ENSG00000168438

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307731 ENSG00000168438 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC40 protein_coding protein_coding 12.30123 3.059756 20.68357 0.5046668 0.291026 2.752986 7.7862172 2.2133744 11.884426 0.2181185 2.5400813 2.419463 0.68792083 0.7494667 0.5743667 -0.17510000 6.191741e-01 9.613996e-14 FALSE TRUE
ENST00000368930 ENSG00000168438 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC40 protein_coding protein_coding 12.30123 3.059756 20.68357 0.5046668 0.291026 2.752986 2.0767866 0.0000000 4.610206 0.0000000 0.4512551 8.851813 0.09836667 0.0000000 0.2228667 0.22286667 9.613996e-14 9.613996e-14 FALSE TRUE
ENST00000368932 ENSG00000168438 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC40 protein_coding protein_coding 12.30123 3.059756 20.68357 0.5046668 0.291026 2.752986 1.9182715 0.2766739 3.493133 0.2766739 2.1127988 3.611163 0.13926250 0.1054000 0.1690333 0.06363333 6.878623e-01 9.613996e-14 FALSE TRUE
ENST00000445340 ENSG00000168438 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC40 protein_coding processed_transcript 12.30123 3.059756 20.68357 0.5046668 0.291026 2.752986 0.2216111 0.5182960 0.000000 0.5182960 0.0000000 -5.723275 0.04946667 0.1274667 0.0000000 -0.12746667 4.519290e-01 9.613996e-14   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168438 E001 0.4396707 0.0286530390 1.000000e+00 1.000000e+00 6 110180141 110180180 40 + 0.137 0.000 -8.733
ENSG00000168438 E002 4.1244718 0.0902668870 1.499271e-01 2.615858e-01 6 110180384 110180420 37 + 0.637 0.267 -1.974
ENSG00000168438 E003 5.7819998 0.1029339848 8.479087e-01 9.055703e-01 6 110180421 110180426 6 + 0.716 0.648 -0.286
ENSG00000168438 E004 93.6145980 0.0067313730 4.671258e-02 1.033157e-01 6 110180427 110180633 207 + 1.848 1.712 -0.461
ENSG00000168438 E005 74.7382676 0.0015715271 3.323493e-02 7.826494e-02 6 110193182 110193268 87 + 1.752 1.615 -0.467
ENSG00000168438 E006 0.0000000       6 110198975 110199037 63 +      
ENSG00000168438 E007 49.5235002 0.0004556959 5.615955e-01 6.893613e-01 6 110201558 110201604 47 + 1.568 1.525 -0.147
ENSG00000168438 E008 67.0544553 0.0003609897 4.683803e-01 6.077952e-01 6 110201605 110201687 83 + 1.695 1.649 -0.157
ENSG00000168438 E009 82.9540750 0.0003214247 1.732853e-01 2.924733e-01 6 110207506 110207589 84 + 1.790 1.711 -0.266
ENSG00000168438 E010 111.9270099 0.0003058462 1.550275e-01 2.684523e-01 6 110209084 110209223 140 + 1.917 1.846 -0.237
ENSG00000168438 E011 0.4762024 0.2220622790 3.368940e-01 4.807511e-01 6 110209224 110209316 93 + 0.096 0.269 1.790
ENSG00000168438 E012 94.8266937 0.0030600636 8.093812e-02 1.610034e-01 6 110210707 110210803 97 + 1.851 1.745 -0.355
ENSG00000168438 E013 9.9611552 0.0246034499 9.248190e-01 9.566561e-01 6 110210804 110212132 1329 + 0.913 0.893 -0.078
ENSG00000168438 E014 101.6925079 0.0017381400 1.953066e-02 5.047921e-02 6 110212133 110212272 140 + 1.884 1.752 -0.445
ENSG00000168438 E015 84.0518569 0.0011754358 2.311466e-02 5.798621e-02 6 110213086 110213160 75 + 1.803 1.665 -0.466
ENSG00000168438 E016 61.9400947 0.0021017213 2.011965e-01 3.276830e-01 6 110215286 110215331 46 + 1.667 1.577 -0.308
ENSG00000168438 E017 91.9362666 0.0003508477 3.529820e-01 4.972299e-01 6 110217702 110217803 102 + 1.829 1.778 -0.172
ENSG00000168438 E018 105.3900154 0.0002646810 5.858525e-01 7.094877e-01 6 110219364 110219479 116 + 1.885 1.857 -0.094
ENSG00000168438 E019 120.9371940 0.0013100238 9.290768e-01 9.594014e-01 6 110219736 110219869 134 + 1.939 1.941 0.009
ENSG00000168438 E020 0.1515154 0.0422119899 7.952053e-01   6 110224296 110224432 137 + 0.051 0.000 -8.596
ENSG00000168438 E021 75.5691175 0.0018374402 9.469126e-01 9.706712e-01 6 110226167 110226243 77 + 1.737 1.740 0.010
ENSG00000168438 E022 89.8635766 0.0003176162 4.006265e-01 5.443060e-01 6 110228832 110228976 145 + 1.805 1.847 0.140
ENSG00000168438 E023 254.9952767 0.0004946210 6.206304e-08 6.564856e-07 6 110229954 110231451 1498 + 2.236 2.387 0.505
ENSG00000168438 E024 64.7460056 0.0005687093 7.069952e-16 2.725643e-14 6 110231452 110232232 781 + 1.585 1.993 1.380
ENSG00000168438 E025 0.0000000       6 110253885 110254275 391 +