ENSG00000168769

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265149 ENSG00000168769 HEK293_OSMI2_2hA HEK293_TMG_2hB TET2 protein_coding nonsense_mediated_decay 2.537697 0.8109222 3.533495 0.06706958 0.1049512 2.109856 0.1903640 0.04823073 0.1470844 0.04823073 0.08051741 1.43168682 0.05564583 0.05486667 0.04113333 -0.01373333 9.909766e-01 4.881803e-05 TRUE TRUE
ENST00000380013 ENSG00000168769 HEK293_OSMI2_2hA HEK293_TMG_2hB TET2 protein_coding protein_coding 2.537697 0.8109222 3.533495 0.06706958 0.1049512 2.109856 0.7586681 0.09541848 1.3947541 0.09541848 0.31099190 3.73611784 0.24526250 0.10880000 0.40056667 0.29176667 2.091253e-01 4.881803e-05 FALSE TRUE
MSTRG.25262.4 ENSG00000168769 HEK293_OSMI2_2hA HEK293_TMG_2hB TET2 protein_coding   2.537697 0.8109222 3.533495 0.06706958 0.1049512 2.109856 0.6468681 0.02405277 1.1420963 0.02405277 0.23790412 5.08034527 0.18744583 0.03553333 0.32033333 0.28480000 7.654635e-03 4.881803e-05 FALSE TRUE
MSTRG.25262.8 ENSG00000168769 HEK293_OSMI2_2hA HEK293_TMG_2hB TET2 protein_coding   2.537697 0.8109222 3.533495 0.06706958 0.1049512 2.109856 0.8070639 0.62047978 0.6412121 0.05131591 0.19590693 0.04667731 0.45832083 0.77283333 0.17896667 -0.59386667 4.881803e-05 4.881803e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168769 E001 0.000000       4 105145875 105146086 212 +      
ENSG00000168769 E002 1.035123 0.011952143 2.771365e-01 4.166449e-01 4 105146293 105146785 493 + 0.248 0.000 -15.051
ENSG00000168769 E003 1.186639 0.010804993 2.196112e-01 3.499103e-01 4 105146786 105146874 89 + 0.274 0.000 -15.243
ENSG00000168769 E004 1.035123 0.011952143 2.771365e-01 4.166449e-01 4 105146875 105146875 1 + 0.248 0.000 -15.050
ENSG00000168769 E005 1.035123 0.011952143 2.771365e-01 4.166449e-01 4 105146876 105146877 2 + 0.248 0.000 -15.050
ENSG00000168769 E006 1.630576 0.008394606 1.148673e-01 2.126432e-01 4 105146878 105146885 8 + 0.344 0.000 -15.702
ENSG00000168769 E007 5.794915 0.003060742 8.539414e-03 2.513777e-02 4 105146886 105146932 47 + 0.714 0.293 -2.117
ENSG00000168769 E008 7.122359 0.007697812 6.036608e-02 1.272349e-01 4 105146933 105146979 47 + 0.774 0.590 -0.777
ENSG00000168769 E009 0.000000       4 105147457 105147799 343 +      
ENSG00000168769 E010 6.825557 0.058117034 1.315040e-01 2.362376e-01 4 105190360 105190486 127 + 0.758 0.588 -0.718
ENSG00000168769 E011 4.159959 0.105284864 9.849613e-02 1.882033e-01 4 105190487 105190505 19 + 0.598 0.293 -1.620
ENSG00000168769 E012 0.000000       4 105190506 105190703 198 +      
ENSG00000168769 E013 0.000000       4 105202340 105202546 207 +      
ENSG00000168769 E014 122.513770 0.014333308 1.115112e-08 1.362581e-07 4 105233897 105237351 3455 + 1.928 1.728 -0.672
ENSG00000168769 E015 2.524689 0.013201101 1.127693e-01 2.095868e-01 4 105237352 105241338 3987 + 0.344 0.764 1.992
ENSG00000168769 E016 9.684473 0.002302733 5.440173e-01 6.745278e-01 4 105241339 105241429 91 + 0.855 0.940 0.323
ENSG00000168769 E017 1.633707 0.047391416 7.054473e-02 1.442470e-01 4 105241430 105242771 1342 + 0.220 0.687 2.546
ENSG00000168769 E018 12.524475 0.006392957 2.843660e-01 4.246025e-01 4 105242834 105242927 94 + 0.955 0.986 0.114
ENSG00000168769 E019 15.556907 0.001510635 5.099187e-02 1.109316e-01 4 105243570 105243778 209 + 1.054 0.985 -0.254
ENSG00000168769 E020 15.084306 0.001142483 1.198731e-02 3.350338e-02 4 105259619 105259769 151 + 1.050 0.889 -0.601
ENSG00000168769 E021 11.874551 0.001487581 1.485420e-02 4.016324e-02 4 105261759 105261848 90 + 0.961 0.765 -0.757
ENSG00000168769 E022 14.981572 0.009063346 5.239345e-04 2.249163e-03 4 105269610 105269747 138 + 1.063 0.686 -1.455
ENSG00000168769 E023 24.952615 0.005447833 6.284766e-03 1.935952e-02 4 105272564 105272918 355 + 1.249 1.131 -0.416
ENSG00000168769 E024 261.186359 0.024526751 6.395959e-11 1.164644e-09 4 105275048 105279816 4769 + 2.153 2.582 1.430