ENSG00000168876

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000534911 ENSG00000168876 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD49 protein_coding nonsense_mediated_decay 8.571788 2.407876 14.79883 0.2473701 0.3368651 2.614645 0.3847009 0.01908608 1.055107 0.01908608 0.10958925 5.194526 0.0303250 0.006633333 0.07106667 0.064433333 0.001530835 0.001530835 FALSE  
ENST00000544253 ENSG00000168876 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD49 protein_coding protein_coding 8.571788 2.407876 14.79883 0.2473701 0.3368651 2.614645 1.3533971 0.30919211 1.824270 0.02474347 0.05355836 2.522709 0.1768292 0.131200000 0.12356667 -0.007633333 1.000000000 0.001530835 FALSE  
ENST00000544612 ENSG00000168876 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD49 protein_coding protein_coding 8.571788 2.407876 14.79883 0.2473701 0.3368651 2.614645 5.4428662 1.76923506 9.764500 0.23381222 0.55377303 2.457766 0.6358625 0.730400000 0.65896667 -0.071433333 0.452037295 0.001530835 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168876 E001 6.7787571 0.0140551113 0.0222817948 0.056257419 11 94493979 94493983 5 + 0.848 0.404 -1.979
ENSG00000168876 E002 10.3807285 0.0016688789 0.0447946401 0.099827197 11 94493984 94494002 19 + 0.992 0.685 -1.196
ENSG00000168876 E003 8.7606480 0.0019006823 0.1362352680 0.242804245 11 94494003 94494003 1 + 0.919 0.685 -0.924
ENSG00000168876 E004 10.1748712 0.0016611694 0.9523683122 0.974155389 11 94494004 94494007 4 + 0.947 0.939 -0.029
ENSG00000168876 E005 22.0868945 0.0008474208 0.6366317949 0.750600459 11 94494008 94494028 21 + 1.260 1.214 -0.162
ENSG00000168876 E006 20.4886977 0.0008758730 0.8708705905 0.920994299 11 94494029 94494035 7 + 1.219 1.234 0.054
ENSG00000168876 E007 2.0618276 0.0072191939 0.0643182247 0.133896498 11 94494036 94494170 135 + 0.466 0.001 -9.596
ENSG00000168876 E008 0.2955422 0.0289936910 0.2115657614   11 94496600 94496603 4 + 0.056 0.247 2.480
ENSG00000168876 E009 52.5955664 0.0004467856 0.2963046949 0.437508071 11 94496604 94496754 151 + 1.628 1.561 -0.228
ENSG00000168876 E010 51.0032849 0.0005151365 0.7757903367 0.855602689 11 94496755 94496828 74 + 1.606 1.588 -0.063
ENSG00000168876 E011 65.4610432 0.0003982014 0.1028428225 0.194815109 11 94496829 94496951 123 + 1.724 1.629 -0.322
ENSG00000168876 E012 13.5327467 0.0038135630 0.0146235806 0.039647282 11 94496952 94497035 84 + 1.099 0.750 -1.324
ENSG00000168876 E013 10.1937386 0.0017978017 0.0499840655 0.109150265 11 94497036 94497056 21 + 0.986 0.685 -1.173
ENSG00000168876 E014 10.0697842 0.0020749312 0.0559632584 0.119633850 11 94497057 94497077 21 + 0.979 0.685 -1.150
ENSG00000168876 E015 9.7729943 0.0017780361 0.3017891867 0.443611208 11 94497078 94497118 41 + 0.954 0.805 -0.569
ENSG00000168876 E016 8.6788574 0.0020264818 0.3695077753 0.513920503 11 94497119 94497261 143 + 0.857 0.976 0.450
ENSG00000168876 E017 4.6564590 0.0035901922 0.4803388407 0.618630662 11 94497262 94497322 61 + 0.634 0.749 0.482
ENSG00000168876 E018 22.9132238 0.0098660890 0.3233040620 0.466612714 11 94497323 94497901 579 + 1.244 1.340 0.335
ENSG00000168876 E019 10.9894851 0.0016729115 0.0104912554 0.029957598 11 94497902 94497964 63 + 0.904 1.194 1.057
ENSG00000168876 E020 7.6718493 0.0021804214 0.5861441001 0.709763704 11 94497965 94498070 106 + 0.822 0.899 0.295
ENSG00000168876 E021 296.2273196 0.0002309236 0.0008956667 0.003598833 11 94498071 94499578 1508 + 2.347 2.411 0.215