ENSG00000168071

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301897 ENSG00000168071 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC88B protein_coding protein_coding 1.365905 2.775299 0.499969 0.1701146 0.09326848 -2.449351 0.39626261 0.80298190 0.11401089 0.40904190 0.11401089 -2.7127564 0.19583333 0.29786667 0.19330000 -0.10456667 0.768000468 0.008890377 FALSE TRUE
ENST00000356786 ENSG00000168071 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC88B protein_coding protein_coding 1.365905 2.775299 0.499969 0.1701146 0.09326848 -2.449351 0.18849210 0.18382398 0.07974015 0.09449933 0.04819616 -1.1109216 0.20212083 0.06983333 0.13413333 0.06430000 0.756618439 0.008890377 FALSE TRUE
ENST00000359902 ENSG00000168071 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC88B protein_coding protein_coding 1.365905 2.775299 0.499969 0.1701146 0.09326848 -2.449351 0.07462293 0.17248437 0.00000000 0.11305229 0.00000000 -4.1897010 0.03691250 0.05856667 0.00000000 -0.05856667 0.585741961 0.008890377 FALSE TRUE
ENST00000463837 ENSG00000168071 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC88B protein_coding processed_transcript 1.365905 2.775299 0.499969 0.1701146 0.09326848 -2.449351 0.04783390 0.08236350 0.06233229 0.08236350 0.06233229 -0.3526829 0.05331250 0.02800000 0.19883333 0.17083333 0.847282179 0.008890377 TRUE TRUE
ENST00000472524 ENSG00000168071 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC88B protein_coding processed_transcript 1.365905 2.775299 0.499969 0.1701146 0.09326848 -2.449351 0.37746964 1.21883962 0.09579229 0.44685253 0.09579229 -3.5379903 0.21806667 0.43123333 0.16053333 -0.27070000 0.381115194 0.008890377 FALSE TRUE
ENST00000479965 ENSG00000168071 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC88B protein_coding processed_transcript 1.365905 2.775299 0.499969 0.1701146 0.09326848 -2.449351 0.05941313 0.06586877 0.05206646 0.02423503 0.01833157 -0.2896923 0.06678333 0.02480000 0.09703333 0.07223333 0.138967844 0.008890377 FALSE TRUE
ENST00000492980 ENSG00000168071 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC88B protein_coding processed_transcript 1.365905 2.775299 0.499969 0.1701146 0.09326848 -2.449351 0.03927734 0.08488776 0.03595177 0.02660234 0.03595177 -1.0461015 0.06752500 0.02960000 0.11470000 0.08510000 0.910035294 0.008890377 FALSE TRUE
ENST00000494080 ENSG00000168071 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC88B protein_coding processed_transcript 1.365905 2.775299 0.499969 0.1701146 0.09326848 -2.449351 0.06626718 0.16404877 0.01520276 0.08908856 0.01520276 -2.7878381 0.05337500 0.06006667 0.02576667 -0.03430000 0.909251163 0.008890377 TRUE TRUE
ENST00000494566 ENSG00000168071 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC88B protein_coding processed_transcript 1.365905 2.775299 0.499969 0.1701146 0.09326848 -2.449351 0.10533512 0.00000000 0.04487239 0.00000000 0.02273315 2.4560805 0.09557083 0.00000000 0.07570000 0.07570000 0.008890377 0.008890377 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168071 E001 0.0000000       11 64340204 64340222 19 +      
ENSG00000168071 E002 0.0000000       11 64340223 64340326 104 +      
ENSG00000168071 E003 0.1472490 0.043632674 0.108718719   11 64340607 64340752 146 + 0.217 0.000 -11.016
ENSG00000168071 E004 1.5823102 0.011432972 0.362320187 0.506702635 11 64340907 64341018 112 + 0.470 0.297 -0.993
ENSG00000168071 E005 1.4789692 0.009676551 0.103328382 0.195545242 11 64341109 64341178 70 + 0.556 0.259 -1.673
ENSG00000168071 E006 1.6744919 0.010605882 0.038204913 0.087735237 11 64341270 64341328 59 + 0.628 0.259 -1.995
ENSG00000168071 E007 1.9658669 0.009730061 0.220504871 0.351015355 11 64341421 64341504 84 + 0.556 0.331 -1.185
ENSG00000168071 E008 0.5911836 0.025389472 0.598753273 0.720294712 11 64341599 64341605 7 + 0.000 0.173 11.311
ENSG00000168071 E009 1.6680474 0.009012534 0.464280799 0.604016886 11 64341606 64341742 137 + 0.470 0.330 -0.774
ENSG00000168071 E010 2.1432176 0.007243862 0.368204712 0.512609880 11 64341994 64342139 146 + 0.556 0.392 -0.826
ENSG00000168071 E011 1.2866808 0.021448122 0.741633429 0.830712679 11 64342294 64342375 82 + 0.362 0.296 -0.414
ENSG00000168071 E012 0.0000000       11 64342502 64342521 20 +      
ENSG00000168071 E013 1.4695191 0.274950619 0.057692663 0.122670565 11 64342522 64342680 159 + 0.629 0.220 -2.305
ENSG00000168071 E014 0.0000000       11 64342731 64342807 77 +      
ENSG00000168071 E015 1.0006785 0.014097319 0.014760988 0.039952352 11 64343179 64343325 147 + 0.556 0.123 -2.993
ENSG00000168071 E016 0.0000000       11 64343326 64343330 5 +      
ENSG00000168071 E017 0.7019140 0.017567771 0.187808078 0.310977173 11 64343507 64343538 32 + 0.362 0.123 -1.993
ENSG00000168071 E018 1.3953203 0.056545733 0.757698257 0.842429848 11 64343539 64343615 77 + 0.362 0.297 -0.406
ENSG00000168071 E019 1.9435409 0.009945725 0.319083657 0.462116364 11 64343778 64343914 137 + 0.217 0.420 1.328
ENSG00000168071 E020 13.5083854 0.002160030 0.093374112 0.180391508 11 64343997 64345157 1161 + 1.184 1.013 -0.621
ENSG00000168071 E021 0.0000000       11 64348831 64349052 222 +      
ENSG00000168071 E022 2.5723915 0.006451638 0.235247567 0.368653561 11 64349331 64349458 128 + 0.628 0.420 -0.994
ENSG00000168071 E023 2.9014441 0.016040239 0.650966133 0.761935351 11 64349551 64349668 118 + 0.556 0.472 -0.403
ENSG00000168071 E024 0.2966881 0.029078516 0.020732986   11 64349669 64349890 222 + 0.362 0.000 -14.578
ENSG00000168071 E025 1.8142523 0.008868195 0.061114411 0.128509577 11 64349891 64350695 805 + 0.628 0.296 -1.732
ENSG00000168071 E026 3.4476755 0.223389288 0.833162587 0.895470755 11 64351160 64351255 96 + 0.469 0.557 0.423
ENSG00000168071 E027 2.3144001 0.025616594 0.383757728 0.527956707 11 64351256 64351475 220 + 0.556 0.393 -0.817
ENSG00000168071 E028 5.0288413 0.072600704 0.598901111 0.720422238 11 64351476 64351616 141 + 0.743 0.653 -0.376
ENSG00000168071 E029 5.9928968 0.009487341 0.769916781 0.851444625 11 64352130 64352386 257 + 0.690 0.734 0.182
ENSG00000168071 E030 3.1614973 0.060273956 0.792478388 0.867317465 11 64352744 64352885 142 + 0.470 0.522 0.254
ENSG00000168071 E031 2.1013859 0.007147504 0.755975819 0.841163572 11 64352886 64352887 2 + 0.362 0.420 0.327
ENSG00000168071 E032 0.3332198 0.028021761 0.317302660   11 64352888 64353053 166 + 0.217 0.066 -1.995
ENSG00000168071 E033 4.9067768 0.003552304 0.338074672 0.481942242 11 64353054 64353240 187 + 0.792 0.646 -0.603
ENSG00000168071 E034 0.1482932 0.041837384 1.000000000   11 64353241 64353350 110 + 0.000 0.065 9.932
ENSG00000168071 E035 3.1259081 0.005746056 0.094242135 0.181758300 11 64353351 64353420 70 + 0.217 0.558 2.007
ENSG00000168071 E036 5.0874213 0.003375883 0.686002574 0.788587131 11 64353421 64353496 76 + 0.628 0.691 0.268
ENSG00000168071 E037 6.3387018 0.002735986 0.909971667 0.946768334 11 64353715 64353813 99 + 0.744 0.758 0.056
ENSG00000168071 E038 4.3146326 0.003951991 0.319063479 0.462101691 11 64354004 64354028 25 + 0.470 0.646 0.813
ENSG00000168071 E039 6.2646194 0.002924318 0.761754616 0.845544462 11 64354029 64354170 142 + 0.792 0.746 -0.187
ENSG00000168071 E040 11.4582286 0.012719372 0.868156397 0.919204726 11 64355194 64355342 149 + 0.975 0.996 0.077
ENSG00000168071 E041 13.4050763 0.001421907 0.167276651 0.284657448 11 64355343 64355400 58 + 0.911 1.070 0.590
ENSG00000168071 E042 6.0533934 0.097766304 0.707392024 0.805334492 11 64355401 64355559 159 + 0.691 0.769 0.321
ENSG00000168071 E043 15.3038432 0.002140264 0.046071098 0.102164687 11 64355560 64355628 69 + 0.911 1.137 0.829
ENSG00000168071 E044 1.6210320 0.071305167 0.912459786 0.948523788 11 64355629 64357038 1410 + 0.362 0.333 -0.177
ENSG00000168071 E045 28.2127032 0.009258514 0.001676443 0.006207675 11 64357039 64357534 496 + 1.081 1.388 1.086