ENSG00000168758

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000474420 ENSG00000168758 HEK293_OSMI2_2hA HEK293_TMG_2hB SEMA4C protein_coding retained_intron 11.74942 11.90646 10.5028 0.9966113 0.3903356 -0.1808082 0.8321401 0.6340541 0.8424433 0.14161167 0.1842826 0.40442205 0.07042083 0.05206667 0.0805000 0.02843333 0.546977234 0.001264618 FALSE TRUE
ENST00000482925 ENSG00000168758 HEK293_OSMI2_2hA HEK293_TMG_2hB SEMA4C protein_coding retained_intron 11.74942 11.90646 10.5028 0.9966113 0.3903356 -0.1808082 1.2206434 0.8279463 1.2676720 0.05203182 0.2497041 0.60858780 0.10237083 0.06983333 0.1193667 0.04953333 0.178049686 0.001264618 FALSE TRUE
MSTRG.18895.3 ENSG00000168758 HEK293_OSMI2_2hA HEK293_TMG_2hB SEMA4C protein_coding   11.74942 11.90646 10.5028 0.9966113 0.3903356 -0.1808082 2.8792134 4.6637395 2.2215903 0.80695269 0.1696369 -1.06650511 0.24769167 0.38606667 0.2111000 -0.17496667 0.001264618 0.001264618 FALSE TRUE
MSTRG.18895.5 ENSG00000168758 HEK293_OSMI2_2hA HEK293_TMG_2hB SEMA4C protein_coding   11.74942 11.90646 10.5028 0.9966113 0.3903356 -0.1808082 2.2510115 2.1100473 1.4272700 0.11993692 0.2032014 -0.56076537 0.18400417 0.17986667 0.1368000 -0.04306667 0.537557385 0.001264618 FALSE TRUE
MSTRG.18895.7 ENSG00000168758 HEK293_OSMI2_2hA HEK293_TMG_2hB SEMA4C protein_coding   11.74942 11.90646 10.5028 0.9966113 0.3903356 -0.1808082 3.4001543 2.9085397 3.0925964 0.08857974 0.3953384 0.08822932 0.29357083 0.24656667 0.2962667 0.04970000 0.695249706 0.001264618 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168758 E001 0.0000000       2 96859718 96859735 18 -      
ENSG00000168758 E002 0.5514428 0.0196670196 1.393439e-01 2.471514e-01 2 96859736 96859741 6 - 0.000 0.268 10.619
ENSG00000168758 E003 0.5514428 0.0196670196 1.393439e-01 2.471514e-01 2 96859742 96859747 6 - 0.000 0.268 10.621
ENSG00000168758 E004 131.4055955 0.0030388935 5.628707e-05 3.130958e-04 2 96859748 96860308 561 - 1.993 2.169 0.590
ENSG00000168758 E005 327.7725255 0.0031773639 2.844016e-03 9.806671e-03 2 96860309 96861045 737 - 2.434 2.541 0.357
ENSG00000168758 E006 174.1409255 0.0066064739 4.676998e-02 1.034146e-01 2 96861046 96861455 410 - 2.160 2.267 0.360
ENSG00000168758 E007 8.2848187 0.0062238695 3.922806e-01 5.362241e-01 2 96861456 96861578 123 - 0.998 0.910 -0.329
ENSG00000168758 E008 76.9065476 0.0064901938 5.117327e-01 6.466899e-01 2 96861579 96861649 71 - 1.883 1.866 -0.056
ENSG00000168758 E009 96.2835699 0.0003015113 5.164709e-01 6.510378e-01 2 96861737 96861894 158 - 1.948 1.983 0.120
ENSG00000168758 E010 30.0559485 0.0006531354 5.112558e-06 3.630825e-05 2 96861895 96863328 1434 - 1.623 1.349 -0.944
ENSG00000168758 E011 70.0324966 0.0003985729 2.707077e-02 6.613547e-02 2 96863682 96863794 113 - 1.767 1.874 0.364
ENSG00000168758 E012 121.5515122 0.0006035400 4.717157e-01 6.107847e-01 2 96863926 96864148 223 - 2.047 2.083 0.122
ENSG00000168758 E013 87.9572578 0.0016636645 7.086143e-01 8.062415e-01 2 96864238 96864382 145 - 1.935 1.931 -0.011
ENSG00000168758 E014 95.8211541 0.0003264958 7.758204e-01 8.556246e-01 2 96864705 96864880 176 - 1.967 1.969 0.006
ENSG00000168758 E015 105.6222586 0.0002881643 4.692789e-02 1.036933e-01 2 96864964 96865115 152 - 2.047 1.991 -0.188
ENSG00000168758 E016 67.0245374 0.0077321638 2.054742e-02 5.264603e-02 2 96865204 96865233 30 - 1.895 1.771 -0.418
ENSG00000168758 E017 96.3090578 0.0004473657 4.734797e-04 2.058740e-03 2 96865234 96865320 87 - 2.042 1.928 -0.383
ENSG00000168758 E018 88.3538466 0.0057243084 3.610155e-01 5.053891e-01 2 96865441 96865537 97 - 1.960 1.926 -0.117
ENSG00000168758 E019 40.3373236 0.0029866828 6.944795e-01 7.952939e-01 2 96865666 96865666 1 - 1.583 1.619 0.122
ENSG00000168758 E020 80.1674443 0.0006815234 2.482898e-01 3.839158e-01 2 96865667 96865764 98 - 1.917 1.882 -0.117
ENSG00000168758 E021 65.2515872 0.0004337463 4.179291e-02 9.434967e-02 2 96865867 96865929 63 - 1.852 1.775 -0.260
ENSG00000168758 E022 75.1878312 0.0016922877 1.552812e-02 4.168800e-02 2 96866283 96866431 149 - 1.921 1.826 -0.319
ENSG00000168758 E023 10.8573681 0.0031280147 1.278047e-02 3.539751e-02 2 96866432 96866930 499 - 1.192 0.952 -0.870
ENSG00000168758 E024 51.4695418 0.0004893617 1.430980e-01 2.522457e-01 2 96867778 96867923 146 - 1.738 1.678 -0.204
ENSG00000168758 E025 13.4322091 0.0071273441 1.849337e-01 3.074023e-01 2 96867924 96867926 3 - 1.202 1.084 -0.421
ENSG00000168758 E026 8.4537102 0.0049501668 3.094114e-01 4.517031e-01 2 96868416 96868588 173 - 0.887 1.015 0.480
ENSG00000168758 E027 17.9376316 0.0077736810 9.532763e-01 9.747737e-01 2 96869187 96869469 283 - 1.241 1.260 0.067
ENSG00000168758 E028 8.2586742 0.0021574879 2.858591e-03 9.849077e-03 2 96869876 96870310 435 - 1.124 0.806 -1.189
ENSG00000168758 E029 0.0000000       2 96870378 96870757 380 -