ENSG00000168781

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334933 ENSG00000168781 HEK293_OSMI2_2hA HEK293_TMG_2hB PPIP5K1 protein_coding protein_coding 8.760639 7.97186 7.904126 0.7214523 0.5097114 -0.01229491 1.8655996 2.4538942 0.8504256 0.43163528 0.10756273 -1.5178180 0.20808333 0.30433333 0.1090000 -0.19533333 2.475108e-04 3.145824e-10 FALSE TRUE
ENST00000360135 ENSG00000168781 HEK293_OSMI2_2hA HEK293_TMG_2hB PPIP5K1 protein_coding protein_coding 8.760639 7.97186 7.904126 0.7214523 0.5097114 -0.01229491 0.2364910 0.5263684 0.0000000 0.07218258 0.00000000 -5.7451524 0.02723333 0.06583333 0.0000000 -0.06583333 3.145824e-10 3.145824e-10 FALSE TRUE
ENST00000360301 ENSG00000168781 HEK293_OSMI2_2hA HEK293_TMG_2hB PPIP5K1 protein_coding protein_coding 8.760639 7.97186 7.904126 0.7214523 0.5097114 -0.01229491 0.9962707 0.5890241 1.9123469 0.33916445 0.10541032 1.6821828 0.12445000 0.08083333 0.2427000 0.16186667 3.574358e-01 3.145824e-10 FALSE TRUE
ENST00000381885 ENSG00000168781 HEK293_OSMI2_2hA HEK293_TMG_2hB PPIP5K1 protein_coding protein_coding 8.760639 7.97186 7.904126 0.7214523 0.5097114 -0.01229491 1.3996347 1.6500764 1.0992584 0.30081191 0.28406688 -0.5816541 0.15824583 0.20696667 0.1407333 -0.06623333 5.837623e-01 3.145824e-10 FALSE TRUE
ENST00000427877 ENSG00000168781 HEK293_OSMI2_2hA HEK293_TMG_2hB PPIP5K1 protein_coding nonsense_mediated_decay 8.760639 7.97186 7.904126 0.7214523 0.5097114 -0.01229491 0.6811027 0.3366145 0.9086309 0.17439086 0.09801275 1.4061533 0.07655833 0.04056667 0.1143333 0.07376667 3.395297e-01 3.145824e-10 FALSE FALSE
ENST00000437065 ENSG00000168781 HEK293_OSMI2_2hA HEK293_TMG_2hB PPIP5K1 protein_coding protein_coding 8.760639 7.97186 7.904126 0.7214523 0.5097114 -0.01229491 0.5275483 0.6617216 0.2022020 0.29071116 0.20220197 -1.6624255 0.06307917 0.08693333 0.0231000 -0.06383333 2.538346e-01 3.145824e-10 FALSE FALSE
ENST00000469229 ENSG00000168781 HEK293_OSMI2_2hA HEK293_TMG_2hB PPIP5K1 protein_coding retained_intron 8.760639 7.97186 7.904126 0.7214523 0.5097114 -0.01229491 1.1883900 0.6737236 0.8279612 0.11058193 0.09935310 0.2934703 0.13148333 0.08346667 0.1072333 0.02376667 7.217148e-01 3.145824e-10 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168781 E001 0.1451727 0.0431314261 2.664321e-01   15 43533462 43533474 13 - 0.159 0.000 -11.265
ENSG00000168781 E002 181.1597219 0.0034486612 1.626469e-03 0.0060456814 15 43533475 43534456 982 - 2.143 2.263 0.400
ENSG00000168781 E003 36.4031347 0.0006200848 6.722762e-01 0.7782885999 15 43534457 43534482 26 - 1.515 1.548 0.113
ENSG00000168781 E004 29.7641442 0.0011067594 9.951567e-01 1.0000000000 15 43534483 43534493 11 - 1.446 1.453 0.026
ENSG00000168781 E005 43.7409529 0.0093622042 4.966999e-01 0.6333253283 15 43534494 43534536 43 - 1.575 1.631 0.189
ENSG00000168781 E006 30.8836134 0.0121120278 5.936686e-01 0.7160364573 15 43534537 43534540 4 - 1.432 1.485 0.184
ENSG00000168781 E007 44.9293470 0.0120050845 3.032986e-01 0.4451977428 15 43534541 43534571 31 - 1.565 1.652 0.295
ENSG00000168781 E008 90.0756140 0.0011234269 1.103074e-03 0.0043132635 15 43534572 43534808 237 - 1.818 1.962 0.484
ENSG00000168781 E009 59.3643444 0.0028838336 3.757711e-01 0.5201876129 15 43534809 43534940 132 - 1.706 1.760 0.183
ENSG00000168781 E010 66.7601166 0.0004359359 5.970413e-01 0.7188697826 15 43534941 43535069 129 - 1.807 1.791 -0.054
ENSG00000168781 E011 55.3943321 0.0004230164 1.147170e-01 0.2124189005 15 43535070 43535176 107 - 1.763 1.695 -0.230
ENSG00000168781 E012 27.9071884 0.0059288218 2.056625e-01 0.3332603700 15 43535177 43535195 19 - 1.491 1.405 -0.297
ENSG00000168781 E013 77.1521903 0.0016902092 5.753426e-01 0.7009719247 15 43535196 43535476 281 - 1.876 1.859 -0.054
ENSG00000168781 E014 1.5748466 0.0224268552 1.192275e-02 0.0333490316 15 43536135 43536254 120 - 0.000 0.500 14.481
ENSG00000168781 E015 21.3389073 0.0087805442 3.671449e-01 0.5115316497 15 43539470 43539482 13 - 1.371 1.303 -0.238
ENSG00000168781 E016 35.9283263 0.0032215501 4.293137e-01 0.5720542875 15 43539483 43539583 101 - 1.570 1.529 -0.142
ENSG00000168781 E017 0.0000000       15 43548407 43548683 277 -      
ENSG00000168781 E018 20.7014591 0.0024966020 3.527814e-01 0.4970354240 15 43558795 43558829 35 - 1.354 1.289 -0.227
ENSG00000168781 E019 20.3405312 0.0009634539 6.038525e-02 0.1272659052 15 43558830 43558932 103 - 1.387 1.251 -0.476
ENSG00000168781 E020 0.0000000       15 43560413 43560595 183 -      
ENSG00000168781 E021 2.3113073 0.0418356209 2.851528e-01 0.4254586397 15 43564103 43564165 63 - 0.611 0.429 -0.873
ENSG00000168781 E022 3.5386121 0.0054089298 6.463832e-01 0.7583126635 15 43564867 43564992 126 - 0.562 0.640 0.347
ENSG00000168781 E023 0.8825612 0.1917855093 3.267400e-01 0.4701926341 15 43568463 43568553 91 - 0.366 0.174 -1.424
ENSG00000168781 E024 0.0000000       15 43569068 43569185 118 -      
ENSG00000168781 E025 0.1451727 0.0431314261 2.664321e-01   15 43569186 43569335 150 - 0.159 0.000 -13.577
ENSG00000168781 E026 0.0000000       15 43571412 43571460 49 -      
ENSG00000168781 E027 0.0000000       15 43571461 43571576 116 -      
ENSG00000168781 E028 0.1515154 0.0424961240 2.664478e-01   15 43571724 43571840 117 - 0.159 0.000 -13.581
ENSG00000168781 E029 1.5144556 0.0098291028 4.162472e-01 0.5596172533 15 43572769 43572876 108 - 0.275 0.428 0.929
ENSG00000168781 E030 0.0000000       15 43572877 43573033 157 -      
ENSG00000168781 E031 1.5843854 0.0098476177 1.054394e-01 0.1987658227 15 43573034 43573088 55 - 0.159 0.466 2.123
ENSG00000168781 E032 1.4393145 0.0104979001 5.506739e-01 0.6802791053 15 43573089 43573112 24 - 0.275 0.388 0.709
ENSG00000168781 E033 1.8874163 0.0086079319 5.954938e-01 0.7175765433 15 43573113 43573148 36 - 0.366 0.466 0.538
ENSG00000168781 E034 0.1482932 0.0414732834 8.735258e-01   15 43573149 43573160 12 - 0.000 0.093 11.506
ENSG00000168781 E035 0.0000000       15 43573161 43573356 196 -      
ENSG00000168781 E036 0.1482932 0.0414732834 8.735258e-01   15 43573357 43573380 24 - 0.000 0.093 11.506
ENSG00000168781 E037 1.8874163 0.0086079319 5.954938e-01 0.7175765433 15 43573381 43573484 104 - 0.366 0.466 0.538
ENSG00000168781 E038 0.0000000       15 43573809 43573839 31 -      
ENSG00000168781 E039 0.0000000       15 43573840 43573933 94 -      
ENSG00000168781 E040 0.0000000       15 43573934 43574032 99 -      
ENSG00000168781 E041 0.0000000       15 43574222 43574363 142 -      
ENSG00000168781 E042 0.0000000       15 43574364 43574635 272 -      
ENSG00000168781 E043 0.0000000       15 43576168 43576370 203 -      
ENSG00000168781 E044 0.1482932 0.0414732834 8.735258e-01   15 43576371 43576553 183 - 0.000 0.093 11.506
ENSG00000168781 E045 0.0000000       15 43576827 43576948 122 -      
ENSG00000168781 E046 0.0000000       15 43577108 43577239 132 -      
ENSG00000168781 E047 0.1817044 0.0398623725 8.725818e-01   15 43577453 43577535 83 - 0.000 0.094 11.516
ENSG00000168781 E048 0.1817044 0.0398623725 8.725818e-01   15 43577622 43577731 110 - 0.000 0.094 11.516
ENSG00000168781 E049 0.1451727 0.0431314261 2.664321e-01   15 43577876 43577951 76 - 0.159 0.000 -13.577
ENSG00000168781 E050 0.6256415 0.0175404684 1.057796e-01 0.1992802826 15 43578070 43578156 87 - 0.366 0.093 -2.462
ENSG00000168781 E051 1.2994549 0.0114801160 3.868416e-01 0.5310039012 15 43579019 43579073 55 - 0.442 0.292 -0.878
ENSG00000168781 E052 1.7004144 0.0083049162 7.390349e-01 0.8287730920 15 43579074 43579120 47 - 0.442 0.388 -0.292
ENSG00000168781 E053 6.9394686 0.0059285700 5.948585e-01 0.7170344215 15 43581002 43581123 122 - 0.906 0.846 -0.232
ENSG00000168781 E054 17.6189811 0.0630030067 1.660159e-01 0.2830181207 15 43581227 43581388 162 - 1.355 1.171 -0.650
ENSG00000168781 E055 3.6139593 0.0046990433 6.926249e-03 0.0210311914 15 43581389 43581429 41 - 0.856 0.466 -1.683
ENSG00000168781 E056 0.0000000       15 43581688 43581852 165 -      
ENSG00000168781 E057 9.2004154 0.0063421359 5.064679e-02 0.1103075595 15 43581853 43581954 102 - 1.111 0.901 -0.773
ENSG00000168781 E058 1.9424862 0.0484289030 3.264630e-01 0.4699046868 15 43582095 43582249 155 - 0.562 0.387 -0.876
ENSG00000168781 E059 0.1817044 0.0398623725 8.725818e-01   15 43582564 43582649 86 - 0.000 0.094 11.516
ENSG00000168781 E060 0.0000000       15 43582750 43582861 112 -      
ENSG00000168781 E061 0.1817044 0.0398623725 8.725818e-01   15 43582862 43582895 34 - 0.000 0.094 11.516
ENSG00000168781 E062 0.4804688 0.0209373434 2.688100e-01 0.4072814304 15 43582896 43582952 57 - 0.275 0.093 -1.877
ENSG00000168781 E063 0.5891098 0.0184276118 7.475531e-03 0.0224504127 15 43583404 43583531 128 - 0.442 0.000 -15.591
ENSG00000168781 E064 1.4986628 0.0965601638 9.082532e-01 0.9457144031 15 43583532 43583599 68 - 0.366 0.387 0.124
ENSG00000168781 E065 10.0882620 0.0042816080 1.387943e-02 0.0379540208 15 43584358 43584532 175 - 1.166 0.914 -0.923
ENSG00000168781 E066 3.6117667 0.0146443596 2.562745e-01 0.3932291902 15 43584533 43584589 57 - 0.733 0.563 -0.734
ENSG00000168781 E067 2.4691247 0.0655617753 5.924551e-01 0.7150018259 15 43584590 43584621 32 - 0.562 0.470 -0.440
ENSG00000168781 E068 8.8089852 0.0020914059 5.991757e-05 0.0003310547 15 43584799 43584892 94 - 1.204 0.781 -1.572
ENSG00000168781 E069 0.5202097 0.0206376275 2.693902e-01 0.4079060484 15 43589882 43589901 20 - 0.275 0.094 -1.875
ENSG00000168781 E070 0.3686942 0.0307662590 6.505507e-01 0.7615831950 15 43589902 43590171 270 - 0.159 0.094 -0.874
ENSG00000168781 E071 8.3380657 0.0021204391 1.569864e-03 0.0058616050 15 43590172 43590208 37 - 1.140 0.798 -1.275