ENSG00000168906

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306434 ENSG00000168906 HEK293_OSMI2_2hA HEK293_TMG_2hB MAT2A protein_coding protein_coding 227.0768 278.869 333.7908 20.60953 4.386571 0.259348 177.51224 258.90570 262.6312 19.5391558 5.75408169 0.02061075 0.751250 0.9282333 0.78666667 -0.14156667 2.503948e-32 2.503948e-32 FALSE TRUE
ENST00000409017 ENSG00000168906 HEK293_OSMI2_2hA HEK293_TMG_2hB MAT2A protein_coding protein_coding 227.0768 278.869 333.7908 20.60953 4.386571 0.259348 24.18313 11.09826 26.8688 0.4739023 0.07400536 1.27483551 0.130075 0.0404000 0.08053333 0.04013333 1.093770e-05 2.503948e-32 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168906 E001 0.000000       2 85537475 85537514 40 +      
ENSG00000168906 E002 8.323873 3.406349e-02 1.260751e-01 2.286893e-01 2 85537515 85539167 1653 + 1.028 0.880 -0.553
ENSG00000168906 E003 1.782089 9.965075e-03 1.480324e-01 2.589931e-01 2 85539168 85539172 5 + 0.524 0.320 -1.105
ENSG00000168906 E004 1659.388545 4.120195e-03 2.031441e-06 1.577967e-05 2 85539173 85539378 206 + 3.256 3.180 -0.253
ENSG00000168906 E005 2.046525 1.129593e-01 4.200164e-02 9.472834e-02 2 85539604 85539641 38 + 0.626 0.238 -2.142
ENSG00000168906 E006 2.960321 5.472238e-03 2.705259e-03 9.389060e-03 2 85539642 85539672 31 + 0.754 0.320 -2.106
ENSG00000168906 E007 12.972148 1.298294e-03 4.278700e-09 5.640435e-08 2 85539673 85540000 328 + 1.326 0.808 -1.893
ENSG00000168906 E008 1499.686910 4.085329e-03 1.018013e-04 5.302125e-04 2 85541083 85541160 78 + 3.200 3.151 -0.165
ENSG00000168906 E009 19.074018 1.042830e-03 9.489362e-16 3.593306e-14 2 85541161 85541254 94 + 1.509 0.876 -2.263
ENSG00000168906 E010 1797.988752 2.175072e-03 1.284055e-05 8.318300e-05 2 85541255 85541377 123 + 3.269 3.241 -0.094
ENSG00000168906 E011 39.878652 3.064057e-03 1.928483e-32 3.874287e-30 2 85541378 85541481 104 + 1.843 1.074 -2.663
ENSG00000168906 E012 49.231848 4.522677e-04 7.006460e-51 4.469202e-48 2 85541482 85541632 151 + 1.941 1.100 -2.896
ENSG00000168906 E013 1903.084114 9.737764e-04 1.060953e-08 1.301440e-07 2 85541633 85541745 113 + 3.291 3.270 -0.069
ENSG00000168906 E014 2417.432255 6.152676e-04 4.829185e-12 1.058760e-10 2 85541829 85541972 144 + 3.393 3.376 -0.058
ENSG00000168906 E015 44.732836 4.730393e-04 4.936790e-37 1.406406e-34 2 85541973 85542129 157 + 1.880 1.190 -2.370
ENSG00000168906 E016 3195.521162 2.105991e-04 1.594305e-14 5.107141e-13 2 85542155 85542373 219 + 3.502 3.510 0.026
ENSG00000168906 E017 96.818270 2.831203e-04 9.486772e-39 3.035879e-36 2 85542374 85542564 191 + 2.153 1.731 -1.418
ENSG00000168906 E018 2684.097425 3.738095e-04 3.104831e-02 7.400882e-02 2 85542565 85542747 183 + 3.404 3.455 0.169
ENSG00000168906 E019 1218.469712 3.922837e-04 2.586876e-01 3.959986e-01 2 85542901 85542966 66 + 3.057 3.117 0.199
ENSG00000168906 E020 1355.394587 7.812261e-05 3.804277e-01 5.247129e-01 2 85542967 85543034 68 + 3.100 3.168 0.225
ENSG00000168906 E021 144.887577 3.094688e-03 1.919111e-15 6.991587e-14 2 85543035 85543043 9 + 2.271 2.022 -0.833
ENSG00000168906 E022 568.342291 3.825161e-03 2.965395e-16 1.203224e-14 2 85543044 85543467 424 + 2.845 2.639 -0.684
ENSG00000168906 E023 280.944084 3.132825e-03 3.329463e-14 1.014078e-12 2 85543468 85543608 141 + 2.535 2.342 -0.644
ENSG00000168906 E024 11653.335178 3.279099e-03 1.662436e-17 7.915142e-16 2 85543670 85545281 1612 + 3.939 4.167 0.756