ENSG00000168393

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000305784 ENSG00000168393 HEK293_OSMI2_2hA HEK293_TMG_2hB DTYMK protein_coding protein_coding 161.932 312.5806 89.07202 14.7905 2.058825 -1.811068 126.90108 252.53895 63.750162 13.193358 2.0184472 -1.985836 0.76500833 0.8075333 0.7154333 -0.0921 3.351819e-08 3.351819e-08 FALSE  
ENST00000400770 ENSG00000168393 HEK293_OSMI2_2hA HEK293_TMG_2hB DTYMK protein_coding nonsense_mediated_decay 161.932 312.5806 89.07202 14.7905 2.058825 -1.811068 13.43231 27.80465 9.712207 1.124764 0.2956369 -1.516489 0.08161667 0.0893000 0.1093000 0.0200 2.458616e-01 3.351819e-08 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168393 E001 0.1515154 4.239107e-02 1.034665e-01   2 241675530 241675606 77 - 0.220 0.000 -10.587
ENSG00000168393 E002 3.9027743 1.559050e-02 3.827139e-02 8.785762e-02 2 241675607 241675746 140 - 0.220 0.654 2.409
ENSG00000168393 E003 16.6300705 3.965632e-02 4.377164e-01 5.796205e-01 2 241675747 241675753 7 - 1.210 1.120 -0.321
ENSG00000168393 E004 76.2536406 3.886755e-03 4.776753e-03 1.530816e-02 2 241675754 241675757 4 - 1.890 1.734 -0.526
ENSG00000168393 E005 154.0921067 2.515493e-04 4.401177e-01 5.818207e-01 2 241675758 241675773 16 - 2.086 2.058 -0.093
ENSG00000168393 E006 183.9671946 2.689209e-04 5.039831e-01 6.398992e-01 2 241675774 241675785 12 - 2.120 2.144 0.079
ENSG00000168393 E007 282.0090602 1.347226e-03 5.502684e-02 1.180443e-01 2 241675786 241675857 72 - 2.270 2.335 0.218
ENSG00000168393 E008 2261.1384258 1.315606e-03 4.142466e-03 1.354203e-02 2 241675858 241676119 262 - 3.181 3.236 0.184
ENSG00000168393 E009 861.6603353 1.117371e-03 8.779236e-02 1.717774e-01 2 241676120 241676122 3 - 2.775 2.815 0.134
ENSG00000168393 E010 1543.1999140 1.052129e-03 1.994805e-01 3.255935e-01 2 241676123 241676177 55 - 3.039 3.066 0.089
ENSG00000168393 E011 1441.2253290 6.910481e-04 2.241157e-01 3.553301e-01 2 241676178 241676237 60 - 3.012 3.035 0.076
ENSG00000168393 E012 21.7856679 6.174532e-03 6.102674e-01 7.296191e-01 2 241676965 241677121 157 - 1.275 1.227 -0.168
ENSG00000168393 E013 14.0130665 4.781179e-03 8.260615e-02 1.636173e-01 2 241677122 241677175 54 - 1.209 1.026 -0.662
ENSG00000168393 E014 2251.5372418 7.093972e-05 4.494501e-02 1.000987e-01 2 241678452 241678577 126 - 3.205 3.226 0.069
ENSG00000168393 E015 1661.8019932 1.867199e-04 6.297116e-02 1.316613e-01 2 241678578 241678649 72 - 3.070 3.095 0.083
ENSG00000168393 E016 1499.4096904 3.942934e-04 1.253980e-02 3.482713e-02 2 241680229 241680319 91 - 3.013 3.053 0.130
ENSG00000168393 E017 40.1646335 5.642644e-04 7.361128e-12 1.566023e-10 2 241681919 241682154 236 - 1.795 1.385 -1.402
ENSG00000168393 E018 35.3295270 1.600146e-03 4.609779e-10 7.263047e-09 2 241682155 241682333 179 - 1.742 1.336 -1.389
ENSG00000168393 E019 33.5643756 4.829828e-03 1.813425e-09 2.559970e-08 2 241682799 241682915 117 - 1.731 1.301 -1.476
ENSG00000168393 E020 7.4019258 2.236039e-03 1.988968e-02 5.125261e-02 2 241684716 241684749 34 - 1.038 0.740 -1.142
ENSG00000168393 E021 134.4979527 4.012022e-04 1.291460e-25 1.501922e-23 2 241685116 241685768 653 - 2.279 1.917 -1.210
ENSG00000168393 E022 1142.1474003 1.492078e-03 9.080692e-02 1.764095e-01 2 241685769 241685806 38 - 2.957 2.923 -0.111
ENSG00000168393 E023 1344.0101104 9.326997e-04 1.914169e-02 4.964659e-02 2 241685807 241685873 67 - 3.032 2.993 -0.131
ENSG00000168393 E024 734.2989759 1.883186e-03 3.471866e-03 1.164400e-02 2 241685874 241685877 4 - 2.796 2.724 -0.240
ENSG00000168393 E025 6.2625111 2.719583e-03 7.636751e-06 5.210731e-05 2 241686362 241686653 292 - 1.153 0.590 -2.194
ENSG00000168393 E026 1131.7444961 2.795093e-03 1.451001e-01 2.549767e-01 2 241686654 241686959 306 - 2.954 2.920 -0.115
ENSG00000168393 E027 10.4621850 1.639317e-03 3.301140e-02 7.782658e-02 2 241686960 241688711 1752 - 1.132 0.888 -0.898
ENSG00000168393 E028 0.0000000       2 241688712 241688880 169 -      
ENSG00000168393 E029 0.0000000       2 241688881 241688886 6 -      
ENSG00000168393 E030 0.0000000       2 241688887 241689194 308 -      
ENSG00000168393 E031 0.2214452 3.813398e-02 1.000000e+00   2 241689195 241689869 675 - 0.000 0.065 9.058
ENSG00000168393 E032 0.0000000       2 241689948 241689986 39 -      
ENSG00000168393 E033 0.2214452 3.813398e-02 1.000000e+00   2 241689987 241690167 181 - 0.000 0.065 9.058