ENSG00000168090

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000303904 ENSG00000168090 HEK293_OSMI2_2hA HEK293_TMG_2hB COPS6 protein_coding protein_coding 165.2109 263.5707 113.9406 15.23985 1.212249 -1.209837 148.4019 249.7378 99.04098 15.62074 1.170535 -1.334229 0.8789375 0.947 0.8694333 -0.07756667 0.0001741181 9.994979e-08 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168090 E001 2.971642 0.2657963769 4.101240e-01 5.537428e-01 7 100088948 100088968 21 + 0.690 0.487 -0.911
ENSG00000168090 E002 17.384916 0.0221862194 7.792627e-02 1.561484e-01 7 100088969 100088974 6 + 1.333 1.135 -0.699
ENSG00000168090 E003 45.825296 0.0062243101 8.211943e-04 3.335180e-03 7 100088975 100088980 6 + 1.756 1.526 -0.779
ENSG00000168090 E004 61.294652 0.0130414964 1.507138e-02 4.064994e-02 7 100088981 100088981 1 + 1.850 1.663 -0.634
ENSG00000168090 E005 155.534862 0.0053686112 1.461192e-04 7.304304e-04 7 100088982 100088989 8 + 2.251 2.064 -0.625
ENSG00000168090 E006 168.205074 0.0061866462 1.945734e-04 9.407725e-04 7 100088990 100088992 3 + 2.286 2.098 -0.631
ENSG00000168090 E007 580.384579 0.0056767809 3.477659e-01 4.919668e-01 7 100088993 100089053 61 + 2.720 2.673 -0.157
ENSG00000168090 E008 597.797866 0.0056568859 5.809656e-01 7.056051e-01 7 100089054 100089066 13 + 2.721 2.690 -0.105
ENSG00000168090 E009 493.432624 0.0042206203 9.406172e-01 9.666865e-01 7 100089290 100089292 3 + 2.623 2.611 -0.038
ENSG00000168090 E010 1190.304048 0.0011119647 2.166190e-01 3.463253e-01 7 100089293 100089415 123 + 3.020 2.989 -0.103
ENSG00000168090 E011 11.095282 0.0016295726 5.103844e-05 2.869930e-04 7 100089416 100089614 199 + 1.285 0.875 -1.492
ENSG00000168090 E012 1790.875691 0.0006597125 4.292117e-01 5.719532e-01 7 100089615 100089746 132 + 3.170 3.175 0.019
ENSG00000168090 E013 53.089276 0.0204342223 4.322435e-15 1.500591e-13 7 100089747 100090361 615 + 2.064 1.389 -2.290
ENSG00000168090 E014 8.868423 0.1019913676 2.901917e-04 1.339994e-03 7 100090362 100090398 37 + 1.323 0.669 -2.448
ENSG00000168090 E015 1051.713252 0.0000828711 4.996278e-01 6.359164e-01 7 100090399 100090427 29 + 2.941 2.948 0.023
ENSG00000168090 E016 840.629692 0.0001163163 1.059490e-05 7.001191e-05 7 100090428 100090436 9 + 2.798 2.863 0.215
ENSG00000168090 E017 1208.018709 0.0002415092 2.131064e-04 1.020148e-03 7 100090437 100090487 51 + 2.968 3.017 0.162
ENSG00000168090 E018 15.246205 0.0303252992 2.710130e-01 4.097089e-01 7 100090488 100090591 104 + 1.246 1.105 -0.502
ENSG00000168090 E019 1471.566235 0.0002511312 3.522277e-01 4.965028e-01 7 100090592 100090654 63 + 3.085 3.094 0.031
ENSG00000168090 E020 36.673978 0.0103515000 2.295391e-12 5.310232e-11 7 100090655 100090901 247 + 1.847 1.314 -1.820
ENSG00000168090 E021 1293.862788 0.0009073958 9.967386e-01 1.000000e+00 7 100090902 100090949 48 + 3.037 3.034 -0.012
ENSG00000168090 E022 40.070848 0.0123405012 1.038725e-07 1.051755e-06 7 100090950 100091037 88 + 1.822 1.406 -1.417
ENSG00000168090 E023 2144.101820 0.0003234781 7.053873e-01 8.037626e-01 7 100091038 100091152 115 + 3.260 3.252 -0.027
ENSG00000168090 E024 32.978636 0.0071452489 5.286332e-12 1.151391e-10 7 100091153 100091237 85 + 1.784 1.279 -1.735
ENSG00000168090 E025 1716.748070 0.0002100692 9.607217e-01 9.792615e-01 7 100091238 100091307 70 + 3.160 3.158 -0.007
ENSG00000168090 E026 1128.321082 0.0003424492 3.453295e-01 4.894375e-01 7 100091308 100091330 23 + 2.968 2.979 0.038
ENSG00000168090 E027 1863.885768 0.0006032030 1.361532e-01 2.426991e-01 7 100091420 100091520 101 + 3.179 3.196 0.057
ENSG00000168090 E028 2210.982259 0.0004860368 2.057182e-03 7.402502e-03 7 100091649 100092187 539 + 3.239 3.275 0.120