ENSG00000168575

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000342228 ENSG00000168575 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC20A2 protein_coding protein_coding 19.19888 17.81347 19.54809 0.2970364 0.8704127 0.1339867 3.2637833 6.7523444 0.000000 0.62920222 0.0000000 -9.4013797 0.18377917 0.380366667 0.0000000 -0.38036667 1.549841e-34 1.549841e-34 FALSE TRUE
ENST00000519463 ENSG00000168575 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC20A2 protein_coding processed_transcript 19.19888 17.81347 19.54809 0.2970364 0.8704127 0.1339867 1.1955012 0.5873444 1.516360 0.19752703 0.2386421 1.3534608 0.06035417 0.033366667 0.0783000 0.04493333 1.259454e-01 1.549841e-34   FALSE
ENST00000520179 ENSG00000168575 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC20A2 protein_coding protein_coding 19.19888 17.81347 19.54809 0.2970364 0.8704127 0.1339867 0.8777944 0.1604971 2.103277 0.05383938 0.4157699 3.6316628 0.04308333 0.009066667 0.1069333 0.09786667 7.196537e-07 1.549841e-34 FALSE TRUE
ENST00000523340 ENSG00000168575 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC20A2 protein_coding processed_transcript 19.19888 17.81347 19.54809 0.2970364 0.8704127 0.1339867 1.9705528 1.2240580 2.480406 0.19516938 0.1743501 1.0129708 0.10023333 0.068433333 0.1266000 0.05816667 1.830137e-02 1.549841e-34   FALSE
MSTRG.31452.1 ENSG00000168575 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC20A2 protein_coding   19.19888 17.81347 19.54809 0.2970364 0.8704127 0.1339867 9.9702452 8.1795056 10.320313 1.02083077 0.1845785 0.3350357 0.51550000 0.457533333 0.5292667 0.07173333 5.770304e-01 1.549841e-34 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168575 E001 0.0000000       8 42416341 42416474 134 -      
ENSG00000168575 E002 227.9595109 0.0056528738 1.301275e-06 1.054639e-05 8 42416475 42416883 409 - 2.214 2.426 0.705
ENSG00000168575 E003 341.4518993 0.0008714964 1.001389e-14 3.293579e-13 8 42416884 42417604 721 - 2.409 2.593 0.610
ENSG00000168575 E004 121.0197093 0.0045876834 3.104843e-02 7.400882e-02 8 42417605 42417802 198 - 2.015 2.117 0.344
ENSG00000168575 E005 148.7120114 0.0002840678 4.956871e-04 2.143542e-03 8 42417803 42417967 165 - 2.098 2.207 0.366
ENSG00000168575 E006 116.5361726 0.0002804798 6.309099e-04 2.646913e-03 8 42428758 42428842 85 - 1.986 2.107 0.403
ENSG00000168575 E007 180.4276716 0.0002654031 1.672209e-02 4.432621e-02 8 42430064 42430249 186 - 2.206 2.276 0.232
ENSG00000168575 E008 292.3544010 0.0012368606 2.433647e-02 6.051042e-02 8 42436989 42437474 486 - 2.420 2.481 0.204
ENSG00000168575 E009 107.4910780 0.0012986447 5.448531e-01 6.752636e-01 8 42437475 42437577 103 - 2.009 2.036 0.092
ENSG00000168575 E010 59.5967841 0.0009162503 3.068702e-01 4.490452e-01 8 42439450 42439466 17 - 1.738 1.792 0.181
ENSG00000168575 E011 147.4021141 0.0003146438 3.085960e-01 4.508762e-01 8 42439467 42439653 187 - 2.176 2.151 -0.083
ENSG00000168575 E012 113.9798246 0.0002475256 7.585225e-03 2.273300e-02 8 42444646 42444762 117 - 2.100 2.018 -0.276
ENSG00000168575 E013 98.3916143 0.0003297412 4.114458e-03 1.346401e-02 8 42459896 42459992 97 - 2.047 1.951 -0.323
ENSG00000168575 E014 0.2934659 0.0288893488 8.637540e-01   8 42459993 42460168 176 - 0.135 0.111 -0.319
ENSG00000168575 E015 77.4159747 0.0052868012 2.096735e-01 3.381719e-01 8 42463005 42463077 73 - 1.923 1.862 -0.206
ENSG00000168575 E016 47.5972037 0.0021574024 8.760126e-01 9.243811e-01 8 42463078 42463090 13 - 1.670 1.683 0.045
ENSG00000168575 E017 0.7761102 0.0802665069 4.375947e-01 5.795273e-01 8 42463216 42463371 156 - 0.135 0.275 1.284
ENSG00000168575 E018 95.9064555 0.0007992711 6.180595e-01 7.357920e-01 8 42465777 42465917 141 - 1.985 1.971 -0.047
ENSG00000168575 E019 5.7090302 0.0041920420 4.035986e-01 5.473666e-01 8 42471067 42471201 135 - 0.877 0.775 -0.399
ENSG00000168575 E020 74.2941925 0.0003540736 2.114887e-02 5.391287e-02 8 42472102 42472156 55 - 1.920 1.831 -0.298
ENSG00000168575 E021 62.6923198 0.0007948773 3.439468e-03 1.155150e-02 8 42472157 42472178 22 - 1.867 1.740 -0.429
ENSG00000168575 E022 85.7492275 0.0007748047 1.097542e-03 4.295461e-03 8 42472179 42472248 70 - 1.998 1.874 -0.415
ENSG00000168575 E023 88.2058868 0.0030575157 1.896373e-02 4.925314e-02 8 42472249 42472305 57 - 1.999 1.897 -0.344
ENSG00000168575 E024 74.3658001 0.0094474057 2.381652e-02 5.943760e-02 8 42472306 42472338 33 - 1.946 1.806 -0.470
ENSG00000168575 E025 168.0390279 0.0071547288 1.070613e-03 4.203266e-03 8 42472339 42472654 316 - 2.305 2.154 -0.504
ENSG00000168575 E026 0.4482035 0.0266409553 5.532546e-02 1.185527e-01 8 42480459 42480513 55 - 0.320 0.000 -13.032
ENSG00000168575 E027 0.1472490 0.0425617847 3.968794e-01   8 42501031 42501186 156 - 0.135 0.000 -11.188
ENSG00000168575 E028 0.5117906 0.2195452370 5.172183e-01 6.516507e-01 8 42501187 42501243 57 - 0.237 0.113 -1.292
ENSG00000168575 E029 0.4482035 0.0266409553 5.532546e-02 1.185527e-01 8 42502284 42502628 345 - 0.320 0.000 -13.032
ENSG00000168575 E030 23.7108663 0.0010334518 2.600362e-05 1.570488e-04 8 42534660 42534870 211 - 1.541 1.253 -1.000
ENSG00000168575 E031 37.1695146 0.0028584733 1.745036e-07 1.692057e-06 8 42534871 42535171 301 - 1.739 1.425 -1.071
ENSG00000168575 E032 11.8560009 0.0014250975 4.645158e-04 2.024178e-03 8 42535172 42535186 15 - 1.274 0.948 -1.178
ENSG00000168575 E033 23.1593461 0.0153348020 1.398809e-04 7.030488e-04 8 42535187 42535335 149 - 1.550 1.212 -1.172
ENSG00000168575 E034 7.7741413 0.1025096697 5.133602e-02 1.115277e-01 8 42536355 42536471 117 - 1.112 0.755 -1.351
ENSG00000168575 E035 2.8379523 0.0059052466 4.260238e-05 2.440401e-04 8 42536472 42536593 122 - 0.856 0.199 -3.405
ENSG00000168575 E036 14.7508683 0.0018460513 2.290003e-05 1.400278e-04 8 42540915 42540979 65 - 1.378 1.014 -1.296
ENSG00000168575 E037 20.2433636 0.0278300673 2.056844e-04 9.883710e-04 8 42540980 42541451 472 - 1.518 1.119 -1.394
ENSG00000168575 E038 3.9136556 0.0040805198 1.827988e-02 4.774277e-02 8 42541452 42541537 86 - 0.856 0.523 -1.405
ENSG00000168575 E039 59.2341919 0.0004391228 2.074548e-05 1.282073e-04 8 42541538 42541711 174 - 1.878 1.691 -0.631
ENSG00000168575 E040 1.6899071 0.0147020360 3.326738e-01 4.763470e-01 8 42541821 42541926 106 - 0.502 0.336 -0.898