ENSG00000168056

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301873 ENSG00000168056 HEK293_OSMI2_2hA HEK293_TMG_2hB LTBP3 protein_coding protein_coding 16.1043 20.683 13.22736 1.930693 0.5571273 -0.6445268 1.107290 1.383452 1.051493 0.3723773 0.1114272 -0.3925692 0.0633250 0.0663000 0.08013333 0.01383333 7.925491e-01 1.655296e-15 FALSE TRUE
ENST00000322147 ENSG00000168056 HEK293_OSMI2_2hA HEK293_TMG_2hB LTBP3 protein_coding protein_coding 16.1043 20.683 13.22736 1.930693 0.5571273 -0.6445268 4.629832 7.321754 3.496938 0.6500847 0.6203805 -1.0639467 0.2668500 0.3551667 0.26153333 -0.09363333 2.988316e-01 1.655296e-15 FALSE TRUE
ENST00000529189 ENSG00000168056 HEK293_OSMI2_2hA HEK293_TMG_2hB LTBP3 protein_coding retained_intron 16.1043 20.683 13.22736 1.930693 0.5571273 -0.6445268 2.627782 4.847654 1.347951 0.6051225 0.2069811 -1.8388283 0.1547542 0.2383667 0.10143333 -0.13693333 1.028687e-02 1.655296e-15 FALSE TRUE
ENST00000532661 ENSG00000168056 HEK293_OSMI2_2hA HEK293_TMG_2hB LTBP3 protein_coding protein_coding 16.1043 20.683 13.22736 1.930693 0.5571273 -0.6445268 1.902349 3.528349 1.191472 0.6267849 0.2205038 -1.5582731 0.1035625 0.1685000 0.08896667 -0.07953333 3.486802e-02 1.655296e-15 FALSE TRUE
MSTRG.5727.15 ENSG00000168056 HEK293_OSMI2_2hA HEK293_TMG_2hB LTBP3 protein_coding   16.1043 20.683 13.22736 1.930693 0.5571273 -0.6445268 1.256989 0.000000 2.327428 0.0000000 0.4587865 7.8687781 0.1187667 0.0000000 0.17950000 0.17950000 1.655296e-15 1.655296e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168056 E001 1.9176950 0.0153521022 2.537433e-01 3.903317e-01 11 65538559 65538569 11 - 0.548 0.354 -1.011
ENSG00000168056 E002 16.8128349 0.0156537900 3.673048e-01 5.116679e-01 11 65538570 65538804 235 - 1.162 1.260 0.349
ENSG00000168056 E003 10.1320871 0.0017157582 3.891354e-01 5.332446e-01 11 65538805 65538818 14 - 0.956 1.052 0.357
ENSG00000168056 E004 53.3446044 0.0051444563 6.902599e-04 2.863630e-03 11 65538819 65538902 84 - 1.552 1.771 0.745
ENSG00000168056 E005 79.3230879 0.0003458882 7.125666e-08 7.442174e-07 11 65538903 65538990 88 - 1.695 1.940 0.824
ENSG00000168056 E006 74.2511378 0.0003438078 1.914508e-04 9.272837e-04 11 65538991 65539051 61 - 1.720 1.892 0.579
ENSG00000168056 E007 51.6816158 0.0081326960 1.466389e-01 2.571179e-01 11 65539052 65539079 28 - 1.610 1.718 0.368
ENSG00000168056 E008 65.8959650 0.0041281386 1.729980e-02 4.560361e-02 11 65539080 65539231 152 - 1.692 1.831 0.472
ENSG00000168056 E009 24.3650243 0.0008272115 8.277723e-02 1.638981e-01 11 65539328 65539335 8 - 1.273 1.408 0.471
ENSG00000168056 E010 56.6442106 0.0004588788 5.373240e-05 3.003760e-04 11 65539336 65539418 83 - 1.572 1.787 0.729
ENSG00000168056 E011 66.4774645 0.0003886102 6.571586e-03 2.011288e-02 11 65539419 65539459 41 - 1.703 1.834 0.444
ENSG00000168056 E012 85.3454064 0.0022961330 5.874282e-02 1.244709e-01 11 65539548 65539628 81 - 1.839 1.931 0.311
ENSG00000168056 E013 137.9892193 0.0006496503 8.880505e-02 1.732899e-01 11 65539720 65539881 162 - 2.067 2.128 0.205
ENSG00000168056 E014 17.9152021 0.0372040214 1.034324e-01 1.957127e-01 11 65540013 65540153 141 - 1.361 1.172 -0.667
ENSG00000168056 E015 169.8577663 0.0002872521 7.388999e-04 3.038867e-03 11 65540245 65540382 138 - 2.127 2.231 0.346
ENSG00000168056 E016 1.0674852 0.2897068366 1.342223e-01 2.400273e-01 11 65540383 65540452 70 - 0.001 0.368 9.875
ENSG00000168056 E017 215.4761223 0.0036643685 5.860329e-01 7.096703e-01 11 65540486 65540614 129 - 2.286 2.315 0.097
ENSG00000168056 E018 15.9738252 0.0046988302 3.327891e-01 4.764690e-01 11 65540615 65540683 69 - 1.136 1.232 0.340
ENSG00000168056 E019 0.6664396 0.5160920755 7.093116e-01 8.067296e-01 11 65540797 65540870 74 - 0.267 0.178 -0.749
ENSG00000168056 E020 165.2811806 0.0022441982 8.133802e-01 8.816743e-01 11 65540871 65540954 84 - 2.181 2.196 0.050
ENSG00000168056 E021 1.1510600 0.0275577268 6.473233e-01 7.590067e-01 11 65540995 65541125 131 - 0.266 0.352 0.565
ENSG00000168056 E022 173.0920496 0.0060812129 5.604518e-01 6.884558e-01 11 65541126 65541293 168 - 2.191 2.225 0.114
ENSG00000168056 E023 136.6045526 0.0067720680 3.030637e-01 4.449737e-01 11 65541600 65541728 129 - 2.073 2.130 0.191
ENSG00000168056 E024 3.7121050 0.0412977539 6.307547e-03 1.942149e-02 11 65541729 65542366 638 - 0.889 0.442 -1.933
ENSG00000168056 E025 3.1815461 0.0198889745 7.534596e-01 8.393893e-01 11 65542407 65543104 698 - 0.548 0.604 0.253
ENSG00000168056 E026 78.3683851 0.0064974987 8.745479e-02 1.712796e-01 11 65543105 65543126 22 - 1.800 1.903 0.348
ENSG00000168056 E027 110.8591470 0.0002986892 7.094185e-03 2.147332e-02 11 65543127 65543224 98 - 1.947 2.048 0.339
ENSG00000168056 E028 123.3181938 0.0066841818 6.285910e-01 7.441165e-01 11 65543427 65543549 123 - 2.043 2.075 0.108
ENSG00000168056 E029 6.9094584 0.0042057159 2.338831e-02 5.855310e-02 11 65543550 65544063 514 - 1.030 0.761 -1.028
ENSG00000168056 E030 45.3794547 0.0004690096 9.501752e-02 1.829069e-01 11 65544064 65545770 1707 - 1.692 1.606 -0.291
ENSG00000168056 E031 3.9513056 0.0053375597 1.347890e-02 3.703194e-02 11 65546196 65546441 246 - 0.866 0.513 -1.488
ENSG00000168056 E032 93.6499499 0.0113699345 9.430346e-01 9.682668e-01 11 65546442 65546564 123 - 1.938 1.950 0.040
ENSG00000168056 E033 2.3313560 0.0064541823 2.218610e-02 5.605840e-02 11 65546565 65546759 195 - 0.718 0.353 -1.754
ENSG00000168056 E034 86.8761847 0.0146571632 6.965562e-01 7.968676e-01 11 65546798 65546920 123 - 1.927 1.907 -0.066
ENSG00000168056 E035 105.6747635 0.0002864706 3.996831e-01 5.434218e-01 11 65547439 65547567 129 - 2.014 1.987 -0.090
ENSG00000168056 E036 108.1182618 0.0003006098 6.506442e-01 7.616606e-01 11 65547690 65547821 132 - 2.012 1.999 -0.042
ENSG00000168056 E037 79.1312634 0.0003466233 6.612603e-01 7.697408e-01 11 65547920 65547969 50 - 1.880 1.865 -0.050
ENSG00000168056 E038 79.8329514 0.0004178427 3.115670e-02 7.420476e-02 11 65547970 65548018 49 - 1.930 1.845 -0.285
ENSG00000168056 E039 69.3373950 0.0005191797 9.588228e-02 1.842122e-01 11 65548019 65548045 27 - 1.857 1.787 -0.236
ENSG00000168056 E040 27.3944840 0.0007497388 2.870704e-04 1.327425e-03 11 65548046 65549437 1392 - 1.562 1.324 -0.822
ENSG00000168056 E041 95.9376872 0.0002923128 2.406243e-01 3.749028e-01 11 65551126 65551224 99 - 1.983 1.942 -0.136
ENSG00000168056 E042 81.8944774 0.0003884609 4.524044e-01 5.932652e-01 11 65551402 65551474 73 - 1.908 1.881 -0.091
ENSG00000168056 E043 2.4263797 0.0269125915 7.439176e-03 2.236002e-02 11 65551475 65551511 37 - 0.752 0.303 -2.205
ENSG00000168056 E044 1.6963530 0.0094460488 2.206710e-04 1.052292e-03 11 65551512 65551547 36 - 0.718 0.097 -4.074
ENSG00000168056 E045 60.3899774 0.0012158272 3.729240e-03 1.238093e-02 11 65551548 65551564 17 - 1.844 1.709 -0.457
ENSG00000168056 E046 12.8021279 0.0013774024 1.696362e-02 4.485599e-02 11 65551565 65551971 407 - 1.242 1.022 -0.790
ENSG00000168056 E047 111.2513564 0.0002517492 6.787002e-03 2.066933e-02 11 65551972 65552123 152 - 2.077 1.987 -0.300
ENSG00000168056 E048 53.7249152 0.0009141464 1.174245e-01 2.162745e-01 11 65552124 65552157 34 - 1.754 1.678 -0.256
ENSG00000168056 E049 104.2775446 0.0003059568 1.025977e-02 2.940540e-02 11 65552248 65552406 159 - 2.046 1.958 -0.296
ENSG00000168056 E050 88.3945506 0.0003528167 6.330296e-03 1.948203e-02 11 65552860 65552982 123 - 1.984 1.882 -0.343
ENSG00000168056 E051 70.6873447 0.0004019350 7.045510e-02 1.440929e-01 11 65553164 65553256 93 - 1.872 1.797 -0.253
ENSG00000168056 E052 57.5132049 0.0005246098 9.984188e-02 1.902432e-01 11 65553425 65553530 106 - 1.788 1.713 -0.255
ENSG00000168056 E053 67.6018334 0.0006369810 2.946238e-01 4.357359e-01 11 65553701 65553898 198 - 1.831 1.787 -0.148
ENSG00000168056 E054 20.8845497 0.0022976016 5.595883e-01 6.876802e-01 11 65553899 65553903 5 - 1.345 1.302 -0.149
ENSG00000168056 E055 3.5206437 0.0091849301 5.993900e-01 7.207906e-01 11 65553904 65554050 147 - 0.681 0.603 -0.336
ENSG00000168056 E056 84.6427245 0.0003626099 3.633765e-03 1.210852e-02 11 65554051 65554380 330 - 1.973 1.862 -0.374
ENSG00000168056 E057 25.0827902 0.0020484876 1.016097e-02 2.916128e-02 11 65557629 65557632 4 - 1.503 1.323 -0.621
ENSG00000168056 E058 40.8122889 0.0005604082 2.137492e-04 1.023019e-03 11 65557633 65557711 79 - 1.717 1.516 -0.683
ENSG00000168056 E059 42.9955064 0.0005338962 1.261058e-03 4.846602e-03 11 65557712 65558359 648 - 1.717 1.546 -0.583
ENSG00000168056 E060 0.9879044 0.2802776315 8.728237e-01 9.222367e-01 11 65558604 65559133 530 - 0.266 0.301 0.241