ENSG00000168300

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000519554 ENSG00000168300 HEK293_OSMI2_2hA HEK293_TMG_2hB PCMTD1 protein_coding protein_coding 3.944326 0.9999694 6.505792 0.07691457 0.4481392 2.689629 0.37756082 0.05103403 0.7919301 0.02688567 0.17945067 3.715791 0.08473333 0.05110000 0.1207000 0.06960000 4.182285e-01 8.994104e-06 FALSE FALSE
ENST00000519559 ENSG00000168300 HEK293_OSMI2_2hA HEK293_TMG_2hB PCMTD1 protein_coding processed_transcript 3.944326 0.9999694 6.505792 0.07691457 0.4481392 2.689629 0.61466940 0.00000000 1.2793460 0.00000000 0.13932223 7.010496 0.10813750 0.00000000 0.1979667 0.19796667 8.994104e-06 8.994104e-06 FALSE TRUE
ENST00000519975 ENSG00000168300 HEK293_OSMI2_2hA HEK293_TMG_2hB PCMTD1 protein_coding retained_intron 3.944326 0.9999694 6.505792 0.07691457 0.4481392 2.689629 0.38627356 0.03479030 0.6972104 0.01799789 0.14127431 3.980881 0.07023750 0.03233333 0.1052667 0.07293333 2.091131e-01 8.994104e-06 FALSE TRUE
ENST00000521344 ENSG00000168300 HEK293_OSMI2_2hA HEK293_TMG_2hB PCMTD1 protein_coding protein_coding 3.944326 0.9999694 6.505792 0.07691457 0.4481392 2.689629 0.08075887 0.08177918 0.1165896 0.01371113 0.01819032 0.463920 0.03619167 0.08190000 0.0183000 -0.06360000 2.900193e-02 8.994104e-06 FALSE TRUE
ENST00000522514 ENSG00000168300 HEK293_OSMI2_2hA HEK293_TMG_2hB PCMTD1 protein_coding protein_coding 3.944326 0.9999694 6.505792 0.07691457 0.4481392 2.689629 1.92491406 0.49899791 2.4398722 0.08802064 0.65954161 2.266975 0.52267500 0.51916667 0.3905333 -0.12863333 7.662391e-01 8.994104e-06 FALSE TRUE
ENST00000544451 ENSG00000168300 HEK293_OSMI2_2hA HEK293_TMG_2hB PCMTD1 protein_coding protein_coding 3.944326 0.9999694 6.505792 0.07691457 0.4481392 2.689629 0.23706198 0.25172943 0.6635050 0.13173017 0.66350502 1.363613 0.10135417 0.23363333 0.0903000 -0.14333333 4.135228e-01 8.994104e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168300 E001 0.1515154 0.0431002028 1.000000e+00   8 51817575 51817579 5 - 0.060 0.000 -7.009
ENSG00000168300 E002 0.1515154 0.0431002028 1.000000e+00   8 51817580 51817582 3 - 0.060 0.000 -8.782
ENSG00000168300 E003 134.9118804 0.0004495376 1.782376e-10 3.011914e-09 8 51817583 51820146 2564 - 1.997 2.168 0.576
ENSG00000168300 E004 20.9139824 0.0017895804 7.649450e-01 8.478568e-01 8 51820147 51820360 214 - 1.249 1.275 0.090
ENSG00000168300 E005 22.1717409 0.0012707672 3.349516e-01 4.786933e-01 8 51820361 51820494 134 - 1.294 1.204 -0.319
ENSG00000168300 E006 28.0386718 0.0007601898 4.441334e-01 5.857111e-01 8 51820495 51820718 224 - 1.385 1.322 -0.221
ENSG00000168300 E007 6.4455479 0.0058177870 1.458304e-01 2.559941e-01 8 51826929 51827361 433 - 0.831 0.586 -1.018
ENSG00000168300 E008 18.4940999 0.0030539824 9.261541e-03 2.693746e-02 8 51831444 51831567 124 - 1.246 0.947 -1.081
ENSG00000168300 E009 18.9991245 0.0009551343 1.982797e-03 7.173183e-03 8 51833518 51833689 172 - 1.264 0.911 -1.282
ENSG00000168300 E010 9.9606270 0.0054539529 1.659845e-03 6.153433e-03 8 51839447 51839638 192 - 1.021 0.497 -2.148
ENSG00000168300 E011 9.0918947 0.0066464553 4.252044e-03 1.384751e-02 8 51844809 51845660 852 - 0.982 0.497 -2.007
ENSG00000168300 E012 15.1088198 0.0202588057 1.960266e-01 3.212513e-01 8 51845661 51845763 103 - 1.148 0.979 -0.617
ENSG00000168300 E013 3.9522757 0.0041100083 1.903123e-03 6.924157e-03 8 51848945 51850086 1142 - 0.488 0.947 1.918
ENSG00000168300 E014 0.8513531 0.0153787590 2.281690e-01 3.602462e-01 8 51860486 51860844 359 - 0.160 0.386 1.684
ENSG00000168300 E015 8.8106938 0.0020194075 7.361561e-01 8.267191e-01 8 51860845 51860860 16 - 0.917 0.871 -0.178
ENSG00000168300 E016 23.5568941 0.0046264580 3.546999e-01 4.990222e-01 8 51860861 51861246 386 - 1.314 1.223 -0.319
ENSG00000168300 E017 0.0000000       8 51870248 51870390 143 -      
ENSG00000168300 E018 6.5953668 0.0068602100 1.148107e-02 3.230871e-02 8 51898930 51899186 257 - 0.859 0.385 -2.126