ENSG00000168246

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393792 ENSG00000168246 HEK293_OSMI2_2hA HEK293_TMG_2hB UBTD2 protein_coding protein_coding 20.71431 10.97387 35.83371 1.55716 0.5732378 1.706333 16.216396 10.90890460 26.0923325 1.50232475 1.3152807 1.257351 0.83614167 0.995233333 0.72736667 -0.26786667 7.753378e-12 1.047884e-28 FALSE TRUE
MSTRG.27301.1 ENSG00000168246 HEK293_OSMI2_2hA HEK293_TMG_2hB UBTD2 protein_coding   20.71431 10.97387 35.83371 1.55716 0.5732378 1.706333 2.000984 0.00000000 5.9147845 0.00000000 0.4455812 9.210619 0.06210417 0.000000000 0.16476667 0.16476667 1.047884e-28 1.047884e-28 FALSE FALSE
MSTRG.27301.3 ENSG00000168246 HEK293_OSMI2_2hA HEK293_TMG_2hB UBTD2 protein_coding   20.71431 10.97387 35.83371 1.55716 0.5732378 1.706333 1.357056 0.06496998 2.9004522 0.06496998 0.2895893 5.278787 0.04827500 0.004766667 0.08120000 0.07643333 2.966688e-05 1.047884e-28 FALSE TRUE
MSTRG.27301.4 ENSG00000168246 HEK293_OSMI2_2hA HEK293_TMG_2hB UBTD2 protein_coding   20.71431 10.97387 35.83371 1.55716 0.5732378 1.706333 1.139875 0.00000000 0.9261446 0.00000000 0.9261446 6.548660 0.05347917 0.000000000 0.02666667 0.02666667 1.000000e+00 1.047884e-28 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168246 E001 1.617799 0.0091320969 1.981937e-01 3.239481e-01 5 172208268 172208297 30 - 0.301 0.561 1.399
ENSG00000168246 E002 891.925585 0.0034638025 1.314419e-08 1.585159e-07 5 172209646 172211561 1916 - 2.864 3.021 0.521
ENSG00000168246 E003 236.451580 0.0001987121 1.499908e-02 4.048572e-02 5 172211562 172211840 279 - 2.345 2.345 -0.001
ENSG00000168246 E004 171.799457 0.0004858555 6.293358e-02 1.316001e-01 5 172211841 172211966 126 - 2.205 2.207 0.007
ENSG00000168246 E005 266.092268 0.0002655412 4.586640e-03 1.478292e-02 5 172211967 172212227 261 - 2.398 2.392 -0.022
ENSG00000168246 E006 240.684125 0.0001894322 2.221930e-09 3.087187e-08 5 172234122 172234358 237 - 2.378 2.290 -0.294
ENSG00000168246 E007 1.779913 0.0079570812 2.813356e-01 4.212297e-01 5 172283592 172283595 4 - 0.478 0.313 -0.922
ENSG00000168246 E008 98.467105 0.0029816680 8.455584e-07 7.135028e-06 5 172283596 172283787 192 - 2.014 1.833 -0.609
ENSG00000168246 E009 7.097579 0.0022719083 3.239573e-04 1.476691e-03 5 172284001 172284051 51 - 0.983 0.493 -2.027