ENSG00000168710

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369799 ENSG00000168710 HEK293_OSMI2_2hA HEK293_TMG_2hB AHCYL1 protein_coding protein_coding 43.49672 37.89454 53.10911 5.584459 2.47923 0.4868602 20.114460 10.3516366 31.629180 1.04279848 2.4361382 1.6104603 0.45254167 0.27863333 0.60193333 0.323300000 3.124428e-03 1.18064e-37 FALSE TRUE
ENST00000475081 ENSG00000168710 HEK293_OSMI2_2hA HEK293_TMG_2hB AHCYL1 protein_coding processed_transcript 43.49672 37.89454 53.10911 5.584459 2.47923 0.4868602 2.934727 0.1927292 6.063830 0.19272923 3.2922409 4.9049804 0.05840833 0.00520000 0.10896667 0.103766667 4.144317e-01 1.18064e-37 TRUE TRUE
ENST00000481423 ENSG00000168710 HEK293_OSMI2_2hA HEK293_TMG_2hB AHCYL1 protein_coding processed_transcript 43.49672 37.89454 53.10911 5.584459 2.47923 0.4868602 6.361553 15.5664041 0.000000 3.90168750 0.0000000 -10.6051465 0.15892500 0.40383333 0.00000000 -0.403833333 1.180640e-37 1.18064e-37   FALSE
MSTRG.1771.3 ENSG00000168710 HEK293_OSMI2_2hA HEK293_TMG_2hB AHCYL1 protein_coding   43.49672 37.89454 53.10911 5.584459 2.47923 0.4868602 2.749333 0.9469181 3.641799 0.09141391 0.6624863 1.9321399 0.06189167 0.02603333 0.06773333 0.041700000 6.127284e-03 1.18064e-37 TRUE TRUE
MSTRG.1771.4 ENSG00000168710 HEK293_OSMI2_2hA HEK293_TMG_2hB AHCYL1 protein_coding   43.49672 37.89454 53.10911 5.584459 2.47923 0.4868602 5.047300 3.8432906 6.106583 0.47956195 0.3658648 0.6666349 0.11731250 0.10576667 0.11543333 0.009666667 8.626940e-01 1.18064e-37 TRUE TRUE
MSTRG.1771.7 ENSG00000168710 HEK293_OSMI2_2hA HEK293_TMG_2hB AHCYL1 protein_coding   43.49672 37.89454 53.10911 5.584459 2.47923 0.4868602 5.645269 6.8987790 4.857688 1.58620706 0.5987444 -0.5051940 0.13577500 0.17760000 0.09093333 -0.086666667 9.693088e-03 1.18064e-37 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168710 E001 54.2766453 0.0008051829 8.285401e-05 4.415563e-04 1 109984765 109985002 238 + 1.765 1.671 -0.319
ENSG00000168710 E002 7.8769264 0.0020557727 1.975199e-06 1.538443e-05 1 109985003 109985005 3 + 1.073 0.518 -2.240
ENSG00000168710 E003 8.0618504 0.0020619109 2.144696e-04 1.026181e-03 1 109985006 109985014 9 + 1.047 0.670 -1.466
ENSG00000168710 E004 195.2111113 0.0042032860 1.890832e-05 1.179300e-04 1 109985015 109985172 158 + 2.308 2.233 -0.251
ENSG00000168710 E005 0.7405235 0.0150392362 9.795007e-01 9.912325e-01 1 109985173 109985543 371 + 0.228 0.282 0.405
ENSG00000168710 E006 0.0000000       1 110004131 110004451 321 +      
ENSG00000168710 E007 269.0485699 0.0012901544 1.625022e-11 3.268106e-10 1 110009034 110009145 112 + 2.451 2.366 -0.284
ENSG00000168710 E008 319.4625071 0.0019072460 9.706223e-11 1.716113e-09 1 110011214 110011357 144 + 2.526 2.440 -0.286
ENSG00000168710 E009 155.7408286 0.0003606518 1.587258e-07 1.551126e-06 1 110012362 110012386 25 + 2.204 2.153 -0.170
ENSG00000168710 E010 251.8177667 0.0024999806 2.498477e-08 2.857922e-07 1 110012387 110012462 76 + 2.422 2.337 -0.282
ENSG00000168710 E011 260.8272394 0.0030617713 8.997549e-06 6.046035e-05 1 110012897 110012999 103 + 2.427 2.373 -0.179
ENSG00000168710 E012 251.6731374 0.0006041193 2.550960e-09 3.507815e-08 1 110014763 110014857 95 + 2.409 2.363 -0.154
ENSG00000168710 E013 249.6810762 0.0003740188 4.454128e-08 4.853452e-07 1 110015425 110015531 107 + 2.401 2.375 -0.084
ENSG00000168710 E014 215.9175571 0.0024758882 3.329574e-04 1.512076e-03 1 110016344 110016460 117 + 2.334 2.317 -0.057
ENSG00000168710 E015 209.0557278 0.0005477198 2.696214e-05 1.621812e-04 1 110016667 110016730 64 + 2.318 2.314 -0.014
ENSG00000168710 E016 195.1239299 0.0011912795 5.312936e-04 2.276679e-03 1 110017495 110017583 89 + 2.284 2.286 0.006
ENSG00000168710 E017 197.6591270 0.0001744301 9.636809e-05 5.050108e-04 1 110017946 110018016 71 + 2.287 2.294 0.024
ENSG00000168710 E018 220.8541645 0.0002269652 1.872420e-06 1.465985e-05 1 110018373 110018431 59 + 2.341 2.330 -0.037
ENSG00000168710 E019 202.4369324 0.0006135550 1.028403e-03 4.056634e-03 1 110018432 110018467 36 + 2.292 2.308 0.052
ENSG00000168710 E020 253.6676730 0.0014425360 2.277035e-02 5.726958e-02 1 110018552 110018650 99 + 2.381 2.418 0.125
ENSG00000168710 E021 5.2716792 0.2302935842 1.402586e-01 2.483720e-01 1 110018651 110018874 224 + 0.858 0.594 -1.086
ENSG00000168710 E022 18.5092022 0.0098685784 2.422400e-04 1.142663e-03 1 110018875 110019050 176 + 1.360 1.096 -0.933
ENSG00000168710 E023 233.7934057 0.0026654194 1.591172e-02 4.253581e-02 1 110019051 110019119 69 + 2.353 2.370 0.060
ENSG00000168710 E024 242.9609849 0.0002698619 1.149714e-02 3.234239e-02 1 110019548 110019626 79 + 2.360 2.407 0.158
ENSG00000168710 E025 238.6949290 0.0016679407 1.301236e-01 2.343323e-01 1 110020731 110020851 121 + 2.347 2.405 0.194
ENSG00000168710 E026 2385.1450417 0.0041440718 6.052020e-25 6.596876e-23 1 110021674 110023742 2069 + 3.216 3.535 1.060