRUE
ENST00000503896 ENSG00000168916 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF608 protein_coding processed_transcript 0.9689062 0.8534116 1.000707 0.1781137 0.09840326 0.2272438 0.03993451 0.00000000 0.09168691 0.00000000 0.09168691 3.3460620 0.03298333 0.00000000 0.08030000 0.0803000000 0.8197534701 0.0002515983 FALSE TRUE
ENST00000504926 ENSG00000168916 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF608 protein_coding protein_coding 0.9689062 0.8534116 1.000707 0.1781137 0.09840326 0.2272438 0.26505807 0.14987083 0.20441556 0.02340027 0.13476055 0.4235029 0.24810833 0.18240000 0.18303333 0.0006333333 0.8999885153 0.0002515983 FALSE TRUE
ENST00000509799 ENSG00000168916 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF608 protein_coding protein_coding 0.9689062 0.8534116 1.000707 0.1781137 0.09840326 0.2272438 0.06616679 0.01361936 0.08608165 0.01361936 0.04305253 2.0242912 0.06121250 0.01153333 0.09096667 0.0794333333 0.5294820765 0.0002515983 FALSE TRUE
ENST00000512940 ENSG00000168916 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF608 protein_coding processed_transcript 0.9689062 0.8534116 1.000707 0.1781137 0.09840326 0.2272438 0.02354420 0.00000000 0.05831714 0.00000000 0.05831714 2.7722477 0.02093750 0.00000000 0.05560000 0.0556000000 0.8145431314 0.0002515983 FALSE FALSE
ENST00000513985 ENSG00000168916 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF608 protein_coding processed_transcript 0.9689062 0.8534116 1.000707 0.1781137 0.09840326 0.2272438 0.15533219 0.39533753 0.03181547 0.11759465 0.03181547 -3.2770149 0.17319583 0.45580000 0.03033333 -0.4254666667 0.0002515983 0.0002515983 FALSE TRUE
ENST00000513986 ENSG00000168916 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF608 protein_coding protein_coding 0.9689062 0.8534116 1.000707 0.1781137 0.09840326 0.2272438 0.35763902 0.25348518 0.52838988 0.04887399 0.12492805 1.0309295 0.38414167 0.29980000 0.55980000 0.2600000000 0.4021850891 0.0002515983 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168916 E001 0.0000000       5 124636913 124636914 2 -      
ENSG00000168916 E002 0.0000000       5 124636915 124636915 1 -      
ENSG00000168916 E003 0.0000000       5 124636916 124636916 1 -      
ENSG00000168916 E004 10.5977820 0.010028297 4.691344e-05 0.0002661439 5 124636917 124637277 361 - 0.794 1.241 1.653
ENSG00000168916 E005 19.5300024 0.005909220 2.439023e-04 0.0011496744 5 124637278 124637906 629 - 1.152 1.442 1.016
ENSG00000168916 E006 0.8909922 0.063774591 1.431628e-01 0.2523236478 5 124638782 124638823 42 - 0.116 0.377 2.169
ENSG00000168916 E007 8.2108138 0.002430975 5.757312e-01 0.7012604560 5 124639133 124639214 82 - 0.938 0.998 0.224
ENSG00000168916 E008 8.6387426 0.001989948 6.686379e-01 0.7755933246 5 124641252 124641405 154 - 0.968 1.013 0.167
ENSG00000168916 E009 6.3483897 0.003038917 7.893400e-01 0.8651571920 5 124643511 124643683 173 - 0.890 0.858 -0.122
ENSG00000168916 E010 14.8230950 0.029877275 4.157040e-01 0.5590694718 5 124644244 124644661 418 - 1.162 1.240 0.278
ENSG00000168916 E011 30.7484900 0.016045503 3.890925e-01 0.5331973545 5 124646679 124648236 1558 - 1.541 1.472 -0.236
ENSG00000168916 E012 12.9107145 0.001512007 8.112751e-02 0.1613039627 5 124648237 124649133 897 - 1.222 1.068 -0.551
ENSG00000168916 E013 3.6768956 0.097068328 2.817143e-01 0.4216367335 5 124649610 124649697 88 - 0.773 0.535 -1.022
ENSG00000168916 E014 0.0000000       5 124666271 124666427 157 -      
ENSG00000168916 E015 6.2275092 0.046643320 2.448983e-02 0.0608318741 5 124701014 124701269 256 - 1.010 0.648 -1.422
ENSG00000168916 E016 4.9820884 0.004228915 6.893685e-02 0.1416088863 5 124744084 124744412 329 - 0.890 0.648 -0.970
ENSG00000168916 E017 5.2244894 0.020523902 9.527037e-03 0.0276045553 5 124744413 124744655 243 - 0.953 0.575 -1.533
ENSG00000168916 E018 7.8900076 0.002538770 4.410970e-02 0.0985860648 5 124744656 124745172 517 - 1.058 0.836 -0.833
ENSG00000168916 E019 0.4720498 0.208961643 7.138886e-01 0.8102570463 5 124745173 124745425 253 - 0.208 0.129 -0.825
ENSG00000168916 E020 0.5963950 0.129360815 3.373735e-01 0.4812504703 5 124746022 124746194 173 - 0.116 0.304 1.722
ENSG00000168916 E021 4.0746714 0.005740206 7.760908e-01 0.8558294517 5 124746195 124746639 445 - 0.698 0.738 0.165
ENSG00000168916 E022 0.8793535 0.152107557 5.205859e-01 0.6545355046 5 124748533 124748807 275 - 0.347 0.225 -0.852