ENSG00000168395

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313552 ENSG00000168395 HEK293_OSMI2_2hA HEK293_TMG_2hB ING5 protein_coding protein_coding 33.92086 36.40683 30.52295 0.9501502 0.8542827 -0.2542383 11.150768 12.453316 11.9118286 0.6800056 0.2815139 -0.06408237 0.32991250 0.34306667 0.39120000 0.04813333 0.53651093 0.04874204 FALSE TRUE
ENST00000406941 ENSG00000168395 HEK293_OSMI2_2hA HEK293_TMG_2hB ING5 protein_coding protein_coding 33.92086 36.40683 30.52295 0.9501502 0.8542827 -0.2542383 5.104368 6.384762 4.5410367 0.8918787 0.3573615 -0.49069554 0.15013333 0.17486667 0.14943333 -0.02543333 0.74938573 0.04874204 FALSE TRUE
ENST00000482774 ENSG00000168395 HEK293_OSMI2_2hA HEK293_TMG_2hB ING5 protein_coding processed_transcript 33.92086 36.40683 30.52295 0.9501502 0.8542827 -0.2542383 1.462645 2.468278 0.4604735 0.3258834 0.4604735 -2.39715285 0.04225000 0.06833333 0.01503333 -0.05330000 0.11972291 0.04874204 FALSE TRUE
ENST00000489509 ENSG00000168395 HEK293_OSMI2_2hA HEK293_TMG_2hB ING5 protein_coding retained_intron 33.92086 36.40683 30.52295 0.9501502 0.8542827 -0.2542383 1.895259 2.219200 1.3886907 0.4634432 0.2531790 -0.67244903 0.05515833 0.06040000 0.04506667 -0.01533333 0.63373630 0.04874204 FALSE TRUE
ENST00000492488 ENSG00000168395 HEK293_OSMI2_2hA HEK293_TMG_2hB ING5 protein_coding retained_intron 33.92086 36.40683 30.52295 0.9501502 0.8542827 -0.2542383 2.637052 4.072297 1.4677580 0.6470118 0.3193717 -1.46597093 0.07697917 0.11286667 0.04773333 -0.06513333 0.04874204 0.04874204 FALSE TRUE
ENST00000493261 ENSG00000168395 HEK293_OSMI2_2hA HEK293_TMG_2hB ING5 protein_coding retained_intron 33.92086 36.40683 30.52295 0.9501502 0.8542827 -0.2542383 3.747634 1.228659 5.0891890 0.7610094 0.7711023 2.04148840 0.11507500 0.03273333 0.16693333 0.13420000 0.22408130 0.04874204 FALSE TRUE
MSTRG.20200.1 ENSG00000168395 HEK293_OSMI2_2hA HEK293_TMG_2hB ING5 protein_coding   33.92086 36.40683 30.52295 0.9501502 0.8542827 -0.2542383 4.603885 5.493417 3.2840686 0.2859916 0.3373540 -0.74045692 0.13439583 0.15146667 0.10780000 -0.04366667 0.20368723 0.04874204 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168395 E001 17.7446092 0.0010452884 3.815070e-01 5.257996e-01 2 241687056 241687084 29 + 1.300 1.229 -0.249
ENSG00000168395 E002 80.4169934 0.0016846525 1.092484e-01 2.044449e-01 2 241687085 241687820 736 + 1.851 1.922 0.239
ENSG00000168395 E003 27.7402045 0.0106438445 1.216744e-01 2.223205e-01 2 241687821 241687908 88 + 1.368 1.502 0.463
ENSG00000168395 E004 56.3802610 0.0054644657 1.275707e-01 2.307637e-01 2 241687909 241688062 154 + 1.693 1.786 0.313
ENSG00000168395 E005 9.0560913 0.0043630373 5.701298e-03 1.782029e-02 2 241688312 241688332 21 + 0.766 1.093 1.237
ENSG00000168395 E006 131.1659222 0.0002567225 1.728965e-03 6.374125e-03 2 241689838 241690413 576 + 2.047 2.147 0.335
ENSG00000168395 E007 70.5225503 0.0047847146 4.638274e-02 1.027302e-01 2 241690414 241690653 240 + 1.776 1.886 0.370
ENSG00000168395 E008 30.5092526 0.0037959364 1.399412e-01 2.479442e-01 2 241694115 241694289 175 + 1.426 1.531 0.360
ENSG00000168395 E009 15.9464155 0.0014862289 2.758898e-01 4.152849e-01 2 241700065 241701961 1897 + 1.275 1.183 -0.326
ENSG00000168395 E010 8.3715786 0.0020462664 1.428189e-02 3.886827e-02 2 241701962 241702034 73 + 1.098 0.826 -1.016
ENSG00000168395 E011 9.5787370 0.0017334528 1.306634e-01 2.350810e-01 2 241702035 241702038 4 + 1.098 0.939 -0.583
ENSG00000168395 E012 10.0257947 0.0017500701 9.900447e-02 1.889536e-01 2 241702039 241702041 3 + 1.123 0.953 -0.621
ENSG00000168395 E013 14.5447393 0.0013824714 1.480134e-01 2.589718e-01 2 241702042 241702045 4 + 1.258 1.131 -0.449
ENSG00000168395 E014 68.1268119 0.0004662361 8.239288e-03 2.439148e-02 2 241702046 241702060 15 + 1.892 1.778 -0.384
ENSG00000168395 E015 87.7989907 0.0003275405 4.698878e-02 1.038096e-01 2 241702061 241702064 4 + 1.980 1.904 -0.254
ENSG00000168395 E016 126.3982385 0.0002763915 6.477332e-01 7.593651e-01 2 241702065 241702102 38 + 2.101 2.087 -0.049
ENSG00000168395 E017 197.0791672 0.0002155730 9.553238e-01 9.759612e-01 2 241704653 241704724 72 + 2.285 2.284 -0.005
ENSG00000168395 E018 0.7686241 0.1212986639 1.338939e-01 2.395621e-01 2 241709086 241709215 130 + 0.395 0.109 -2.380
ENSG00000168395 E019 283.9308981 0.0001943163 1.786516e-01 2.994618e-01 2 241709216 241709382 167 + 2.424 2.453 0.096
ENSG00000168395 E020 188.3267495 0.0001990649 1.265173e-01 2.292996e-01 2 241711377 241711488 112 + 2.240 2.280 0.134
ENSG00000168395 E021 5.0678387 0.0096046503 9.897859e-03 2.851329e-02 2 241711489 241711584 96 + 0.963 0.615 -1.389
ENSG00000168395 E022 3.1577195 0.0302322472 1.180805e-03 4.576232e-03 2 241711585 241711623 39 + 0.865 0.329 -2.480
ENSG00000168395 E023 169.6712975 0.0002204558 1.910623e-02 4.957159e-02 2 241711978 241712071 94 + 2.178 2.244 0.219
ENSG00000168395 E024 18.1123971 0.0125555929 2.070403e-03 7.442585e-03 2 241712072 241712380 309 + 1.057 1.373 1.120
ENSG00000168395 E025 18.3736386 0.0009785980 7.375599e-02 1.495366e-01 2 241719483 241719612 130 + 1.180 1.327 0.518
ENSG00000168395 E026 25.6809427 0.0036028451 7.784665e-03 2.323918e-02 2 241719613 241719919 307 + 1.284 1.486 0.700
ENSG00000168395 E027 62.9701032 0.0006488222 8.155702e-07 6.903195e-06 2 241719976 241720740 765 + 1.637 1.874 0.799
ENSG00000168395 E028 66.4698607 0.0007906965 1.658018e-08 1.962430e-07 2 241720741 241721430 690 + 1.630 1.900 0.913
ENSG00000168395 E029 21.9927914 0.0018151368 8.550860e-08 8.793956e-07 2 241721431 241721805 375 + 1.013 1.470 1.617
ENSG00000168395 E030 183.8555924 0.0010150831 7.753636e-01 8.552864e-01 2 241722939 241723074 136 + 2.261 2.254 -0.025
ENSG00000168395 E031 161.8921771 0.0003074962 5.495698e-01 6.792827e-01 2 241723210 241723271 62 + 2.191 2.208 0.058
ENSG00000168395 E032 29.5438873 0.0160128045 1.911112e-01 3.151340e-01 2 241723791 241724038 248 + 1.401 1.525 0.428
ENSG00000168395 E033 655.5397066 0.0023721825 3.275422e-01 4.710117e-01 2 241724989 241726447 1459 + 2.819 2.796 -0.076
ENSG00000168395 E034 119.5163784 0.0026972794 2.190623e-07 2.083996e-06 2 241726448 241726783 336 + 2.185 1.975 -0.703
ENSG00000168395 E035 303.8302838 0.0002105088 2.556703e-08 2.918532e-07 2 241726784 241727742 959 + 2.538 2.423 -0.381
ENSG00000168395 E036 55.8699299 0.0004603555 3.834581e-03 1.267756e-02 2 241727743 241727767 25 + 1.820 1.684 -0.460
ENSG00000168395 E037 138.3008671 0.0002973077 3.650755e-05 2.124089e-04 2 241727768 241727945 178 + 2.201 2.076 -0.421
ENSG00000168395 E038 273.8424928 0.0024743339 2.607560e-02 6.409769e-02 2 241727946 241728499 554 + 2.465 2.398 -0.223
ENSG00000168395 E039 353.2217431 0.0043471536 1.125701e-02 3.177866e-02 2 241728500 241729478 979 + 2.480 2.570 0.302