ENSG00000168214

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000348160 ENSG00000168214 HEK293_OSMI2_2hA HEK293_TMG_2hB RBPJ protein_coding protein_coding 11.35034 5.679242 16.4453 0.9632933 0.3207106 1.532244 1.93061551 0.0000000 4.0046850 0.0000000 0.5216214 8.6491430 0.137508333 0.00000000 0.24470000 0.24470000 3.784790e-15 3.78479e-15 FALSE TRUE
ENST00000355476 ENSG00000168214 HEK293_OSMI2_2hA HEK293_TMG_2hB RBPJ protein_coding protein_coding 11.35034 5.679242 16.4453 0.9632933 0.3207106 1.532244 5.62141329 3.5086441 6.7407653 0.4309350 0.1978373 0.9400315 0.541212500 0.62776667 0.41006667 -0.21770000 3.421419e-03 3.78479e-15 FALSE TRUE
ENST00000505727 ENSG00000168214 HEK293_OSMI2_2hA HEK293_TMG_2hB RBPJ protein_coding retained_intron 11.35034 5.679242 16.4453 0.9632933 0.3207106 1.532244 0.25302054 0.8992233 0.0000000 0.4967659 0.0000000 -6.5065627 0.047991667 0.15063333 0.00000000 -0.15063333 6.440501e-02 3.78479e-15 FALSE TRUE
ENST00000509158 ENSG00000168214 HEK293_OSMI2_2hA HEK293_TMG_2hB RBPJ protein_coding protein_coding 11.35034 5.679242 16.4453 0.9632933 0.3207106 1.532244 0.18352647 0.4817053 0.1827495 0.1569363 0.1827495 -1.3510670 0.025379167 0.08593333 0.01070000 -0.07523333 8.797945e-02 3.78479e-15 FALSE TRUE
ENST00000514380 ENSG00000168214 HEK293_OSMI2_2hA HEK293_TMG_2hB RBPJ protein_coding retained_intron 11.35034 5.679242 16.4453 0.9632933 0.3207106 1.532244 0.47868846 0.0000000 0.9486670 0.0000000 0.4794649 6.5829578 0.026979167 0.00000000 0.05716667 0.05716667 3.266637e-01 3.78479e-15 FALSE TRUE
ENST00000514807 ENSG00000168214 HEK293_OSMI2_2hA HEK293_TMG_2hB RBPJ protein_coding protein_coding 11.35034 5.679242 16.4453 0.9632933 0.3207106 1.532244 0.41161084 0.0000000 0.9233215 0.0000000 0.9233215 6.5443022 0.021525000 0.00000000 0.05406667 0.05406667 1.000000e+00 3.78479e-15   FALSE
ENST00000680140 ENSG00000168214 HEK293_OSMI2_2hA HEK293_TMG_2hB RBPJ protein_coding protein_coding 11.35034 5.679242 16.4453 0.9632933 0.3207106 1.532244 0.04194266 0.3355413 0.0000000 0.1685780 0.0000000 -5.1107861 0.006954167 0.05563333 0.00000000 -0.05563333 2.548604e-02 3.78479e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168214 E001 0.0000000       4 26163455 26163457 3 +      
ENSG00000168214 E002 0.0000000       4 26163458 26163529 72 +      
ENSG00000168214 E003 0.0000000       4 26163530 26163614 85 +      
ENSG00000168214 E004 0.0000000       4 26263617 26263714 98 +      
ENSG00000168214 E005 0.1451727 0.0442943772 1.000000e+00   4 26319636 26319661 26 + 0.067 0.000 -16.550
ENSG00000168214 E006 0.1451727 0.0442943772 1.000000e+00   4 26319662 26319709 48 + 0.067 0.000 -18.413
ENSG00000168214 E007 0.1472490 0.0451211385 1.000000e+00   4 26319710 26319770 61 + 0.067 0.000 -18.407
ENSG00000168214 E008 0.5900403 0.4423389756 1.000000e+00 1.000000e+00 4 26319771 26319888 118 + 0.175 0.210 0.324
ENSG00000168214 E009 0.1817044 0.0430375613 1.833439e-01   4 26320563 26320699 137 + 0.000 0.214 20.099
ENSG00000168214 E010 1.5081155 0.0090272161 4.377530e-01 5.796451e-01 4 26320700 26320724 25 + 0.300 0.550 1.353
ENSG00000168214 E011 2.6799924 0.0414639373 5.822965e-01 7.066629e-01 4 26320725 26320786 62 + 0.522 0.548 0.125
ENSG00000168214 E012 2.5315975 0.0867992568 9.730178e-01 9.871595e-01 4 26320787 26320806 20 + 0.475 0.616 0.656
ENSG00000168214 E013 2.8208987 0.1227909346 5.810702e-01 7.056695e-01 4 26320807 26320815 9 + 0.542 0.545 0.014
ENSG00000168214 E014 1.1655342 0.3356968550 1.438943e-01 2.533136e-01 4 26320816 26320960 145 + 0.365 0.000 -20.567
ENSG00000168214 E015 1.8605539 0.0179792773 9.624319e-02 1.847370e-01 4 26320961 26320974 14 + 0.452 0.214 -1.519
ENSG00000168214 E016 5.6625749 0.0313973170 7.518095e-01 8.381694e-01 4 26320975 26321002 28 + 0.740 0.829 0.357
ENSG00000168214 E017 8.8828373 0.0055380192 3.763893e-01 5.207123e-01 4 26321003 26321006 4 + 0.920 0.968 0.181
ENSG00000168214 E018 9.3267744 0.0044681798 2.638680e-01 4.017859e-01 4 26321007 26321010 4 + 0.945 0.968 0.085
ENSG00000168214 E019 10.5176796 0.0092156324 1.119798e-01 2.084581e-01 4 26321011 26321013 3 + 1.006 0.968 -0.142
ENSG00000168214 E020 11.2603811 0.0103843461 6.116720e-02 1.285892e-01 4 26321014 26321014 1 + 1.040 0.968 -0.267
ENSG00000168214 E021 11.2603811 0.0103843461 6.116720e-02 1.285892e-01 4 26321015 26321015 1 + 1.040 0.968 -0.267
ENSG00000168214 E022 12.7521270 0.0207263194 2.732683e-02 6.665962e-02 4 26321016 26321021 6 + 1.102 0.968 -0.490
ENSG00000168214 E023 27.5742586 0.0008398761 1.069762e-04 5.541941e-04 4 26321022 26321048 27 + 1.422 1.289 -0.461
ENSG00000168214 E024 0.1451727 0.0442943772 1.000000e+00   4 26321228 26321295 68 + 0.067 0.000 -18.413
ENSG00000168214 E025 0.1451727 0.0442943772 1.000000e+00   4 26321299 26321364 66 + 0.067 0.000 -18.413
ENSG00000168214 E026 0.2987644 0.0274729528 6.324924e-01   4 26321365 26321601 237 + 0.125 0.000 -19.511
ENSG00000168214 E027 0.2987644 0.0274729528 6.324924e-01   4 26321602 26321670 69 + 0.125 0.000 -19.511
ENSG00000168214 E028 0.7363589 0.0155906580 1.474643e-01 2.582425e-01 4 26321671 26321871 201 + 0.263 0.000 -20.845
ENSG00000168214 E029 0.1482932 0.0411597534 1.857372e-01   4 26322164 26322208 45 + 0.000 0.214 20.111
ENSG00000168214 E030 0.1482932 0.0411597534 1.857372e-01   4 26322209 26322227 19 + 0.000 0.214 20.111
ENSG00000168214 E031 0.1515154 0.0441271912 1.000000e+00   4 26322228 26322297 70 + 0.067 0.000 -18.415
ENSG00000168214 E032 0.1472490 0.0451211385 1.000000e+00   4 26322870 26322950 81 + 0.067 0.000 -18.407
ENSG00000168214 E033 0.0000000       4 26343140 26343161 22 +      
ENSG00000168214 E034 0.0000000       4 26343162 26343171 10 +      
ENSG00000168214 E035 0.0000000       4 26343172 26343182 11 +      
ENSG00000168214 E036 0.1515154 0.0441271912 1.000000e+00   4 26343183 26343223 41 + 0.067 0.000 -18.415
ENSG00000168214 E037 0.0000000       4 26344437 26344740 304 +      
ENSG00000168214 E038 0.0000000       4 26344741 26344782 42 +      
ENSG00000168214 E039 0.0000000       4 26359691 26359775 85 +      
ENSG00000168214 E040 0.1451727 0.0442943772 1.000000e+00   4 26362436 26362445 10 + 0.067 0.000 -18.413
ENSG00000168214 E041 17.8990607 0.0010232377 9.352732e-04 3.737522e-03 4 26362446 26362475 30 + 1.246 1.096 -0.535
ENSG00000168214 E042 21.5892965 0.0008577192 8.087557e-04 3.289852e-03 4 26362476 26362520 45 + 1.318 1.195 -0.432
ENSG00000168214 E043 15.5480336 0.0013249816 6.677607e-03 2.038533e-02 4 26362521 26362529 9 + 1.180 1.073 -0.383
ENSG00000168214 E044 22.6949584 0.0009815703 3.859067e-05 2.232673e-04 4 26362530 26362580 51 + 1.351 1.158 -0.680
ENSG00000168214 E045 20.9616935 0.0009151301 1.433095e-04 7.179193e-04 4 26362581 26362628 48 + 1.314 1.138 -0.621
ENSG00000168214 E046 0.0000000       4 26366604 26366726 123 +      
ENSG00000168214 E047 0.1482932 0.0411597534 1.857372e-01   4 26367874 26368145 272 + 0.000 0.214 20.111
ENSG00000168214 E048 0.3666179 0.0430095685 4.872150e-01 6.248912e-01 4 26383885 26383960 76 + 0.067 0.215 1.944
ENSG00000168214 E049 0.5117906 0.3042756605 7.716405e-01 8.526092e-01 4 26383961 26384125 165 + 0.124 0.218 0.973
ENSG00000168214 E050 0.4720498 0.2313879665 8.067458e-01 8.772361e-01 4 26384126 26384528 403 + 0.124 0.215 0.947
ENSG00000168214 E051 0.0000000       4 26384529 26384608 80 +      
ENSG00000168214 E052 0.0000000       4 26385917 26386072 156 +      
ENSG00000168214 E053 41.7358269 0.0005589681 8.727102e-06 5.877647e-05 4 26386353 26386391 39 + 1.592 1.482 -0.377
ENSG00000168214 E054 58.6342606 0.0004062461 1.401358e-10 2.412605e-09 4 26406175 26406270 96 + 1.748 1.564 -0.624
ENSG00000168214 E055 0.2903454 0.3692150731 7.632347e-01   4 26408060 26408174 115 + 0.124 0.000 -18.612
ENSG00000168214 E056 0.6017953 0.1601447795 2.783435e-01 4.180184e-01 4 26410042 26410292 251 + 0.222 0.000 -19.894
ENSG00000168214 E057 0.1451727 0.0442943772 1.000000e+00   4 26412930 26412987 58 + 0.067 0.000 -18.413
ENSG00000168214 E058 0.4502799 0.0306076629 3.699863e-01 5.143972e-01 4 26414049 26414155 107 + 0.176 0.000 -20.042
ENSG00000168214 E059 79.7724969 0.0003382102 1.480275e-07 1.454758e-06 4 26415475 26415640 166 + 1.857 1.794 -0.214
ENSG00000168214 E060 43.8887671 0.0005118767 1.450348e-03 5.474696e-03 4 26420551 26420569 19 + 1.590 1.572 -0.061
ENSG00000168214 E061 97.6897212 0.0006494763 1.637752e-04 8.082574e-04 4 26420570 26420725 156 + 1.922 1.943 0.070
ENSG00000168214 E062 6.5509677 0.0151946594 1.296644e-04 6.573155e-04 4 26420726 26422131 1406 + 0.902 0.357 -2.451
ENSG00000168214 E063 0.5891098 0.0183382699 2.290270e-01 3.612726e-01 4 26422132 26422156 25 + 0.221 0.000 -20.528
ENSG00000168214 E064 8.9005101 0.0019019516 3.644605e-05 2.121227e-04 4 26422157 26424341 2185 + 1.006 0.550 -1.842
ENSG00000168214 E065 95.9079932 0.0043792344 1.131779e-04 5.824360e-04 4 26424342 26424479 138 + 1.927 1.896 -0.106
ENSG00000168214 E066 72.3755134 0.0022926381 2.122960e-04 1.016552e-03 4 26424631 26424743 113 + 1.806 1.788 -0.060
ENSG00000168214 E067 0.8900644 0.0674895993 1.127148e-01 2.095039e-01 4 26424744 26424994 251 + 0.300 0.000 -20.751
ENSG00000168214 E068 0.1472490 0.0451211385 1.000000e+00   4 26428613 26428719 107 + 0.067 0.000 -18.407
ENSG00000168214 E069 81.1199143 0.0005302043 7.575731e-07 6.459916e-06 4 26428720 26428860 141 + 1.863 1.815 -0.162
ENSG00000168214 E070 2.3281217 0.0110169167 8.896992e-01 9.334998e-01 4 26428861 26429897 1037 + 0.451 0.550 0.479
ENSG00000168214 E071 81.2933132 0.0003366663 2.265876e-03 8.048437e-03 4 26429898 26430053 156 + 1.841 1.885 0.151
ENSG00000168214 E072 3.7235228 0.0159003323 1.509152e-02 4.069291e-02 4 26430054 26430145 92 + 0.683 0.357 -1.585
ENSG00000168214 E073 6.6985930 0.0035579612 7.471989e-03 2.244227e-02 4 26430146 26430418 273 + 0.874 0.622 -1.024
ENSG00000168214 E074 61.1085805 0.0003890735 4.696856e-01 6.089099e-01 4 26430419 26430522 104 + 1.690 1.832 0.478
ENSG00000168214 E075 1035.7582902 0.0094500000 1.027277e-13 2.916010e-12 4 26430692 26435131 4440 + 2.839 3.179 1.128