ENSG00000168517

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307275 ENSG00000168517 HEK293_OSMI2_2hA HEK293_TMG_2hB HEXIM2 protein_coding protein_coding 9.164717 19.43438 4.940915 0.6324951 0.1468437 -1.973586 0.5905104 1.493663 0.29430865 0.3533492 0.01742188 -2.304874 0.07014583 0.07653333 0.05963333 -0.01690000 0.78925684 0.0004295949 FALSE TRUE
ENST00000589230 ENSG00000168517 HEK293_OSMI2_2hA HEK293_TMG_2hB HEXIM2 protein_coding protein_coding 9.164717 19.43438 4.940915 0.6324951 0.1468437 -1.973586 2.9714352 5.642493 1.94085740 0.2424154 0.02879805 -1.534779 0.34695833 0.29013333 0.39383333 0.10370000 0.02202306 0.0004295949 FALSE TRUE
ENST00000591576 ENSG00000168517 HEK293_OSMI2_2hA HEK293_TMG_2hB HEXIM2 protein_coding protein_coding 9.164717 19.43438 4.940915 0.6324951 0.1468437 -1.973586 0.9178728 1.403178 0.06055741 0.3053608 0.06055741 -4.324002 0.09440000 0.07210000 0.01236667 -0.05973333 0.10833950 0.0004295949 FALSE TRUE
ENST00000592695 ENSG00000168517 HEK293_OSMI2_2hA HEK293_TMG_2hB HEXIM2 protein_coding protein_coding 9.164717 19.43438 4.940915 0.6324951 0.1468437 -1.973586 3.2298855 6.946291 1.59629110 0.2530841 0.46038705 -2.114585 0.34000417 0.35766667 0.31840000 -0.03926667 0.83095715 0.0004295949 FALSE TRUE
MSTRG.14469.6 ENSG00000168517 HEK293_OSMI2_2hA HEK293_TMG_2hB HEXIM2 protein_coding   9.164717 19.43438 4.940915 0.6324951 0.1468437 -1.973586 0.4768384 1.292372 0.56544820 0.6646342 0.28482410 -1.178383 0.05579167 0.06566667 0.11790000 0.05223333 0.92656333 0.0004295949 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168517 E001 2.496130 0.0105424512 0.6112520129 0.730380256 17 45160700 45160729 30 + 0.367 0.466 0.538
ENSG00000168517 E002 8.753072 0.0020959538 0.7378193041 0.827885201 17 45160730 45160943 214 + 0.842 0.888 0.177
ENSG00000168517 E003 1.029835 0.0128223652 0.4293531461 0.572089362 17 45161078 45161093 16 + 0.366 0.215 -1.045
ENSG00000168517 E004 7.754659 0.0025917187 0.5385764184 0.669991639 17 45161094 45161248 155 + 0.750 0.841 0.358
ENSG00000168517 E005 3.531049 0.0046618315 0.6281099823 0.743756184 17 45161249 45161400 152 + 0.634 0.552 -0.368
ENSG00000168517 E006 5.195120 0.0031673959 0.0765030350 0.153903754 17 45161875 45161894 20 + 0.881 0.624 -1.044
ENSG00000168517 E007 6.410898 0.0105988849 0.2515233956 0.387773252 17 45161895 45161895 1 + 0.881 0.715 -0.660
ENSG00000168517 E008 17.931167 0.0088341204 0.1842354920 0.306547289 17 45161896 45161916 21 + 1.260 1.126 -0.475
ENSG00000168517 E009 25.736237 0.0117309546 0.4160483650 0.559413430 17 45161917 45161939 23 + 1.358 1.284 -0.258
ENSG00000168517 E010 39.787550 0.0005727428 0.1847648901 0.307177244 17 45161940 45162031 92 + 1.557 1.470 -0.298
ENSG00000168517 E011 46.942054 0.0020308224 0.6899623799 0.791781827 17 45162488 45162635 148 + 1.580 1.555 -0.086
ENSG00000168517 E012 5.467746 0.0099685613 0.0560439958 0.119779412 17 45162747 45162749 3 + 0.918 0.640 -1.111
ENSG00000168517 E013 85.215710 0.0003625175 0.1937241384 0.318461484 17 45162750 45162859 110 + 1.856 1.798 -0.194
ENSG00000168517 E014 366.484155 0.0003398479 0.0004693831 0.002042944 17 45169015 45170040 1026 + 2.388 2.446 0.194