ENSG00000168488

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340394 ENSG00000168488 HEK293_OSMI2_2hA HEK293_TMG_2hB ATXN2L protein_coding protein_coding 79.36699 90.84399 67.3298 4.652426 1.275903 -0.4320905 12.344408 9.422646 15.441855 2.3686178 0.4457851 0.7120456 0.15791667 0.10240000 0.2296000 0.12720000 2.446244e-02 3.068069e-56 FALSE TRUE
ENST00000567024 ENSG00000168488 HEK293_OSMI2_2hA HEK293_TMG_2hB ATXN2L protein_coding protein_coding 79.36699 90.84399 67.3298 4.652426 1.275903 -0.4320905 5.064155 16.106854 0.000000 3.5100458 0.0000000 -10.6543544 0.05697917 0.17860000 0.0000000 -0.17860000 5.604635e-22 3.068069e-56   FALSE
ENST00000568266 ENSG00000168488 HEK293_OSMI2_2hA HEK293_TMG_2hB ATXN2L protein_coding protein_coding 79.36699 90.84399 67.3298 4.652426 1.275903 -0.4320905 2.854299 0.000000 6.058739 0.0000000 0.3737492 9.2452530 0.04079583 0.00000000 0.0902000 0.09020000 4.661620e-51 3.068069e-56 FALSE TRUE
MSTRG.12366.10 ENSG00000168488 HEK293_OSMI2_2hA HEK293_TMG_2hB ATXN2L protein_coding   79.36699 90.84399 67.3298 4.652426 1.275903 -0.4320905 4.246826 5.583140 3.384237 1.0857604 1.3921441 -0.7205711 0.05565000 0.06290000 0.0495000 -0.01340000 7.928043e-01 3.068069e-56 FALSE TRUE
MSTRG.12366.27 ENSG00000168488 HEK293_OSMI2_2hA HEK293_TMG_2hB ATXN2L protein_coding   79.36699 90.84399 67.3298 4.652426 1.275903 -0.4320905 4.955364 5.057437 4.845943 0.6300324 0.2784524 -0.0615049 0.06292917 0.05526667 0.0721000 0.01683333 2.664374e-01 3.068069e-56 TRUE TRUE
MSTRG.12366.28 ENSG00000168488 HEK293_OSMI2_2hA HEK293_TMG_2hB ATXN2L protein_coding   79.36699 90.84399 67.3298 4.652426 1.275903 -0.4320905 20.356624 18.556813 14.332287 3.4820588 0.4155436 -0.3724511 0.25639167 0.20220000 0.2129667 0.01076667 9.056906e-01 3.068069e-56 FALSE TRUE
MSTRG.12366.33 ENSG00000168488 HEK293_OSMI2_2hA HEK293_TMG_2hB ATXN2L protein_coding   79.36699 90.84399 67.3298 4.652426 1.275903 -0.4320905 1.870399 9.086912 0.000000 0.5712063 0.0000000 -9.8292331 0.01995000 0.10030000 0.0000000 -0.10030000 3.068069e-56 3.068069e-56 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168488 E001 11.165505 0.0103858665 1.012758e-02 2.907690e-02 16 28822999 28823034 36 + 1.206 0.937 -0.978
ENSG00000168488 E002 10.538843 0.0016990901 6.813157e-02 1.402665e-01 16 28823035 28823047 13 + 1.140 0.962 -0.650
ENSG00000168488 E003 23.535211 0.0053736607 2.058298e-02 5.271576e-02 16 28823048 28823092 45 + 1.466 1.294 -0.598
ENSG00000168488 E004 17.275721 0.0043432223 2.777325e-02 6.756677e-02 16 28823093 28823094 2 + 1.344 1.163 -0.639
ENSG00000168488 E005 65.410077 0.0016616623 3.132453e-06 2.333597e-05 16 28823095 28823251 157 + 1.922 1.709 -0.716
ENSG00000168488 E006 119.141080 0.0132745069 4.218757e-10 6.697652e-09 16 28823252 28823481 230 + 2.262 1.872 -1.307
ENSG00000168488 E007 115.564494 0.0120897710 3.260809e-10 5.274508e-09 16 28823482 28823558 77 + 2.246 1.864 -1.280
ENSG00000168488 E008 23.194672 0.0007839727 5.394123e-04 2.307763e-03 16 28824138 28824271 134 + 1.498 1.259 -0.830
ENSG00000168488 E009 17.278575 0.0013822811 3.453227e-02 8.077385e-02 16 28824272 28824311 40 + 1.337 1.170 -0.587
ENSG00000168488 E010 28.546701 0.0035910153 1.351172e-01 2.412530e-01 16 28824312 28824450 139 + 1.509 1.412 -0.333
ENSG00000168488 E011 35.655599 0.0022623737 5.110598e-03 1.623141e-02 16 28824451 28824542 92 + 1.639 1.474 -0.566
ENSG00000168488 E012 8.899091 0.0018772501 1.151905e-03 4.477605e-03 16 28824543 28824661 119 + 1.163 0.821 -1.270
ENSG00000168488 E013 108.008584 0.0010096900 2.375321e-16 9.769811e-15 16 28825366 28825370 5 + 2.178 1.882 -0.990
ENSG00000168488 E014 164.353056 0.0005133814 2.982563e-14 9.148924e-13 16 28825371 28825402 32 + 2.320 2.105 -0.720
ENSG00000168488 E015 239.443265 0.0003296590 5.386659e-15 1.844697e-13 16 28825624 28825680 57 + 2.465 2.283 -0.606
ENSG00000168488 E016 2.665493 0.0657490973 2.330404e-01 3.660339e-01 16 28825681 28825769 89 + 0.678 0.470 -0.949
ENSG00000168488 E017 354.533367 0.0009745430 3.379540e-15 1.192927e-13 16 28825770 28825841 72 + 2.635 2.456 -0.595
ENSG00000168488 E018 3.486861 0.0065050268 1.961526e-04 9.474651e-04 16 28825842 28826184 343 + 0.891 0.328 -2.590
ENSG00000168488 E019 605.867055 0.0029820260 2.496823e-13 6.713250e-12 16 28826240 28826390 151 + 2.883 2.679 -0.681
ENSG00000168488 E020 2.906749 0.0053889316 1.325592e-03 5.061256e-03 16 28826391 28826605 215 + 0.823 0.327 -2.328
ENSG00000168488 E021 501.272260 0.0024605421 5.388697e-17 2.391922e-15 16 28826862 28826923 62 + 2.813 2.585 -0.758
ENSG00000168488 E022 474.758690 0.0011041580 6.099094e-18 3.066494e-16 16 28826924 28826986 63 + 2.767 2.581 -0.617
ENSG00000168488 E023 476.276528 0.0011883374 2.030575e-11 4.018872e-10 16 28829401 28829492 92 + 2.745 2.602 -0.477
ENSG00000168488 E024 2.578712 0.0404230781 5.627866e-02 1.202023e-01 16 28829778 28829857 80 + 0.711 0.382 -1.553
ENSG00000168488 E025 249.361102 0.0005558707 2.747848e-11 5.327175e-10 16 28829858 28829868 11 + 2.471 2.313 -0.526
ENSG00000168488 E026 551.463738 0.0004057974 2.203236e-06 1.697907e-05 16 28829869 28830058 190 + 2.770 2.695 -0.249
ENSG00000168488 E027 520.971328 0.0019965262 2.394248e-01 3.734516e-01 16 28830615 28830790 176 + 2.714 2.695 -0.063
ENSG00000168488 E028 3.219218 0.0048284180 4.839725e-05 2.737093e-04 16 28830791 28830802 12 + 0.891 0.266 -3.006
ENSG00000168488 E029 2.775395 0.0055008246 4.086453e-04 1.807617e-03 16 28830803 28830936 134 + 0.823 0.266 -2.743
ENSG00000168488 E030 288.757202 0.0006774155 4.192933e-02 9.459989e-02 16 28830962 28830984 23 + 2.469 2.429 -0.136
ENSG00000168488 E031 442.081107 0.0014563977 3.969627e-02 9.046142e-02 16 28830985 28831072 88 + 2.655 2.615 -0.133
ENSG00000168488 E032 18.028090 0.0079220766 2.869158e-02 6.938920e-02 16 28832187 28832204 18 + 1.373 1.186 -0.657
ENSG00000168488 E033 745.720801 0.0031236682 9.405363e-03 2.729417e-02 16 28832205 28832399 195 + 2.895 2.835 -0.202
ENSG00000168488 E034 437.166492 0.0063407460 1.264623e-01 2.292222e-01 16 28832496 28832567 72 + 2.657 2.609 -0.161
ENSG00000168488 E035 505.551290 0.0050435004 3.036335e-02 7.267892e-02 16 28832817 28832887 71 + 2.731 2.664 -0.223
ENSG00000168488 E036 715.787335 0.0021282153 8.551335e-03 2.516856e-02 16 28833059 28833195 137 + 2.874 2.820 -0.181
ENSG00000168488 E037 714.903232 0.0009187222 2.886318e-02 6.972676e-02 16 28833196 28833354 159 + 2.859 2.827 -0.106
ENSG00000168488 E038 472.344402 0.0007659504 4.892416e-02 1.072474e-01 16 28833439 28833508 70 + 2.678 2.646 -0.105
ENSG00000168488 E039 10.800756 0.0029693973 3.126492e-06 2.329431e-05 16 28833856 28834064 209 + 1.289 0.821 -1.714
ENSG00000168488 E040 663.038445 0.0006855029 6.837627e-01 7.868817e-01 16 28834065 28834211 147 + 2.794 2.812 0.061
ENSG00000168488 E041 3.098944 0.0048802569 7.697674e-01 8.513291e-01 16 28834329 28834342 14 + 0.561 0.612 0.232
ENSG00000168488 E042 441.891536 0.0004988475 1.018687e-01 1.933430e-01 16 28834343 28834415 73 + 2.601 2.644 0.142
ENSG00000168488 E043 259.588517 0.0005089215 1.264954e-04 6.434027e-04 16 28834506 28834522 17 + 2.328 2.434 0.352
ENSG00000168488 E044 612.578245 0.0006129285 1.983941e-06 1.544617e-05 16 28834523 28834693 171 + 2.706 2.806 0.334
ENSG00000168488 E045 8.228957 0.1011972540 4.461347e-01 5.876631e-01 16 28834852 28835057 206 + 1.017 0.900 -0.439
ENSG00000168488 E046 341.692763 0.0002448971 1.563828e-04 7.755363e-04 16 28835058 28835098 41 + 2.460 2.548 0.293
ENSG00000168488 E047 485.120983 0.0011097375 3.135955e-05 1.856902e-04 16 28835099 28835187 89 + 2.602 2.709 0.355
ENSG00000168488 E048 5.306991 0.0030419927 2.860962e-04 1.323333e-03 16 28835188 28835277 90 + 1.018 0.548 -1.895
ENSG00000168488 E049 583.272177 0.0037775180 2.921514e-05 1.743055e-04 16 28835278 28835399 122 + 2.653 2.805 0.506
ENSG00000168488 E050 14.467760 0.0024180850 4.486651e-06 3.228804e-05 16 28835400 28835545 146 + 1.380 0.975 -1.446
ENSG00000168488 E051 67.038620 0.0016112971 4.137667e-02 9.358396e-02 16 28835546 28835548 3 + 1.745 1.852 0.362
ENSG00000168488 E052 254.628496 0.0028461056 8.357406e-08 8.619804e-07 16 28835549 28835554 6 + 2.258 2.458 0.667
ENSG00000168488 E053 381.254705 0.0049299529 3.360081e-06 2.488593e-05 16 28835555 28835594 40 + 2.437 2.633 0.653
ENSG00000168488 E054 418.257865 0.0044338998 2.254747e-07 2.140055e-06 16 28835595 28835668 74 + 2.469 2.676 0.691
ENSG00000168488 E055 329.539998 0.0022576013 1.248893e-11 2.559765e-10 16 28835669 28835758 90 + 2.352 2.576 0.747
ENSG00000168488 E056 408.107527 0.0074096436 2.090599e-06 1.619603e-05 16 28835933 28836122 190 + 2.440 2.673 0.778
ENSG00000168488 E057 122.482234 0.0023157399 1.949860e-03 7.071522e-03 16 28836123 28836176 54 + 1.984 2.121 0.459
ENSG00000168488 E058 157.801271 0.0024352362 8.230286e-03 2.436832e-02 16 28836177 28836325 149 + 2.110 2.221 0.374
ENSG00000168488 E059 202.683824 0.0002237887 3.898179e-09 5.179899e-08 16 28836326 28836445 120 + 2.179 2.346 0.558
ENSG00000168488 E060 103.677000 0.0002852178 6.398315e-07 5.540206e-06 16 28836446 28836448 3 + 1.872 2.066 0.652
ENSG00000168488 E061 176.863893 0.0014326879 3.702593e-06 2.716463e-05 16 28836449 28836485 37 + 2.125 2.289 0.551
ENSG00000168488 E062 82.193255 0.0003401822 1.291275e-03 4.946581e-03 16 28836486 28836490 5 + 1.811 1.951 0.473
ENSG00000168488 E063 187.047106 0.0001947844 1.223526e-05 7.964862e-05 16 28836491 28836597 107 + 2.171 2.300 0.430
ENSG00000168488 E064 250.550339 0.0016094092 2.205556e-03 7.859969e-03 16 28836598 28836727 130 + 2.320 2.422 0.341
ENSG00000168488 E065 297.097835 0.0053918876 7.694610e-06 5.246998e-05 16 28836728 28836747 20 + 2.326 2.527 0.669
ENSG00000168488 E066 259.337480 0.0058591739 4.066847e-05 2.339808e-04 16 28836748 28836750 3 + 2.273 2.467 0.646
ENSG00000168488 E067 542.401987 0.0034527750 9.388970e-12 1.965862e-10 16 28836751 28836849 99 + 2.560 2.798 0.789
ENSG00000168488 E068 778.038994 0.0038519507 9.006575e-22 6.978603e-20 16 28836850 28837237 388 + 2.646 2.977 1.101