ENSG00000168763

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000305510 ENSG00000168763 HEK293_OSMI2_2hA HEK293_TMG_2hB CNNM3 protein_coding protein_coding 32.49409 40.09131 23.95418 1.788481 0.6012286 -0.7427698 19.294327 21.453317 16.013735 1.3237343 0.4094955 -0.4216626 0.60445833 0.53436667 0.6685000 0.13413333 2.269893e-06 1.130658e-11 FALSE TRUE
ENST00000377060 ENSG00000168763 HEK293_OSMI2_2hA HEK293_TMG_2hB CNNM3 protein_coding protein_coding 32.49409 40.09131 23.95418 1.788481 0.6012286 -0.7427698 2.774075 1.916462 3.263081 0.4322132 0.4226329 0.7646960 0.09029583 0.04753333 0.1361667 0.08863333 2.143858e-03 1.130658e-11 FALSE TRUE
ENST00000480035 ENSG00000168763 HEK293_OSMI2_2hA HEK293_TMG_2hB CNNM3 protein_coding processed_transcript 32.49409 40.09131 23.95418 1.788481 0.6012286 -0.7427698 8.874395 15.550032 3.218184 0.7262142 0.2935540 -2.2690502 0.25566250 0.38893333 0.1345667 -0.25436667 1.130658e-11 1.130658e-11 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168763 E001 0.0000000       2 96814978 96815081 104 +      
ENSG00000168763 E002 0.0000000       2 96815082 96815140 59 +      
ENSG00000168763 E003 0.1817044 0.0397761510 7.230166e-01   2 96815141 96816013 873 + 0.000 0.101 7.839
ENSG00000168763 E004 0.3299976 0.0274424043 3.476844e-01   2 96816014 96816244 231 + 0.000 0.183 10.908
ENSG00000168763 E005 8.1468517 0.0050294471 1.718358e-03 6.340080e-03 2 96816245 96816267 23 + 1.143 0.796 -1.296
ENSG00000168763 E006 478.5735308 0.0018881647 1.783562e-17 8.462071e-16 2 96816268 96817502 1235 + 2.777 2.576 -0.669
ENSG00000168763 E007 297.5134737 0.0008070813 3.130176e-03 1.064866e-02 2 96825058 96825174 117 + 2.490 2.426 -0.212
ENSG00000168763 E008 195.9690811 0.0009054216 1.413098e-01 2.498341e-01 2 96825175 96825201 27 + 2.290 2.255 -0.117
ENSG00000168763 E009 297.2412329 0.0028617156 7.422522e-01 8.311952e-01 2 96826833 96826982 150 + 2.450 2.451 0.002
ENSG00000168763 E010 389.8247728 0.0039175235 9.399232e-01 9.662881e-01 2 96827731 96827900 170 + 2.562 2.572 0.033
ENSG00000168763 E011 4.9519815 0.0377389562 2.400478e-01 3.742046e-01 2 96827901 96828098 198 + 0.848 0.674 -0.699
ENSG00000168763 E012 331.6315407 0.0011735474 4.798928e-01 6.182287e-01 2 96828099 96828195 97 + 2.480 2.507 0.089
ENSG00000168763 E013 20.2817880 0.0009005382 1.538614e-06 1.226740e-05 2 96828196 96828565 370 + 1.500 1.143 -1.249
ENSG00000168763 E014 6.2885500 0.0027234585 1.400300e-02 3.823399e-02 2 96828566 96828566 1 + 1.011 0.717 -1.139
ENSG00000168763 E015 338.6179446 0.0001662856 2.574601e-01 3.945795e-01 2 96828567 96828700 134 + 2.486 2.515 0.099
ENSG00000168763 E016 5.1098950 0.0399592298 2.686046e-02 6.570388e-02 2 96828701 96828995 295 + 0.958 0.618 -1.356
ENSG00000168763 E017 339.6943145 0.0002195695 7.035360e-02 1.439417e-01 2 96828996 96829134 139 + 2.477 2.521 0.147
ENSG00000168763 E018 18.3587670 0.0147010541 4.492728e-01 5.904670e-01 2 96831969 96832068 100 + 1.300 1.235 -0.226
ENSG00000168763 E019 1173.2787613 0.0008353493 7.298239e-16 2.807940e-14 2 96832552 96833478 927 + 2.960 3.089 0.430
ENSG00000168763 E020 552.3410058 0.0005768202 2.013389e-05 1.247747e-04 2 96833479 96834389 911 + 2.764 2.696 -0.228
ENSG00000168763 E021 83.8214603 0.0087891612 4.753503e-01 6.140597e-01 2 96834390 96834487 98 + 1.876 1.928 0.177
ENSG00000168763 E022 459.3833519 0.0085637727 1.232634e-01 2.246324e-01 2 96834488 96835454 967 + 2.588 2.670 0.272
ENSG00000168763 E023 22.3538696 0.0259695087 1.185205e-01 2.178204e-01 2 96836944 96837703 760 + 1.223 1.409 0.651