ENSG00000168078

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301905 ENSG00000168078 HEK293_OSMI2_2hA HEK293_TMG_2hB PBK protein_coding protein_coding 13.18347 5.142397 21.057 0.6744826 0.3137455 2.031669 11.782805 4.9381350 18.499656 0.5637116 0.5112655 1.903321 0.91350833 0.9642 0.8782667 -0.08593333 0.0304341 0.0304341 FALSE  
ENST00000522944 ENSG00000168078 HEK293_OSMI2_2hA HEK293_TMG_2hB PBK protein_coding protein_coding 13.18347 5.142397 21.057 0.6744826 0.3137455 2.031669 1.296364 0.1457156 2.274496 0.1457156 0.1420327 3.874891 0.07471667 0.0225 0.1081667 0.08566667 0.1262992 0.0304341 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168078 E001 0.4439371 0.0215703417 5.217735e-01 6.556610e-01 8 27809165 27809623 459 - 0.184 0.000 -10.468
ENSG00000168078 E002 124.7345390 0.0003658555 2.332650e-09 3.231070e-08 8 27809624 27810200 577 - 1.986 2.188 0.677
ENSG00000168078 E003 87.8411125 0.0066139265 2.258783e-02 5.689395e-02 8 27810201 27810293 93 - 1.858 1.988 0.437
ENSG00000168078 E004 174.5904360 0.0017739062 7.228372e-02 1.471374e-01 8 27810294 27810501 208 - 2.173 2.238 0.215
ENSG00000168078 E005 184.4992350 0.0002275380 9.130259e-01 9.488936e-01 8 27810958 27811134 177 - 2.215 2.216 0.004
ENSG00000168078 E006 0.5514428 0.0203172110 5.513270e-03 1.732098e-02 8 27811135 27811167 33 - 0.000 0.449 13.758
ENSG00000168078 E007 95.4141755 0.0003038898 2.592745e-01 3.966630e-01 8 27820565 27820603 39 - 1.939 1.897 -0.143
ENSG00000168078 E008 126.4112957 0.0002652705 3.285371e-01 4.720364e-01 8 27820604 27820694 91 - 2.058 2.028 -0.102
ENSG00000168078 E009 149.3835001 0.0003605499 6.337205e-02 1.323096e-01 8 27822319 27822488 170 - 2.137 2.079 -0.194
ENSG00000168078 E010 116.7618908 0.0027851223 2.457056e-02 6.099321e-02 8 27823063 27823205 143 - 2.040 1.943 -0.327
ENSG00000168078 E011 94.9591291 0.0016537165 8.295769e-02 1.641744e-01 8 27828105 27828198 94 - 1.946 1.869 -0.259
ENSG00000168078 E012 0.9704895 0.0938578597 7.620688e-01 8.457624e-01 8 27833042 27833055 14 - 0.274 0.206 -0.532
ENSG00000168078 E013 91.4350417 0.0004151225 1.298165e-01 2.339016e-01 8 27833056 27833133 78 - 1.924 1.862 -0.208
ENSG00000168078 E014 65.3891103 0.0004185046 9.270212e-02 1.793501e-01 8 27837652 27837709 58 - 1.785 1.703 -0.277
ENSG00000168078 E015 67.6271152 0.0004110118 2.659042e-01 4.040130e-01 8 27837710 27838082 373 - 1.794 1.743 -0.173