ENSG00000168280

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000435030 ENSG00000168280 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF5C protein_coding protein_coding 2.898555 1.687068 4.909552 0.03471984 0.3266427 1.535482 1.07617492 0.2082774 2.707302 0.1055288 0.1781859 3.637941 0.30012917 0.12103333 0.5541000 0.43306667 0.01118595 0.01118595 FALSE TRUE
ENST00000464066 ENSG00000168280 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF5C protein_coding processed_transcript 2.898555 1.687068 4.909552 0.03471984 0.3266427 1.535482 1.05494003 0.4944046 1.850115 0.1069334 0.2127129 1.882738 0.34311667 0.29110000 0.3760333 0.08493333 0.61951009 0.01118595 FALSE TRUE
ENST00000677465 ENSG00000168280 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF5C protein_coding processed_transcript 2.898555 1.687068 4.909552 0.03471984 0.3266427 1.535482 0.10478505 0.1275866 0.000000 0.1275866 0.0000000 -3.782268 0.04876250 0.07853333 0.0000000 -0.07853333 0.61298156 0.01118595 FALSE FALSE
ENST00000678184 ENSG00000168280 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF5C protein_coding retained_intron 2.898555 1.687068 4.909552 0.03471984 0.3266427 1.535482 0.04507718 0.1148656 0.000000 0.1148656 0.0000000 -3.642304 0.02257917 0.06786667 0.0000000 -0.06786667 0.54528483 0.01118595 FALSE TRUE
ENST00000679129 ENSG00000168280 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF5C protein_coding protein_coding 2.898555 1.687068 4.909552 0.03471984 0.3266427 1.535482 0.15778115 0.3823540 0.000000 0.1918108 0.0000000 -5.294084 0.08059583 0.22686667 0.0000000 -0.22686667 0.08586976 0.01118595 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168280 E001 13.7683505 0.0013559358 1.792768e-02 4.698093e-02 2 148875227 148875743 517 + 1.168 0.920 -0.905
ENSG00000168280 E002 12.7269480 0.0013960787 1.281965e-03 4.916856e-03 2 148922137 148922227 91 + 1.152 0.770 -1.433
ENSG00000168280 E003 0.0000000       2 148927042 148927123 82 +      
ENSG00000168280 E004 15.3820475 0.0012652604 9.910487e-03 2.854273e-02 2 148929281 148929354 74 + 1.211 0.951 -0.945
ENSG00000168280 E005 0.1482932 0.0412956728 1.352954e-01   2 148929355 148932049 2695 + 0.000 0.207 13.901
ENSG00000168280 E006 0.0000000       2 148934141 148937283 3143 +      
ENSG00000168280 E007 18.3556155 0.0081706796 2.748476e-01 4.140661e-01 2 148937284 148937388 105 + 1.251 1.160 -0.325
ENSG00000168280 E008 14.3210027 0.0012800633 1.984167e-03 7.177393e-03 2 148941610 148941658 49 + 1.192 0.852 -1.256
ENSG00000168280 E009 15.1029882 0.0015295045 5.865449e-02 1.243264e-01 2 148941935 148941990 56 + 1.188 1.007 -0.653
ENSG00000168280 E010 18.4798637 0.0009492718 4.515687e-02 1.004808e-01 2 148942673 148942760 88 + 1.272 1.100 -0.610
ENSG00000168280 E011 19.2753303 0.0012509007 2.346212e-02 5.870783e-02 2 148946899 148947023 125 + 1.295 1.100 -0.693
ENSG00000168280 E012 0.0000000       2 148947297 148947438 142 +      
ENSG00000168280 E013 0.0000000       2 148947900 148947960 61 +      
ENSG00000168280 E014 13.8406953 0.0017596651 3.277168e-02 7.734997e-02 2 148949839 148949874 36 + 1.168 0.951 -0.790
ENSG00000168280 E015 16.4643818 0.0012140290 6.577477e-01 7.670518e-01 2 148949875 148949943 69 + 1.197 1.177 -0.072
ENSG00000168280 E016 30.5927773 0.0007031535 2.202868e-01 3.507655e-01 2 148950314 148950462 149 + 1.461 1.394 -0.232
ENSG00000168280 E017 0.1515154 0.0420066690 1.000000e+00   2 148952498 148952558 61 + 0.070 0.000 -12.677
ENSG00000168280 E018 0.0000000       2 148955759 148955793 35 +      
ENSG00000168280 E019 0.0000000       2 148955794 148955925 132 +      
ENSG00000168280 E020 0.0000000       2 148955926 148955999 74 +      
ENSG00000168280 E021 32.6232176 0.0009437891 9.863376e-02 1.884112e-01 2 148961971 148962119 149 + 1.492 1.395 -0.335
ENSG00000168280 E022 0.0000000       2 148967890 148968007 118 +      
ENSG00000168280 E023 30.0071963 0.0178667840 4.149378e-01 5.583416e-01 2 148973336 148973511 176 + 1.445 1.387 -0.199
ENSG00000168280 E024 0.0000000       2 148978197 148978296 100 +      
ENSG00000168280 E025 0.0000000       2 148978375 148978444 70 +      
ENSG00000168280 E026 0.0000000       2 148978445 148978550 106 +      
ENSG00000168280 E027 0.0000000       2 148978551 148978741 191 +      
ENSG00000168280 E028 11.9876765 0.0140855819 7.406400e-02 1.500294e-01 2 148978922 148978929 8 + 1.101 0.888 -0.787
ENSG00000168280 E029 18.7351318 0.0064131120 1.392482e-01 2.470238e-01 2 148978930 148978990 61 + 1.268 1.141 -0.450
ENSG00000168280 E030 34.0942976 0.0006364930 7.096869e-02 1.449497e-01 2 148981355 148981561 207 + 1.511 1.405 -0.363
ENSG00000168280 E031 0.4741261 0.0224383029 6.711886e-01 7.774762e-01 2 148981562 148982916 1355 + 0.129 0.207 0.815
ENSG00000168280 E032 0.3666179 0.0260363398 3.767331e-01 5.210586e-01 2 148983281 148983619 339 + 0.069 0.207 1.817
ENSG00000168280 E033 26.8488133 0.0007615956 9.485435e-01 9.717541e-01 2 148983620 148983766 147 + 1.379 1.405 0.092
ENSG00000168280 E034 0.1482932 0.0412956728 1.352954e-01   2 148984723 148988791 4069 + 0.000 0.207 13.901
ENSG00000168280 E035 0.1472490 0.0430925723 1.000000e+00   2 148988792 148991009 2218 + 0.069 0.000 -12.670
ENSG00000168280 E036 26.9503532 0.0009535101 3.175976e-02 7.538705e-02 2 148991010 148991198 189 + 1.423 1.272 -0.528
ENSG00000168280 E037 0.0000000       2 148991199 148991318 120 +      
ENSG00000168280 E038 0.5869198 0.1909747656 3.840899e-01 5.282794e-01 2 148991319 148994420 3102 + 0.229 0.000 -14.097
ENSG00000168280 E039 25.5053970 0.0009034180 7.127467e-02 1.454423e-01 2 148994421 148994538 118 + 1.397 1.272 -0.436
ENSG00000168280 E040 18.4150136 0.0315072436 6.672492e-01 7.745525e-01 2 148997264 148997340 77 + 1.238 1.212 -0.092
ENSG00000168280 E041 0.8877700 0.0665049758 4.520374e-04 1.974844e-03 2 148997341 148998134 794 + 0.000 0.607 15.945
ENSG00000168280 E042 0.6663248 0.0843416575 2.048190e-03 7.375190e-03 2 148998135 148998399 265 + 0.000 0.534 15.559
ENSG00000168280 E043 8.3157154 0.0492345197 3.414805e-01 4.853730e-01 2 148998400 148998402 3 + 0.945 0.814 -0.503
ENSG00000168280 E044 22.8233362 0.0099591598 6.206657e-01 7.377680e-01 2 148998403 148998509 107 + 1.325 1.300 -0.088
ENSG00000168280 E045 0.7845438 0.1793889951 4.186146e-01 5.618631e-01 2 148998510 148998865 356 + 0.183 0.345 1.213
ENSG00000168280 E046 5.1722067 0.0073126020 2.079784e-04 9.980464e-04 2 148998897 148999934 1038 + 0.535 1.056 2.095
ENSG00000168280 E047 4.5747941 0.0035165306 2.174015e-03 7.762315e-03 2 148999935 149000422 488 + 0.535 0.980 1.814
ENSG00000168280 E048 22.0899474 0.0008901134 4.243474e-01 5.673282e-01 2 149000423 149000524 102 + 1.318 1.272 -0.161
ENSG00000168280 E049 18.5705782 0.0011014106 8.837840e-01 9.296876e-01 2 149000722 149000782 61 + 1.234 1.242 0.030
ENSG00000168280 E050 0.0000000       2 149005070 149005392 323 +      
ENSG00000168280 E051 15.1495806 0.0012332645 5.332989e-01 6.655095e-01 2 149005393 149005464 72 + 1.130 1.211 0.288
ENSG00000168280 E052 0.0000000       2 149006007 149006074 68 +      
ENSG00000168280 E053 0.0000000       2 149006075 149006110 36 +      
ENSG00000168280 E054 0.0000000       2 149006111 149006164 54 +      
ENSG00000168280 E055 0.2955422 0.0298948704 3.798987e-01   2 149006893 149007763 871 + 0.069 0.207 1.812
ENSG00000168280 E056 0.0000000       2 149007764 149007962 199 +      
ENSG00000168280 E057 21.8672018 0.0017230583 6.185293e-01 7.361339e-01 2 149007963 149008067 105 + 1.307 1.286 -0.073
ENSG00000168280 E058 0.4428904 0.5572125225 8.434638e-02 1.663714e-01 2 149008068 149008471 404 + 0.000 0.361 13.839
ENSG00000168280 E059 0.4428904 0.5572125225 8.434638e-02 1.663714e-01 2 149008472 149008661 190 + 0.000 0.361 13.839
ENSG00000168280 E060 0.1472490 0.0430925723 1.000000e+00   2 149008662 149009011 350 + 0.069 0.000 -12.670
ENSG00000168280 E061 0.1817044 0.0391268232 1.346797e-01   2 149009012 149010134 1123 + 0.000 0.207 13.919
ENSG00000168280 E062 28.1993618 0.0009158619 6.909334e-01 7.924839e-01 2 149010135 149010351 217 + 1.394 1.445 0.176
ENSG00000168280 E063 0.7728905 0.0153787590 8.877964e-01 9.322777e-01 2 149010352 149011569 1218 + 0.229 0.207 -0.185
ENSG00000168280 E064 18.7154409 0.0117015854 4.673569e-01 6.068638e-01 2 149011570 149011683 114 + 1.252 1.195 -0.202
ENSG00000168280 E065 0.1817044 0.0391268232 1.346797e-01   2 149020176 149020382 207 + 0.000 0.207 13.919
ENSG00000168280 E066 13.3963151 0.0013535650 5.974214e-01 7.191766e-01 2 149023078 149023145 68 + 1.113 1.079 -0.125
ENSG00000168280 E067 272.7047615 0.0015879557 9.064675e-15 3.001180e-13 2 149023146 149026759 3614 + 2.319 2.518 0.666