ENSG00000168067

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000294066 ENSG00000168067 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP4K2 protein_coding protein_coding 5.288762 8.904453 3.937224 0.65975 0.2672354 -1.175308 0.2816864 0.1731358 0.3822417 0.0391010 0.01022543 1.0988290 0.06646667 0.01940000 0.09796667 0.078566667 4.198639e-05 4.198639e-05 FALSE TRUE
ENST00000377350 ENSG00000168067 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP4K2 protein_coding protein_coding 5.288762 8.904453 3.937224 0.65975 0.2672354 -1.175308 1.2786694 2.1563214 0.9655641 0.2228742 0.04919884 -1.1509388 0.22876250 0.24100000 0.24863333 0.007633333 9.694115e-01 4.198639e-05 FALSE TRUE
ENST00000467689 ENSG00000168067 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP4K2 protein_coding retained_intron 5.288762 8.904453 3.937224 0.65975 0.2672354 -1.175308 0.6084155 0.8101741 0.6269410 0.1408475 0.17781728 -0.3647705 0.12962083 0.08986667 0.15456667 0.064700000 3.979149e-01 4.198639e-05 FALSE FALSE
ENST00000470088 ENSG00000168067 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP4K2 protein_coding retained_intron 5.288762 8.904453 3.937224 0.65975 0.2672354 -1.175308 0.2810851 0.2067143 0.1699813 0.1483646 0.02896290 -0.2679470 0.06059583 0.02613333 0.04346667 0.017333333 6.275620e-01 4.198639e-05 FALSE TRUE
MSTRG.5683.3 ENSG00000168067 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP4K2 protein_coding   5.288762 8.904453 3.937224 0.65975 0.2672354 -1.175308 2.3939632 5.0140312 1.5653979 0.3830884 0.15482910 -1.6731292 0.41835833 0.56323333 0.39623333 -0.167000000 2.215224e-03 4.198639e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168067 E001 25.2332880 0.0033719681 1.420775e-21 1.081405e-19 11 64784918 64788817 3900 - 1.749 1.058 -2.402
ENSG00000168067 E002 4.7178916 0.0033938035 7.700568e-04 3.150115e-03 11 64788818 64789136 319 - 0.993 0.537 -1.852
ENSG00000168067 E003 80.3269493 0.0025756727 7.251259e-03 2.187885e-02 11 64789137 64789536 400 - 1.732 1.871 0.467
ENSG00000168067 E004 52.9984388 0.0021805784 1.317544e-01 2.365631e-01 11 64789537 64789624 88 - 1.596 1.685 0.301
ENSG00000168067 E005 43.7346622 0.0043831569 2.382003e-01 3.720547e-01 11 64789730 64789785 56 - 1.528 1.607 0.270
ENSG00000168067 E006 52.8704746 0.0026605594 5.372190e-01 6.688344e-01 11 64789889 64789959 71 - 1.639 1.675 0.120
ENSG00000168067 E007 51.9349819 0.0004360385 2.564346e-01 3.933984e-01 11 64790188 64790274 87 - 1.607 1.669 0.210
ENSG00000168067 E008 35.6552988 0.0006326302 7.201155e-02 1.466796e-01 11 64790394 64790450 57 - 1.405 1.527 0.418
ENSG00000168067 E009 21.7697656 0.0014812971 4.486488e-01 5.899243e-01 11 64790451 64790462 12 - 1.246 1.309 0.220
ENSG00000168067 E010 31.7258263 0.0006914253 5.224595e-03 1.654216e-02 11 64791909 64791957 49 - 1.283 1.491 0.721
ENSG00000168067 E011 39.0874904 0.0087668121 2.751287e-03 9.525448e-03 11 64791958 64792086 129 - 1.338 1.585 0.852
ENSG00000168067 E012 1.1855048 0.0539981017 5.564365e-02 1.190850e-01 11 64792087 64792171 85 - 0.556 0.206 -2.100
ENSG00000168067 E013 35.1151851 0.0077990477 3.190336e-01 4.620722e-01 11 64792172 64792275 104 - 1.431 1.511 0.276
ENSG00000168067 E014 0.9921577 0.0126887075 7.875400e-01 8.639141e-01 11 64792276 64792363 88 - 0.309 0.259 -0.350
ENSG00000168067 E015 39.1833607 0.0007565094 7.776637e-01 8.569255e-01 11 64792364 64792422 59 - 1.528 1.545 0.057
ENSG00000168067 E016 59.2990579 0.0004520587 1.962354e-01 3.215180e-01 11 64796273 64796390 118 - 1.665 1.731 0.224
ENSG00000168067 E017 43.5891293 0.0005485826 5.085621e-01 6.439506e-01 11 64796493 64796553 61 - 1.554 1.592 0.131
ENSG00000168067 E018 45.0348243 0.0005830426 8.622414e-01 9.151566e-01 11 64796634 64796713 80 - 1.590 1.599 0.030
ENSG00000168067 E019 48.7171684 0.0005249568 1.444788e-01 2.541160e-01 11 64796809 64796893 85 - 1.566 1.650 0.283
ENSG00000168067 E020 0.6611159 0.0199224556 5.632097e-02 1.202818e-01 11 64796971 64796981 11 - 0.408 0.081 -2.932
ENSG00000168067 E021 37.2210838 0.0006024637 9.890615e-02 1.888021e-01 11 64796982 64797023 42 - 1.431 1.540 0.373
ENSG00000168067 E022 40.4269853 0.0011519042 4.831648e-01 6.212214e-01 11 64797104 64797168 65 - 1.521 1.564 0.147
ENSG00000168067 E023 22.5277555 0.0051772755 9.084129e-01 9.458535e-01 11 64797169 64797192 24 - 1.317 1.305 -0.041
ENSG00000168067 E024 49.4835612 0.0005367344 9.422147e-01 9.677301e-01 11 64797275 64797380 106 - 1.645 1.639 -0.018
ENSG00000168067 E025 6.3239437 0.0026518613 3.689078e-01 5.133234e-01 11 64797381 64797500 120 - 0.890 0.770 -0.465
ENSG00000168067 E026 27.6467580 0.0014372035 9.018457e-01 9.414473e-01 11 64797501 64797534 34 - 1.405 1.395 -0.035
ENSG00000168067 E027 32.5912573 0.0006586407 6.681942e-01 7.752590e-01 11 64797626 64797664 39 - 1.439 1.467 0.097
ENSG00000168067 E028 41.3459463 0.0005681008 4.859996e-01 6.238095e-01 11 64798794 64798837 44 - 1.590 1.547 -0.147
ENSG00000168067 E029 45.1192661 0.0005089938 8.154384e-01 8.831500e-01 11 64799421 64799479 59 - 1.607 1.593 -0.050
ENSG00000168067 E030 43.6990055 0.0046107110 4.529415e-01 5.937476e-01 11 64799605 64799683 79 - 1.618 1.569 -0.169
ENSG00000168067 E031 35.7935694 0.0006345486 5.196034e-01 6.536809e-01 11 64800109 64800181 73 - 1.528 1.485 -0.146
ENSG00000168067 E032 29.6628933 0.0007542359 7.544726e-01 8.401077e-01 11 64800182 64800216 35 - 1.405 1.426 0.073
ENSG00000168067 E033 27.0497923 0.0028424812 9.469090e-01 9.706712e-01 11 64800311 64800335 25 - 1.387 1.381 -0.021
ENSG00000168067 E034 21.7610697 0.0107871319 9.327480e-01 9.616249e-01 11 64800336 64800347 12 - 1.283 1.293 0.033
ENSG00000168067 E035 30.8570933 0.0014388156 5.809209e-01 7.055735e-01 11 64800348 64800392 45 - 1.463 1.423 -0.138
ENSG00000168067 E036 27.4120799 0.0007764997 6.080031e-01 7.278685e-01 11 64800764 64800799 36 - 1.358 1.395 0.129
ENSG00000168067 E037 21.9779326 0.0008744064 3.596560e-01 5.039905e-01 11 64800800 64800826 27 - 1.233 1.309 0.267
ENSG00000168067 E038 19.7421536 0.0009780367 5.719541e-02 1.217964e-01 11 64800900 64801031 132 - 1.358 1.201 -0.551
ENSG00000168067 E039 31.6393045 0.0041220437 9.733297e-01 9.873440e-01 11 64801111 64801183 73 - 1.439 1.441 0.007
ENSG00000168067 E040 25.8060992 0.0147588263 8.192323e-01 8.858561e-01 11 64801579 64801621 43 - 1.338 1.364 0.088
ENSG00000168067 E041 28.5095621 0.0172454394 2.163716e-01 3.460378e-01 11 64801710 64801757 48 - 1.479 1.369 -0.378
ENSG00000168067 E042 0.0000000       11 64801758 64801813 56 -      
ENSG00000168067 E043 28.1007146 0.0009092325 3.844668e-02 8.818782e-02 11 64802066 64802121 56 - 1.500 1.355 -0.504
ENSG00000168067 E044 30.8034663 0.0031873881 7.984677e-02 1.593277e-01 11 64802419 64802483 65 - 1.528 1.403 -0.431
ENSG00000168067 E045 26.1025668 0.0007700540 1.243671e-01 2.262102e-01 11 64802563 64802627 65 - 1.447 1.334 -0.391
ENSG00000168067 E046 13.8709549 0.0012949648 1.658798e-01 2.828394e-01 11 64802628 64802630 3 - 1.206 1.072 -0.480
ENSG00000168067 E047 16.1153381 0.0011621291 1.307807e-01 2.352384e-01 11 64802631 64802653 23 - 1.271 1.135 -0.483
ENSG00000168067 E048 21.7209694 0.0008971572 9.228511e-02 1.786947e-01 11 64802885 64802942 58 - 1.387 1.253 -0.466
ENSG00000168067 E049 1.8403016 0.0086314935 5.638094e-01 6.912241e-01 11 64802943 64803053 111 - 0.488 0.385 -0.543
ENSG00000168067 E050 15.7447576 0.0027315933 2.062630e-02 5.279743e-02 11 64803054 64803241 188 - 1.306 1.094 -0.750