ENSG00000168538

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334690 ENSG00000168538 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC11 protein_coding protein_coding 6.384666 2.270513 8.915724 0.06689267 0.04914727 1.968611 4.4798680 0.94411472 7.0640832 0.18093595 0.10662844 2.890309 0.60500833 0.415700000 0.79246667 0.37676667 1.561573e-04 3.101168e-22 FALSE TRUE
ENST00000511955 ENSG00000168538 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC11 protein_coding retained_intron 6.384666 2.270513 8.915724 0.06689267 0.04914727 1.968611 0.3177990 0.13649355 0.2838913 0.05242354 0.02234622 1.004445 0.06183750 0.059900000 0.03186667 -0.02803333 4.766931e-01 3.101168e-22 FALSE TRUE
ENST00000512476 ENSG00000168538 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC11 protein_coding protein_coding 6.384666 2.270513 8.915724 0.06689267 0.04914727 1.968611 0.5004764 1.10822256 0.0000000 0.12724606 0.00000000 -6.805064 0.17421250 0.489800000 0.00000000 -0.48980000 3.101168e-22 3.101168e-22 FALSE TRUE
MSTRG.25797.3 ENSG00000168538 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC11 protein_coding   6.384666 2.270513 8.915724 0.06689267 0.04914727 1.968611 0.6823153 0.01853223 1.0948491 0.01853223 0.04772775 5.275113 0.08897083 0.007733333 0.12273333 0.11500000 5.946364e-06 3.101168e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168538 E001 0.1515154 0.0423920841 1.000000e+00   4 183659267 183659292 26 + 0.062 0.000 -8.133
ENSG00000168538 E002 1.6242331 0.0082932055 7.339198e-02 1.489469e-01 4 183659293 183659309 17 + 0.427 0.000 -13.631
ENSG00000168538 E003 4.5760218 0.0035564363 2.260625e-01 3.576715e-01 4 183659310 183659322 13 + 0.708 0.490 -0.977
ENSG00000168538 E004 9.7618781 0.0019578996 2.379446e-01 3.717427e-01 4 183659323 183659375 53 + 0.979 0.817 -0.615
ENSG00000168538 E005 15.9526568 0.0051477435 1.998417e-02 5.145199e-02 4 183659376 183659447 72 + 1.189 0.901 -1.053
ENSG00000168538 E006 6.1357244 0.0026135602 1.786517e-03 6.556064e-03 4 183660104 183660395 292 + 0.851 0.229 -3.130
ENSG00000168538 E007 33.1009656 0.0008851471 4.709011e-05 2.670423e-04 4 183663847 183664016 170 + 1.498 1.131 -1.281
ENSG00000168538 E008 19.3697066 0.0009877263 2.454529e-05 1.492021e-04 4 183664017 183664029 13 + 1.292 0.769 -1.931
ENSG00000168538 E009 23.3993688 0.0008048715 1.738314e-06 1.370447e-05 4 183664030 183664071 42 + 1.372 0.817 -2.017
ENSG00000168538 E010 0.1451727 0.0426323047 1.000000e+00   4 183666226 183666256 31 + 0.062 0.000 -10.361
ENSG00000168538 E011 33.6617710 0.0006463226 8.740748e-04 3.523510e-03 4 183666257 183666426 170 + 1.495 1.212 -0.985
ENSG00000168538 E012 0.0000000       4 183666893 183666955 63 +      
ENSG00000168538 E013 0.0000000       4 183666956 183666983 28 +      
ENSG00000168538 E014 0.0000000       4 183666984 183667059 76 +      
ENSG00000168538 E015 22.9359960 0.0008483517 4.623960e-02 1.024772e-01 4 183667060 183667130 71 + 1.324 1.131 -0.682
ENSG00000168538 E016 0.0000000       4 183667962 183668002 41 +      
ENSG00000168538 E017 26.0474892 0.0007628730 1.904390e-01 3.143095e-01 4 183668003 183668117 115 + 1.363 1.248 -0.402
ENSG00000168538 E018 23.8390726 0.0008161064 6.726278e-03 2.051177e-02 4 183674713 183674812 100 + 1.352 1.084 -0.947
ENSG00000168538 E019 0.3686942 0.0284048529 2.689828e-01 4.074519e-01 4 183674813 183674870 58 + 0.062 0.230 2.195
ENSG00000168538 E020 20.3325157 0.0009404181 1.585704e-02 4.241656e-02 4 183675164 183675237 74 + 1.285 1.031 -0.907
ENSG00000168538 E021 27.3508237 0.0007171250 3.857654e-02 8.840969e-02 4 183677458 183677554 97 + 1.396 1.212 -0.643
ENSG00000168538 E022 33.4744634 0.0042352003 1.091949e-01 2.043569e-01 4 183679353 183679486 134 + 1.476 1.340 -0.469
ENSG00000168538 E023 30.2649905 0.0007782009 1.951092e-02 5.043577e-02 4 183680120 183680207 88 + 1.446 1.248 -0.691
ENSG00000168538 E024 27.2669067 0.0007375428 8.434617e-01 9.025309e-01 4 183680208 183680267 60 + 1.363 1.379 0.056
ENSG00000168538 E025 31.8731982 0.0006685848 1.051568e-01 1.983299e-01 4 183682732 183682825 94 + 1.456 1.326 -0.450
ENSG00000168538 E026 0.0000000       4 183683849 183683974 126 +      
ENSG00000168538 E027 17.9359877 0.0010137570 3.051291e-03 1.041696e-02 4 183683975 183684006 32 + 1.245 0.901 -1.254
ENSG00000168538 E028 23.2508209 0.0022417726 1.122393e-02 3.170330e-02 4 183684007 183684054 48 + 1.340 1.084 -0.906
ENSG00000168538 E029 25.4931924 0.0018488645 2.100084e-02 5.359177e-02 4 183684145 183684223 79 + 1.372 1.153 -0.769
ENSG00000168538 E030 30.5765229 0.0036035079 4.492795e-02 1.000678e-01 4 183684305 183684359 55 + 1.442 1.265 -0.614
ENSG00000168538 E031 43.9890902 0.0496369385 4.425870e-01 5.841844e-01 4 183684696 183684841 146 + 1.578 1.500 -0.266
ENSG00000168538 E032 28.0050351 0.0096702696 8.208748e-01 8.870752e-01 4 183685084 183685145 62 + 1.377 1.355 -0.075
ENSG00000168538 E033 39.9792676 0.0007114669 4.370946e-01 5.791177e-01 4 183685271 183685403 133 + 1.510 1.562 0.179
ENSG00000168538 E034 38.3588211 0.0029001156 3.692657e-01 5.136819e-01 4 183686618 183686714 97 + 1.518 1.450 -0.234
ENSG00000168538 E035 25.1488099 0.0054961696 1.435421e-01 2.528346e-01 4 183686715 183686748 34 + 1.355 1.213 -0.496
ENSG00000168538 E036 50.6080112 0.0004890031 8.738122e-01 9.228890e-01 4 183691316 183691471 156 + 1.626 1.616 -0.032
ENSG00000168538 E037 53.1827125 0.0004136619 6.344399e-01 7.488970e-01 4 183692960 183693147 188 + 1.652 1.624 -0.095
ENSG00000168538 E038 46.1586354 0.0153705132 6.396605e-01 7.530044e-01 4 183693589 183693737 149 + 1.596 1.559 -0.126
ENSG00000168538 E039 39.8788192 0.0198188627 4.490007e-01 5.902072e-01 4 183693917 183694038 122 + 1.511 1.582 0.244
ENSG00000168538 E040 34.1369406 0.0011228113 1.614554e-02 4.305152e-02 4 183694604 183694723 120 + 1.420 1.586 0.571
ENSG00000168538 E041 25.6378678 0.0007980265 1.604240e-03 5.975000e-03 4 183697503 183697568 66 + 1.278 1.518 0.833
ENSG00000168538 E042 49.0723496 0.0064249203 2.200823e-02 5.569514e-02 4 183697679 183697835 157 + 1.578 1.735 0.533
ENSG00000168538 E043 4.9175578 0.0034037799 3.273614e-01 4.708078e-01 4 183700853 183701659 807 + 0.668 0.817 0.606
ENSG00000168538 E044 0.6060617 0.9347722084 1.000000e+00 1.000000e+00 4 183701660 183701696 37 + 0.209 0.000 -11.279
ENSG00000168538 E045 42.8152020 0.0018687538 1.159196e-02 3.256400e-02 4 183701697 183701808 112 + 1.516 1.677 0.550
ENSG00000168538 E046 40.1413320 0.0005677004 8.209705e-02 1.628369e-01 4 183704979 183705070 92 + 1.504 1.616 0.384
ENSG00000168538 E047 1.6432733 0.1757372488 9.842999e-01 9.942828e-01 4 183706787 183706806 20 + 0.376 0.374 -0.011
ENSG00000168538 E048 49.4397277 0.0004813585 4.253794e-02 9.570202e-02 4 183706807 183706940 134 + 1.590 1.708 0.401
ENSG00000168538 E049 22.4661923 0.0008749868 7.363963e-01 8.268967e-01 4 183708407 183708416 10 + 1.281 1.311 0.104
ENSG00000168538 E050 39.0364627 0.0040547253 1.880134e-02 4.889706e-02 4 183708417 183708535 119 + 1.480 1.644 0.558
ENSG00000168538 E051 29.3219403 0.0120557092 3.175579e-02 7.537951e-02 4 183708536 183708574 39 + 1.351 1.536 0.637
ENSG00000168538 E052 126.8347606 0.0002897015 1.012878e-22 8.738007e-21 4 183712600 183713594 995 + 1.926 2.253 1.094