ENSG00000168610

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264657 ENSG00000168610 HEK293_OSMI2_2hA HEK293_TMG_2hB STAT3 protein_coding protein_coding 16.71846 17.15704 15.58641 0.9798265 0.37755 -0.138428 6.7724660 9.530967 4.161324 1.1003495 0.6414648 -1.1936302 0.40129583 0.55213333 0.26830000 -0.28383333 2.340018e-03 3.427709e-30 FALSE TRUE
ENST00000588969 ENSG00000168610 HEK293_OSMI2_2hA HEK293_TMG_2hB STAT3 protein_coding protein_coding 16.71846 17.15704 15.58641 0.9798265 0.37755 -0.138428 1.5128114 0.000000 2.936386 0.0000000 0.3176151 8.2028027 0.09400417 0.00000000 0.18773333 0.18773333 3.427709e-30 3.427709e-30 FALSE TRUE
ENST00000677723 ENSG00000168610 HEK293_OSMI2_2hA HEK293_TMG_2hB STAT3 protein_coding protein_coding 16.71846 17.15704 15.58641 0.9798265 0.37755 -0.138428 1.1659467 1.331962 1.067638 0.9491884 1.0676378 -0.3164720 0.07213750 0.08323333 0.06626667 -0.01696667 6.334429e-01 3.427709e-30 FALSE TRUE
ENST00000678044 ENSG00000168610 HEK293_OSMI2_2hA HEK293_TMG_2hB STAT3 protein_coding protein_coding 16.71846 17.15704 15.58641 0.9798265 0.37755 -0.138428 2.7019285 2.373398 2.672608 0.4901688 0.5928978 0.1706164 0.16046250 0.13593333 0.17133333 0.03540000 7.649403e-01 3.427709e-30 FALSE TRUE
ENST00000678674 ENSG00000168610 HEK293_OSMI2_2hA HEK293_TMG_2hB STAT3 protein_coding protein_coding 16.71846 17.15704 15.58641 0.9798265 0.37755 -0.138428 0.7077474 2.012663 0.000000 1.0063559 0.0000000 -7.6601121 0.03956250 0.11180000 0.00000000 -0.11180000 1.436613e-01 3.427709e-30 FALSE TRUE
ENST00000679014 ENSG00000168610 HEK293_OSMI2_2hA HEK293_TMG_2hB STAT3 protein_coding protein_coding 16.71846 17.15704 15.58641 0.9798265 0.37755 -0.138428 0.7562519 0.000000 1.492742 0.0000000 0.7817497 7.2314532 0.04600000 0.00000000 0.09803333 0.09803333 1.819863e-01 3.427709e-30 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168610 E001 26.3020417 0.0098296464 8.978044e-09 1.116418e-07 17 42313324 42313411 88 - 1.008 1.570 1.975
ENSG00000168610 E002 19.1728233 0.0081932543 2.635675e-04 1.231188e-03 17 42313412 42313420 9 - 1.039 1.406 1.298
ENSG00000168610 E003 31.8384490 0.0006964560 7.461470e-10 1.133563e-08 17 42313421 42313445 25 - 1.181 1.631 1.560
ENSG00000168610 E004 73.3570648 0.0087275924 7.455742e-11 1.342778e-09 17 42313446 42313470 25 - 1.530 1.981 1.525
ENSG00000168610 E005 689.1579154 0.0021359564 2.911831e-15 1.038670e-13 17 42313471 42314847 1377 - 2.687 2.892 0.684
ENSG00000168610 E006 41.5711799 0.0021656893 1.879340e-03 6.850652e-03 17 42314848 42314853 6 - 1.473 1.677 0.698
ENSG00000168610 E007 66.9130703 0.0036336396 1.498001e-02 4.044290e-02 17 42314854 42314902 49 - 1.721 1.864 0.482
ENSG00000168610 E008 278.1998372 0.0011767978 5.215540e-06 3.695648e-05 17 42314903 42315467 565 - 2.341 2.478 0.454
ENSG00000168610 E009 71.9360678 0.0031834485 4.688007e-01 6.081678e-01 17 42315468 42315490 23 - 1.815 1.864 0.165
ENSG00000168610 E010 70.7673789 0.0030186251 6.627679e-01 7.710031e-01 17 42315491 42315510 20 - 1.818 1.852 0.117
ENSG00000168610 E011 92.8062169 0.0006029057 5.822113e-01 7.066093e-01 17 42315511 42315558 48 - 1.961 1.954 -0.023
ENSG00000168610 E012 97.3323831 0.0003104389 2.806690e-02 6.814550e-02 17 42315559 42315596 38 - 2.018 1.953 -0.218
ENSG00000168610 E013 179.2096574 0.0020668931 2.427935e-01 3.774629e-01 17 42315597 42315800 204 - 2.260 2.235 -0.085
ENSG00000168610 E014 107.6094087 0.0054104455 8.678073e-01 9.189738e-01 17 42316789 42316851 63 - 2.021 2.028 0.022
ENSG00000168610 E015 87.6770288 0.0023095467 1.696866e-01 2.877942e-01 17 42316852 42316889 38 - 1.889 1.967 0.261
ENSG00000168610 E016 79.2436182 0.0030393455 2.675511e-01 4.058837e-01 17 42316890 42316901 12 - 1.851 1.922 0.236
ENSG00000168610 E017 0.9609246 0.0122137780 2.131364e-01 3.422448e-01 17 42316902 42317181 280 - 0.403 0.191 -1.467
ENSG00000168610 E018 107.6414691 0.0005948691 3.392481e-01 4.831541e-01 17 42317182 42317224 43 - 1.995 2.045 0.167
ENSG00000168610 E019 0.7739347 0.0147821082 4.006554e-01 5.443297e-01 17 42317225 42317326 102 - 0.332 0.191 -1.054
ENSG00000168610 E020 2.5903770 0.0056759018 4.796890e-01 6.180209e-01 17 42317327 42317703 377 - 0.609 0.507 -0.468
ENSG00000168610 E021 2.0585036 0.1237243996 2.032938e-02 5.217627e-02 17 42319856 42320073 218 - 0.716 0.259 -2.367
ENSG00000168610 E022 2.5315194 0.0188405755 7.928095e-01 8.675150e-01 17 42321156 42321953 798 - 0.518 0.575 0.264
ENSG00000168610 E023 2.7552444 0.0142089266 1.584699e-01 2.730879e-01 17 42321954 42322281 328 - 0.684 0.468 -0.981
ENSG00000168610 E024 56.3749050 0.0006113725 8.141590e-01 8.822485e-01 17 42322282 42322284 3 - 1.731 1.757 0.088
ENSG00000168610 E025 190.0777485 0.0011700617 2.412586e-01 3.756655e-01 17 42322285 42322494 210 - 2.238 2.288 0.169
ENSG00000168610 E026 91.8979152 0.0017370762 1.975956e-01 3.232047e-01 17 42323004 42323034 31 - 1.913 1.982 0.233
ENSG00000168610 E027 90.1004050 0.0003491373 6.046547e-01 7.251029e-01 17 42323035 42323063 29 - 1.926 1.961 0.117
ENSG00000168610 E028 122.0021023 0.0002891065 9.151791e-01 9.503025e-01 17 42323064 42323143 80 - 2.067 2.085 0.062
ENSG00000168610 E029 1.1135859 0.0116114595 1.593755e-02 4.259224e-02 17 42323144 42323259 116 - 0.518 0.106 -3.052
ENSG00000168610 E030 83.8122572 0.0003496450 2.871210e-01 4.275997e-01 17 42323260 42323286 27 - 1.932 1.905 -0.091
ENSG00000168610 E031 116.1892233 0.0002705319 2.058056e-01 3.334181e-01 17 42323287 42323354 68 - 2.072 2.045 -0.092
ENSG00000168610 E032 2.5608440 0.0998043696 5.946694e-03 1.846798e-02 17 42323355 42323452 98 - 0.802 0.262 -2.690
ENSG00000168610 E033 4.2941049 0.0036761283 2.521856e-03 8.828247e-03 17 42323453 42323572 120 - 0.918 0.507 -1.715
ENSG00000168610 E034 100.3596271 0.0002906874 2.088663e-02 5.334992e-02 17 42323573 42323625 53 - 2.034 1.967 -0.227
ENSG00000168610 E035 151.9527954 0.0002532618 7.908133e-04 3.226361e-03 17 42324711 42324825 115 - 2.223 2.140 -0.276
ENSG00000168610 E036 73.2971431 0.0006746137 7.930721e-02 1.584129e-01 17 42324826 42324846 21 - 1.898 1.839 -0.199
ENSG00000168610 E037 128.1342419 0.0002499014 1.147201e-03 4.461972e-03 17 42324963 42325061 99 - 2.153 2.066 -0.292
ENSG00000168610 E038 0.4449813 0.0215036712 3.795000e-01 5.237710e-01 17 42325062 42325157 96 - 0.247 0.106 -1.470
ENSG00000168610 E039 106.8075420 0.0009741255 4.526451e-02 1.006754e-01 17 42326116 42326199 84 - 2.056 1.998 -0.197
ENSG00000168610 E040 0.0000000       17 42326200 42326715 516 -      
ENSG00000168610 E041 0.4417591 0.0932242061 8.156689e-01 8.833289e-01 17 42328951 42329409 459 - 0.141 0.190 0.518
ENSG00000168610 E042 91.7945459 0.0003229379 2.521853e-03 8.828247e-03 17 42329410 42329457 48 - 2.012 1.914 -0.328
ENSG00000168610 E043 0.2998086 0.0295209305 7.918774e-01   17 42329458 42329553 96 - 0.141 0.106 -0.471
ENSG00000168610 E044 113.4000115 0.0028551332 1.311567e-02 3.617618e-02 17 42329554 42329647 94 - 2.097 2.006 -0.303
ENSG00000168610 E045 0.4439371 0.0215566114 4.245978e-02 9.555114e-02 17 42329658 42329746 89 - 0.332 0.000 -12.582
ENSG00000168610 E046 67.5992045 0.0015342847 4.549376e-03 1.467930e-02 17 42329747 42329776 30 - 1.890 1.772 -0.395
ENSG00000168610 E047 1.1061078 0.0122682484 2.007596e-01 3.271457e-01 17 42329777 42329791 15 - 0.141 0.378 1.856
ENSG00000168610 E048 0.4481018 0.0994630240 8.191809e-01 8.858309e-01 17 42330631 42331471 841 - 0.141 0.190 0.515
ENSG00000168610 E049 73.9828323 0.0004244106 2.460521e-02 6.106483e-02 17 42331472 42331531 60 - 1.906 1.827 -0.267
ENSG00000168610 E050 0.0000000       17 42331532 42331538 7 -      
ENSG00000168610 E051 71.5526622 0.0046387349 1.391104e-01 2.468417e-01 17 42333673 42333765 93 - 1.883 1.817 -0.223
ENSG00000168610 E052 108.8984977 0.0019134486 3.191365e-02 7.568974e-02 17 42333891 42334049 159 - 2.069 1.998 -0.238
ENSG00000168610 E053 118.8377550 0.0024177449 1.006863e-01 1.915075e-01 17 42337435 42337586 152 - 2.096 2.044 -0.172
ENSG00000168610 E054 87.7732542 0.0018392826 9.922924e-02 1.893025e-01 17 42337763 42337857 95 - 1.968 1.912 -0.188
ENSG00000168610 E055 83.2141079 0.0023058301 1.950573e-04 9.427270e-04 17 42338731 42338812 82 - 1.999 1.847 -0.511
ENSG00000168610 E056 83.7621916 0.0003285408 3.783543e-09 5.040653e-08 17 42339314 42339409 96 - 2.034 1.822 -0.714
ENSG00000168610 E057 0.2214452 0.0460983550 6.623077e-01   17 42345414 42345558 145 - 0.000 0.106 9.412
ENSG00000168610 E058 85.5271493 0.0033429075 4.843197e-05 2.738484e-04 17 42345559 42345657 99 - 2.026 1.852 -0.585
ENSG00000168610 E059 103.0070388 0.0034317678 1.523958e-05 9.710971e-05 17 42346569 42346713 145 - 2.106 1.931 -0.588
ENSG00000168610 E060 101.3406108 0.0067218497 1.031693e-02 2.954844e-02 17 42348389 42348517 129 - 2.067 1.948 -0.397
ENSG00000168610 E061 32.9721849 0.0233663135 2.185584e-01 3.486845e-01 17 42348518 42348520 3 - 1.572 1.478 -0.324
ENSG00000168610 E062 27.7556727 0.0299444809 1.527574e-01 2.654141e-01 17 42348521 42348539 19 - 1.521 1.391 -0.447
ENSG00000168610 E063 0.0000000       17 42374059 42374206 148 -      
ENSG00000168610 E064 1.6512104 0.0085397219 5.776613e-01 7.028883e-01 17 42386939 42388278 1340 - 0.464 0.377 -0.467
ENSG00000168610 E065 79.5961928 0.0172642806 4.208235e-02 9.487985e-02 17 42388279 42388540 262 - 1.969 1.837 -0.446