ENSG00000168175

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395468 ENSG00000168175 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPK1IP1L protein_coding protein_coding 67.93712 86.936 66.94311 2.432674 2.623739 -0.3769686 8.481735 12.2395585 7.327993 2.0446342 0.05844828 -0.73927232 0.12420000 0.14020000 0.1097333 -0.030466667 0.597974359 0.003551089 FALSE TRUE
ENST00000553976 ENSG00000168175 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPK1IP1L protein_coding processed_transcript 67.93712 86.936 66.94311 2.432674 2.623739 -0.3769686 18.334891 31.0565652 15.019708 2.0422492 1.46482487 -1.04754574 0.26105833 0.35706667 0.2240000 -0.133066667 0.003551089 0.003551089 FALSE TRUE
ENST00000554364 ENSG00000168175 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPK1IP1L protein_coding processed_transcript 67.93712 86.936 66.94311 2.432674 2.623739 -0.3769686 24.163492 28.9462642 21.740368 2.7090053 2.20489827 -0.41283565 0.35811250 0.33270000 0.3244667 -0.008233333 0.969981479 0.003551089 FALSE FALSE
ENST00000622254 ENSG00000168175 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPK1IP1L protein_coding protein_coding 67.93712 86.936 66.94311 2.432674 2.623739 -0.3769686 10.496756 12.5985521 12.707978 0.8648964 0.27383394 0.01246668 0.15535417 0.14563333 0.1906667 0.045033333 0.217808570 0.003551089 TRUE TRUE
MSTRG.9580.2 ENSG00000168175 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPK1IP1L protein_coding   67.93712 86.936 66.94311 2.432674 2.623739 -0.3769686 4.018321 0.9814788 7.209028 0.9814788 0.56630908 2.86415084 0.06113333 0.01176667 0.1076000 0.095833333 0.048581125 0.003551089 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168175 E001 1.249207 0.0184186676 7.227532e-02 1.471235e-01 14 55051640 55051646 7 + 0.508 0.197 -1.954
ENSG00000168175 E002 86.864312 0.0118057439 4.441848e-01 5.857544e-01 14 55051647 55051682 36 + 1.956 1.916 -0.137
ENSG00000168175 E003 112.404950 0.0124554119 1.467050e-01 2.572066e-01 14 55051683 55051690 8 + 2.091 2.008 -0.277
ENSG00000168175 E004 366.175226 0.0028069516 1.408600e-04 7.072570e-04 14 55051691 55051803 113 + 2.615 2.509 -0.355
ENSG00000168175 E005 3.364289 0.0058964042 1.235013e-03 4.759445e-03 14 55054200 55054286 87 + 0.863 0.386 -2.136
ENSG00000168175 E006 15.681164 0.0264503130 3.025091e-05 1.798507e-04 14 55060362 55060997 636 + 1.435 0.968 -1.661
ENSG00000168175 E007 7.571794 0.1216452512 1.316007e-01 2.363615e-01 14 55060998 55061173 176 + 1.041 0.805 -0.891
ENSG00000168175 E008 269.306170 0.0001955801 5.389868e-12 1.171652e-10 14 55061680 55061701 22 + 2.499 2.362 -0.459
ENSG00000168175 E009 925.642640 0.0041132525 5.176346e-02 1.122985e-01 14 55062618 55062950 333 + 2.983 2.937 -0.153
ENSG00000168175 E010 1117.826616 0.0012667391 2.573184e-01 3.944061e-01 14 55062951 55063325 375 + 3.018 3.051 0.109
ENSG00000168175 E011 10.070210 0.0345675799 2.587946e-01 3.961174e-01 14 55063852 55063938 87 + 0.924 1.088 0.604
ENSG00000168175 E012 2805.721297 0.0007142754 6.337062e-06 4.408392e-05 14 55064616 55066206 1591 + 3.402 3.459 0.188
ENSG00000168175 E013 1004.204209 0.0054894504 7.654167e-02 1.539619e-01 14 55066207 55069108 2902 + 3.016 2.976 -0.134
ENSG00000168175 E014 253.484623 0.0197823897 1.871547e-06 1.465483e-05 14 55069109 55070194 1086 + 2.127 2.508 1.275