ENSG00000168591

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000319511 ENSG00000168591 HEK293_OSMI2_2hA HEK293_TMG_2hB TMUB2 protein_coding protein_coding 25.31422 31.12383 18.21295 1.433793 0.49732 -0.7727261 7.446424 7.967740 5.8889943 0.7945016 0.3202520 -0.4355112 0.29929167 0.25593333 0.32403333 0.06810000 0.30719683 2.582857e-06 FALSE TRUE
ENST00000357984 ENSG00000168591 HEK293_OSMI2_2hA HEK293_TMG_2hB TMUB2 protein_coding protein_coding 25.31422 31.12383 18.21295 1.433793 0.49732 -0.7727261 2.311929 3.261861 2.0141020 0.9673376 0.8340425 -0.6928296 0.08808333 0.10240000 0.10890000 0.00650000 1.00000000 2.582857e-06 FALSE TRUE
ENST00000589785 ENSG00000168591 HEK293_OSMI2_2hA HEK293_TMG_2hB TMUB2 protein_coding protein_coding 25.31422 31.12383 18.21295 1.433793 0.49732 -0.7727261 2.507571 4.761173 0.5573856 1.0477879 0.4194879 -3.0719425 0.09288333 0.15673333 0.03180000 -0.12493333 0.18750738 2.582857e-06 FALSE TRUE
ENST00000592825 ENSG00000168591 HEK293_OSMI2_2hA HEK293_TMG_2hB TMUB2 protein_coding protein_coding 25.31422 31.12383 18.21295 1.433793 0.49732 -0.7727261 1.862001 1.809113 0.9507616 0.5075629 0.2771784 -0.9209850 0.07134167 0.05756667 0.05216667 -0.00540000 0.93609393 2.582857e-06 FALSE TRUE
MSTRG.14437.3 ENSG00000168591 HEK293_OSMI2_2hA HEK293_TMG_2hB TMUB2 protein_coding   25.31422 31.12383 18.21295 1.433793 0.49732 -0.7727261 2.852306 2.406062 2.8942089 0.1651113 0.4987026 0.2654878 0.12357500 0.07720000 0.16033333 0.08313333 0.03286431 2.582857e-06 FALSE TRUE
MSTRG.14437.38 ENSG00000168591 HEK293_OSMI2_2hA HEK293_TMG_2hB TMUB2 protein_coding   25.31422 31.12383 18.21295 1.433793 0.49732 -0.7727261 0.984455 2.699667 0.2577885 0.2719605 0.1392991 -3.3389497 0.03435417 0.08646667 0.01460000 -0.07186667 0.07384252 2.582857e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168591 E001 0.1472490 0.0431383355 2.773453e-01   17 44186895 44186905 11 + 0.155 0.000 -10.208
ENSG00000168591 E002 0.1472490 0.0431383355 2.773453e-01   17 44186906 44186925 20 + 0.155 0.000 -12.439
ENSG00000168591 E003 0.1472490 0.0431383355 2.773453e-01   17 44186926 44186962 37 + 0.155 0.000 -12.439
ENSG00000168591 E004 0.3686942 0.0311818633 6.717760e-01 7.779259e-01 17 44186963 44186969 7 + 0.155 0.096 -0.800
ENSG00000168591 E005 0.3686942 0.0311818633 6.717760e-01 7.779259e-01 17 44186970 44186971 2 + 0.155 0.096 -0.800
ENSG00000168591 E006 2.1904351 0.0494462849 2.357127e-01 3.692179e-01 17 44186972 44186985 14 + 0.604 0.395 -1.021
ENSG00000168591 E007 3.2944560 0.0050411497 3.043328e-02 7.281135e-02 17 44186986 44186989 4 + 0.790 0.473 -1.388
ENSG00000168591 E008 25.4870544 0.0007658245 6.373614e-02 1.329175e-01 17 44186990 44187021 32 + 1.468 1.351 -0.405
ENSG00000168591 E009 31.5188977 0.0006768454 5.167326e-03 1.638329e-02 17 44187022 44187048 27 + 1.584 1.421 -0.560
ENSG00000168591 E010 31.4564565 0.0010838263 2.287821e-03 8.113154e-03 17 44187049 44187049 1 + 1.594 1.413 -0.621
ENSG00000168591 E011 48.5958956 0.0027387949 7.704323e-03 2.303665e-02 17 44187050 44187109 60 + 1.752 1.615 -0.465
ENSG00000168591 E012 2.6851852 0.0056947408 5.176098e-01 6.519532e-01 17 44187206 44187212 7 + 0.603 0.508 -0.441
ENSG00000168591 E013 8.7972214 0.0115067367 9.176059e-01 9.519302e-01 17 44187213 44187222 10 + 0.962 0.961 -0.005
ENSG00000168591 E014 13.0165860 0.0132735465 3.393549e-01 4.832582e-01 17 44187223 44187233 11 + 1.181 1.090 -0.326
ENSG00000168591 E015 24.5719268 0.0028469745 9.633724e-02 1.848801e-01 17 44187234 44187257 24 + 1.455 1.345 -0.380
ENSG00000168591 E016 30.8119464 0.0012201694 8.058151e-02 1.604659e-01 17 44187258 44187261 4 + 1.538 1.437 -0.348
ENSG00000168591 E017 42.8108996 0.0040036178 2.075000e-01 3.354889e-01 17 44187262 44187271 10 + 1.652 1.586 -0.225
ENSG00000168591 E018 45.5682178 0.0026023899 1.920049e-01 3.162691e-01 17 44187272 44187274 3 + 1.676 1.613 -0.216
ENSG00000168591 E019 109.5545599 0.0002783961 4.720161e-01 6.110984e-01 17 44187275 44187400 126 + 2.020 2.007 -0.044
ENSG00000168591 E020 61.8083523 0.0008513777 2.359193e-01 3.694438e-01 17 44187401 44187431 31 + 1.796 1.752 -0.149
ENSG00000168591 E021 83.6008213 0.0027388042 4.727174e-02 1.043216e-01 17 44187432 44187616 185 + 1.948 1.868 -0.268
ENSG00000168591 E022 31.0410134 0.0024532389 2.881216e-04 1.331636e-03 17 44187617 44187653 37 + 1.617 1.392 -0.774
ENSG00000168591 E023 24.0085530 0.0010820626 1.149245e-02 3.233276e-02 17 44187654 44187675 22 + 1.474 1.306 -0.584
ENSG00000168591 E024 59.0254471 0.0006979739 1.256034e-02 3.487467e-02 17 44187676 44187743 68 + 1.816 1.710 -0.359
ENSG00000168591 E025 43.0586477 0.0049227397 8.866453e-03 2.594848e-02 17 44187907 44187931 25 + 1.714 1.564 -0.510
ENSG00000168591 E026 54.4501639 0.0008227593 1.171606e-01 2.158886e-01 17 44187932 44188009 78 + 1.758 1.693 -0.223
ENSG00000168591 E027 7.2076810 0.0174105994 4.449312e-02 9.927552e-02 17 44188851 44188932 82 + 1.037 0.791 -0.932
ENSG00000168591 E028 3.2054094 0.0047961036 8.439269e-02 1.664353e-01 17 44188933 44188934 2 + 0.758 0.507 -1.094
ENSG00000168591 E029 67.7719613 0.0005847709 4.249738e-01 5.679237e-01 17 44188935 44189021 87 + 1.822 1.798 -0.080
ENSG00000168591 E030 138.4552388 0.0005487973 1.002258e-01 1.908256e-01 17 44189022 44189091 70 + 2.140 2.100 -0.135
ENSG00000168591 E031 173.9963580 0.0034789199 3.272711e-03 1.106994e-02 17 44189092 44189206 115 + 2.277 2.178 -0.331
ENSG00000168591 E032 162.6989548 0.0007707611 2.111292e-06 1.633896e-05 17 44189207 44189299 93 + 2.266 2.136 -0.436
ENSG00000168591 E033 120.7095457 0.0021856756 6.478075e-02 1.346852e-01 17 44189300 44189369 70 + 2.093 2.033 -0.200
ENSG00000168591 E034 86.7531467 0.0025378023 4.894406e-01 6.268713e-01 17 44189370 44189410 41 + 1.922 1.903 -0.064
ENSG00000168591 E035 75.4803788 0.0004234174 9.884452e-01 9.968325e-01 17 44189411 44189423 13 + 1.841 1.853 0.039
ENSG00000168591 E036 173.1973744 0.0002005988 5.291026e-01 6.619399e-01 17 44189424 44189588 165 + 2.214 2.208 -0.017
ENSG00000168591 E037 17.6544138 0.0010232483 1.516981e-06 1.211669e-05 17 44189589 44190349 761 + 1.462 1.091 -1.303
ENSG00000168591 E038 399.9222838 0.0002249597 2.275791e-06 1.748570e-05 17 44190501 44190886 386 + 2.500 2.602 0.340
ENSG00000168591 E039 282.4918671 0.0002491819 3.192967e-12 7.217491e-11 17 44190887 44191105 219 + 2.296 2.470 0.583
ENSG00000168591 E040 446.2890638 0.0027179259 1.077131e-16 4.611508e-15 17 44191106 44191929 824 + 2.434 2.688 0.845