ENSG00000168234

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000317571 ENSG00000168234 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC39C protein_coding protein_coding 6.676925 9.790463 5.998562 0.730593 0.8600988 -0.7058301 1.973038 1.446355 2.545252 0.2148306 0.08248316 0.8111038 0.3174792 0.1461333 0.4430667 0.29693333 0.0002170494 0.0002170494 FALSE TRUE
ENST00000577185 ENSG00000168234 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC39C protein_coding protein_coding 6.676925 9.790463 5.998562 0.730593 0.8600988 -0.7058301 3.213764 6.314187 1.943074 0.4426963 1.18592485 -1.6951333 0.4578292 0.6456667 0.2784667 -0.36720000 0.4434634709 0.0002170494 FALSE FALSE
ENST00000584250 ENSG00000168234 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC39C protein_coding protein_coding 6.676925 9.790463 5.998562 0.730593 0.8600988 -0.7058301 1.145104 1.755709 1.217098 0.1586744 0.35263476 -0.5249971 0.1705542 0.1796667 0.2251000 0.04543333 0.9505493561 0.0002170494 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168234 E001 0.0000000       18 23992773 23993038 266 +      
ENSG00000168234 E002 5.4445681 0.0048696581 5.867979e-01 7.102755e-01 18 24014420 24014753 334 + 0.770 0.836 0.261
ENSG00000168234 E003 10.1066999 0.0349387235 5.681473e-01 6.948468e-01 18 24014754 24014912 159 + 1.093 1.004 -0.325
ENSG00000168234 E004 28.2552194 0.0395797185 2.231291e-01 3.541274e-01 18 24014913 24015038 126 + 1.399 1.515 0.400
ENSG00000168234 E005 1.6061710 0.1742057482 6.188035e-01 7.363537e-01 18 24016634 24016740 107 + 0.362 0.467 0.573
ENSG00000168234 E006 70.3386587 0.0015072988 9.451385e-19 5.240083e-17 18 24019860 24020103 244 + 1.600 1.991 1.324
ENSG00000168234 E007 45.0602364 0.0165139765 4.810443e-08 5.208161e-07 18 24020104 24020288 185 + 1.383 1.805 1.440
ENSG00000168234 E008 2.5692711 0.0082529627 4.279590e-01 5.707796e-01 18 24022541 24022762 222 + 0.470 0.594 0.584
ENSG00000168234 E009 9.5407739 0.0129043488 2.982708e-01 4.397154e-01 18 24064140 24064188 49 + 1.093 0.973 -0.439
ENSG00000168234 E010 17.0215445 0.0130478607 3.303010e-01 4.738988e-01 18 24066012 24066140 129 + 1.305 1.203 -0.359
ENSG00000168234 E011 19.5185892 0.0121855793 6.501148e-02 1.350538e-01 18 24069157 24069271 115 + 1.394 1.214 -0.630
ENSG00000168234 E012 33.9377889 0.0006541233 7.809711e-05 4.189750e-04 18 24080585 24080939 355 + 1.656 1.421 -0.805
ENSG00000168234 E013 22.2046032 0.0008575910 1.296464e-05 8.387213e-05 18 24082913 24083081 169 + 1.513 1.194 -1.111
ENSG00000168234 E014 0.5911836 0.0929380029 8.995608e-02 1.750707e-01 18 24113353 24113665 313 + 0.000 0.297 10.450
ENSG00000168234 E015 0.3289534 0.0281240075 1.000000e+00   18 24114273 24114339 67 + 0.122 0.122 -0.002
ENSG00000168234 E016 0.3289534 0.0281240075 1.000000e+00   18 24114340 24114355 16 + 0.122 0.122 -0.002
ENSG00000168234 E017 0.3289534 0.0281240075 1.000000e+00   18 24114356 24114370 15 + 0.122 0.122 -0.002
ENSG00000168234 E018 18.7358096 0.0011851653 5.033591e-03 1.602363e-02 18 24114554 24114647 94 + 1.400 1.176 -0.786
ENSG00000168234 E019 0.4439371 0.0215739188 8.745399e-02 1.712796e-01 18 24114648 24115032 385 + 0.296 0.000 -11.278
ENSG00000168234 E020 21.9596886 0.0022697483 1.537068e-01 2.667017e-01 18 24118125 24118232 108 + 1.416 1.305 -0.386
ENSG00000168234 E021 0.0000000       18 24123596 24123626 31 +      
ENSG00000168234 E022 0.3332198 0.0292316947 1.000000e+00   18 24123627 24123833 207 + 0.122 0.122 -0.002
ENSG00000168234 E023 26.0313264 0.0008455248 6.196024e-01 7.369619e-01 18 24123834 24123943 110 + 1.458 1.421 -0.128
ENSG00000168234 E024 27.8024403 0.0007369730 3.928903e-01 5.367788e-01 18 24125427 24125550 124 + 1.495 1.436 -0.203
ENSG00000168234 E025 0.0000000       18 24125551 24125662 112 +      
ENSG00000168234 E026 24.0470290 0.0047821666 8.642999e-01 9.165199e-01 18 24128886 24128983 98 + 1.394 1.399 0.017
ENSG00000168234 E027 23.2805332 0.0232581542 7.714242e-01 8.524498e-01 18 24130313 24130417 105 + 1.405 1.364 -0.144
ENSG00000168234 E028 14.5715959 0.0017494969 9.600630e-01 9.789089e-01 18 24131882 24131920 39 + 1.195 1.185 -0.035
ENSG00000168234 E029 156.6546269 0.0248440136 5.037520e-02 1.098327e-01 18 24132485 24135610 3126 + 2.258 2.141 -0.390