ENSG00000168411

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361070 ENSG00000168411 HEK293_OSMI2_2hA HEK293_TMG_2hB RFWD3 protein_coding protein_coding 40.3155 28.08915 49.79631 5.268723 0.9785853 0.8258019 26.504068 25.35392504 27.479834 4.97892003 1.8495664 0.1161202 0.6911583 0.899766667 0.5509667 -0.3488000 3.778071e-13 1.571486e-28 FALSE TRUE
ENST00000571750 ENSG00000168411 HEK293_OSMI2_2hA HEK293_TMG_2hB RFWD3 protein_coding protein_coding 40.3155 28.08915 49.79631 5.268723 0.9785853 0.8258019 5.070143 1.01964305 8.841208 0.26341978 0.8536341 3.1037301 0.1157417 0.038500000 0.1783667 0.1398667 4.508390e-05 1.571486e-28 FALSE TRUE
MSTRG.13032.2 ENSG00000168411 HEK293_OSMI2_2hA HEK293_TMG_2hB RFWD3 protein_coding   40.3155 28.08915 49.79631 5.268723 0.9785853 0.8258019 4.968914 0.04268978 9.087826 0.04268978 0.9455380 7.4318549 0.1031708 0.001366667 0.1826000 0.1812333 2.409871e-22 1.571486e-28 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168411 E001 424.8934489 0.0091033289 1.153486e-16 4.921721e-15 16 74621399 74621831 433 - 2.373 2.836 1.542
ENSG00000168411 E002 1170.8352804 0.0048948690 1.092602e-13 3.087563e-12 16 74621832 74622872 1041 - 2.925 3.206 0.935
ENSG00000168411 E003 837.7841108 0.0016091281 3.130676e-05 1.854414e-04 16 74622873 74623428 556 - 2.857 3.000 0.475
ENSG00000168411 E004 319.1758639 0.0030874807 1.114387e-01 2.076604e-01 16 74623429 74623538 110 - 2.457 2.563 0.355
ENSG00000168411 E005 217.5522522 0.0029368790 6.757633e-01 7.809314e-01 16 74623539 74623597 59 - 2.308 2.380 0.240
ENSG00000168411 E006 624.5009734 0.0002094629 4.232040e-01 5.663057e-01 16 74623598 74624071 474 - 2.766 2.838 0.241
ENSG00000168411 E007 355.7128021 0.0003284299 5.722143e-01 6.983597e-01 16 74626343 74626554 212 - 2.533 2.582 0.166
ENSG00000168411 E008 177.7789245 0.0008945067 4.744359e-01 6.132590e-01 16 74628452 74628507 56 - 2.217 2.299 0.271
ENSG00000168411 E009 262.7402884 0.0005519132 5.016916e-01 6.378362e-01 16 74628508 74628666 159 - 2.389 2.466 0.256
ENSG00000168411 E010 278.0575892 0.0017777020 4.811822e-02 1.058371e-01 16 74630781 74630957 177 - 2.445 2.446 0.002
ENSG00000168411 E011 261.0403558 0.0017482804 6.761491e-04 2.811863e-03 16 74632523 74632673 151 - 2.435 2.388 -0.157
ENSG00000168411 E012 1.1436862 0.0801166251 4.154695e-01 5.588453e-01 16 74632674 74632733 60 - 0.242 0.431 1.186
ENSG00000168411 E013 326.1577247 0.0009924909 1.607342e-09 2.293313e-08 16 74636346 74636577 232 - 2.549 2.457 -0.308
ENSG00000168411 E014 132.9034291 0.0007246392 2.210672e-08 2.557433e-07 16 74637856 74637875 20 - 2.175 2.045 -0.433
ENSG00000168411 E015 201.5257110 0.0002263766 4.972264e-09 6.493731e-08 16 74637876 74637970 95 - 2.341 2.249 -0.306
ENSG00000168411 E016 1.8133244 0.0076806278 8.051640e-02 1.603599e-01 16 74643979 74644361 383 - 0.543 0.267 -1.548
ENSG00000168411 E017 220.3102076 0.0018408395 6.695555e-04 2.787012e-03 16 74644362 74644453 92 - 2.364 2.311 -0.176
ENSG00000168411 E018 189.4806883 0.0040425743 3.923583e-02 8.961692e-02 16 74644541 74644619 79 - 2.290 2.258 -0.107
ENSG00000168411 E019 248.7382721 0.0010268249 2.084058e-08 2.421605e-07 16 74644620 74644735 116 - 2.433 2.337 -0.323
ENSG00000168411 E020 194.5697350 0.0006932525 1.230288e-11 2.525182e-10 16 74649132 74649193 62 - 2.341 2.205 -0.456
ENSG00000168411 E021 130.6837356 0.0002391010 3.244287e-10 5.249576e-09 16 74649194 74649202 9 - 2.173 2.031 -0.475
ENSG00000168411 E022 2.3993138 0.0061632674 2.038302e-03 7.345587e-03 16 74649203 74649243 41 - 0.675 0.154 -3.132
ENSG00000168411 E023 280.1916197 0.0024949197 6.246416e-10 9.630247e-09 16 74651920 74652122 203 - 2.502 2.354 -0.492
ENSG00000168411 E024 1.3683431 0.0097968482 5.563125e-02 1.190625e-01 16 74660600 74660779 180 - 0.476 0.154 -2.225
ENSG00000168411 E025 2.8461784 0.0055161749 4.157284e-01 5.590928e-01 16 74660780 74660931 152 - 0.510 0.684 0.773
ENSG00000168411 E026 194.3957121 0.0047606856 4.679591e-06 3.353096e-05 16 74660932 74660997 66 - 2.342 2.194 -0.495
ENSG00000168411 E027 229.4846328 0.0065681899 2.658102e-06 2.013472e-05 16 74660998 74661081 84 - 2.421 2.250 -0.571
ENSG00000168411 E028 155.3551827 0.0071655094 9.313730e-05 4.897735e-04 16 74661082 74661100 19 - 2.245 2.100 -0.484
ENSG00000168411 E029 333.7822934 0.0038212655 2.402659e-05 1.463684e-04 16 74661101 74661451 351 - 2.560 2.459 -0.337
ENSG00000168411 E030 1.9283081 0.0074550773 8.426210e-03 2.485396e-02 16 74661956 74662040 85 - 0.601 0.154 -2.811
ENSG00000168411 E031 3.1526219 0.0168818491 6.929527e-02 1.421940e-01 16 74664335 74664623 289 - 0.697 0.432 -1.224
ENSG00000168411 E032 59.7595454 0.0031435572 7.375523e-04 3.034313e-03 16 74664624 74664689 66 - 1.827 1.698 -0.436
ENSG00000168411 E033 52.1295878 0.0007385039 2.493902e-06 1.900569e-05 16 74664690 74664745 56 - 1.789 1.604 -0.627
ENSG00000168411 E034 2.2338532 0.2483691641 1.482570e-01 2.593071e-01 16 74665233 74665280 48 - 0.625 0.265 -1.933
ENSG00000168411 E035 0.4439371 0.0215605350 1.745478e-01 2.941090e-01 16 74666305 74666785 481 - 0.242 0.000 -10.270
ENSG00000168411 E036 74.0237406 0.0009447687 9.031027e-09 1.122491e-07 16 74666786 74666841 56 - 1.942 1.741 -0.680
ENSG00000168411 E037 44.2485688 0.0004894660 1.842365e-07 1.777775e-06 16 74666842 74666883 42 - 1.732 1.500 -0.790