ENSG00000168389

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372811 ENSG00000168389 HEK293_OSMI2_2hA HEK293_TMG_2hB MFSD2A protein_coding protein_coding 5.901198 9.17114 5.523052 0.6246253 0.3040857 -0.7305979 4.4761392 7.3304536 3.253269 0.27940318 0.3127393 -1.169551 0.7656917 0.80363333 0.5943333 -0.2093000 0.0869484495 0.0002416495 FALSE TRUE
ENST00000434861 ENSG00000168389 HEK293_OSMI2_2hA HEK293_TMG_2hB MFSD2A protein_coding protein_coding 5.901198 9.17114 5.523052 0.6246253 0.3040857 -0.7305979 0.2923946 0.2394221 1.179119 0.08896491 0.3410406 2.253232 0.0504375 0.02503333 0.2090000 0.1839667 0.0002416495 0.0002416495 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168389 E001 1.2846917 0.0449052187 0.8668247137 0.918284234 1 39955112 39955144 33 + 0.292 0.325 0.213
ENSG00000168389 E002 1.2846917 0.0449052187 0.8668247137 0.918284234 1 39955145 39955145 1 + 0.292 0.325 0.214
ENSG00000168389 E003 1.2846917 0.0449052187 0.8668247137 0.918284234 1 39955146 39955149 4 + 0.292 0.325 0.214
ENSG00000168389 E004 2.8387889 0.0054369485 0.7467438100 0.834429686 1 39955150 39955157 8 + 0.589 0.535 -0.245
ENSG00000168389 E005 28.3114701 0.0007456180 0.0133817648 0.036805633 1 39955158 39955379 222 + 1.533 1.367 -0.570
ENSG00000168389 E006 12.4701467 0.0043472960 0.8794714451 0.926607123 1 39955380 39955385 6 + 1.097 1.081 -0.060
ENSG00000168389 E007 40.3986658 0.0018244751 0.8142854354 0.882330015 1 39957087 39957221 135 + 1.573 1.559 -0.051
ENSG00000168389 E008 0.0000000       1 39957821 39957960 140 +      
ENSG00000168389 E009 0.0000000       1 39958662 39958700 39 +      
ENSG00000168389 E010 45.3906071 0.0005224789 0.2538795477 0.390509554 1 39958701 39958825 125 + 1.659 1.596 -0.215
ENSG00000168389 E011 8.4506043 0.0033384625 0.1879432989 0.311129945 1 39964211 39965210 1000 + 1.044 0.894 -0.559
ENSG00000168389 E012 60.5694052 0.0052083543 0.0030786260 0.010497038 1 39965211 39965334 124 + 1.849 1.684 -0.556
ENSG00000168389 E013 52.1403448 0.0005116824 0.0161749792 0.043108778 1 39965471 39965549 79 + 1.757 1.635 -0.412
ENSG00000168389 E014 63.0437888 0.0022648808 0.0067427642 0.020555096 1 39965857 39966014 158 + 1.846 1.712 -0.453
ENSG00000168389 E015 37.7814665 0.0023511626 0.3283779197 0.471857857 1 39966601 39966661 61 + 1.579 1.517 -0.214
ENSG00000168389 E016 30.4748083 0.0007137144 0.5239838345 0.657615873 1 39966662 39966691 30 + 1.414 1.457 0.147
ENSG00000168389 E017 50.1478300 0.0083642655 0.4855008074 0.623380470 1 39966811 39966932 122 + 1.621 1.669 0.165
ENSG00000168389 E018 49.4859262 0.0005640508 0.7701038415 0.851552603 1 39967086 39967169 84 + 1.640 1.655 0.050
ENSG00000168389 E019 1.2533568 0.0108647759 0.8627061955 0.915460150 1 39967483 39967618 136 + 0.292 0.323 0.204
ENSG00000168389 E020 0.9535482 0.0321106509 0.5696398150 0.696172952 1 39967619 39967627 9 + 0.170 0.276 0.886
ENSG00000168389 E021 48.7259330 0.0139307918 0.2512653719 0.387463745 1 39967628 39967711 84 + 1.584 1.672 0.298
ENSG00000168389 E022 4.5738491 0.0036127987 0.0773742131 0.155264718 1 39967712 39967803 92 + 0.859 0.612 -1.011
ENSG00000168389 E023 59.1604848 0.0005037285 0.1714858573 0.290136740 1 39967804 39967916 113 + 1.681 1.748 0.226
ENSG00000168389 E024 4.7555390 0.0091308583 0.3363731559 0.480210436 1 39967917 39968333 417 + 0.798 0.658 -0.573
ENSG00000168389 E025 70.1350579 0.0004673175 0.0325880777 0.076978012 1 39968334 39968477 144 + 1.730 1.828 0.328
ENSG00000168389 E026 71.4168658 0.0004463338 0.0020127207 0.007265422 1 39968569 39968745 177 + 1.702 1.844 0.480
ENSG00000168389 E027 89.9515907 0.0011775738 0.0003407095 0.001543175 1 39969505 39969968 464 + 1.795 1.949 0.517