ENSG00000168010

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000439504 ENSG00000168010 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG16L2 protein_coding retained_intron 4.951665 6.953167 4.165828 0.304838 0.2241659 -0.7376814 0.3767402 0.2208669 0.4262651 0.03836869 0.04068472 0.9181438 0.0814875 0.03163333 0.1035000 0.071866667 6.073848e-03 8.218903e-08 TRUE TRUE
ENST00000536995 ENSG00000168010 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG16L2 protein_coding retained_intron 4.951665 6.953167 4.165828 0.304838 0.2241659 -0.7376814 0.2687754 0.1819876 0.1988340 0.10480474 0.06348858 0.1213434 0.0561500 0.02500000 0.0468000 0.021800000 5.375089e-01 8.218903e-08   FALSE
ENST00000540222 ENSG00000168010 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG16L2 protein_coding protein_coding 4.951665 6.953167 4.165828 0.304838 0.2241659 -0.7376814 0.3814238 0.8560088 0.5450418 0.47776872 0.15301906 -0.6417852 0.0730875 0.12763333 0.1352667 0.007633333 8.979244e-01 8.218903e-08 FALSE TRUE
ENST00000540567 ENSG00000168010 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG16L2 protein_coding protein_coding 4.951665 6.953167 4.165828 0.304838 0.2241659 -0.7376814 0.5723067 0.2339106 0.7761679 0.05692261 0.02223681 1.6884853 0.1318292 0.03310000 0.1880333 0.154933333 8.218903e-08 8.218903e-08 FALSE TRUE
ENST00000541367 ENSG00000168010 HEK293_OSMI2_2hA HEK293_TMG_2hB ATG16L2 protein_coding protein_coding 4.951665 6.953167 4.165828 0.304838 0.2241659 -0.7376814 2.0696479 3.9278605 1.0782487 0.51931547 0.16627569 -1.8554038 0.3897917 0.56260000 0.2562000 -0.306400000 1.309281e-03 8.218903e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168010 E001 0.4783925 0.0208977135 2.651043e-01 4.031306e-01 11 72814406 72814410 5 + 0.280 0.091 -1.948
ENSG00000168010 E002 0.8470867 0.0143721333 2.540614e-01 3.906877e-01 11 72814411 72814414 4 + 0.372 0.167 -1.532
ENSG00000168010 E003 0.8470867 0.0143721333 2.540614e-01 3.906877e-01 11 72814415 72814418 4 + 0.372 0.167 -1.532
ENSG00000168010 E004 1.1501176 0.0123431741 5.058314e-02 1.101925e-01 11 72814419 72814424 6 + 0.513 0.167 -2.269
ENSG00000168010 E005 1.1501176 0.0123431741 5.058314e-02 1.101925e-01 11 72814425 72814426 2 + 0.513 0.167 -2.269
ENSG00000168010 E006 1.1501176 0.0123431741 5.058314e-02 1.101925e-01 11 72814427 72814431 5 + 0.513 0.167 -2.269
ENSG00000168010 E007 6.6118425 0.0044527147 2.485652e-04 1.169181e-03 11 72814432 72814563 132 + 1.106 0.655 -1.741
ENSG00000168010 E008 0.4513240 0.1624175786 3.031807e-01 4.450765e-01 11 72815887 72816349 463 + 0.280 0.091 -1.965
ENSG00000168010 E009 4.6136071 0.0036071737 8.411809e-04 3.405945e-03 11 72816728 72816744 17 + 0.982 0.524 -1.874
ENSG00000168010 E010 9.7525163 0.0019240924 1.426706e-03 5.395559e-03 11 72816745 72816827 83 + 1.202 0.865 -1.238
ENSG00000168010 E011 11.8333524 0.0067177043 4.487690e-03 1.450744e-02 11 72817756 72817855 100 + 1.249 0.953 -1.067
ENSG00000168010 E012 15.1254403 0.0013189517 6.613831e-14 1.927806e-12 11 72817856 72819015 1160 + 1.508 0.851 -2.356
ENSG00000168010 E013 0.8459408 0.0155961399 8.063383e-01 8.768986e-01 11 72820137 72820143 7 + 0.280 0.231 -0.363
ENSG00000168010 E014 12.8755085 0.0016349909 9.544097e-04 3.802925e-03 11 72820144 72821198 1055 + 1.291 0.975 -1.135
ENSG00000168010 E015 5.9305495 0.0032073975 4.505728e-02 1.003004e-01 11 72821199 72821547 349 + 0.961 0.698 -1.029
ENSG00000168010 E016 3.8184381 0.2301442431 2.535279e-01 3.900509e-01 11 72821548 72821667 120 + 0.807 0.544 -1.114
ENSG00000168010 E017 7.5826626 0.0363628952 2.396032e-01 3.736530e-01 11 72821668 72821741 74 + 1.002 0.827 -0.660
ENSG00000168010 E018 2.0521950 0.0871881283 5.456735e-01 6.759796e-01 11 72821742 72821887 146 + 0.372 0.493 0.639
ENSG00000168010 E019 2.1327234 0.0073884347 3.997130e-01 5.434508e-01 11 72821888 72822043 156 + 0.570 0.422 -0.726
ENSG00000168010 E020 5.1427845 0.2265967229 2.267583e-01 3.585149e-01 11 72822044 72822188 145 + 0.915 0.651 -1.055
ENSG00000168010 E021 2.1275120 0.0543143437 6.467900e-01 7.585972e-01 11 72822189 72822233 45 + 0.513 0.425 -0.444
ENSG00000168010 E022 2.6927730 0.0199881259 6.814198e-01 7.851180e-01 11 72822234 72822295 62 + 0.570 0.494 -0.354
ENSG00000168010 E023 0.2998086 0.0293159608 6.425350e-01   11 72822322 72822340 19 + 0.162 0.091 -0.951
ENSG00000168010 E024 3.5052009 0.0045476271 6.626722e-01 7.709344e-01 11 72822341 72822430 90 + 0.570 0.632 0.275
ENSG00000168010 E025 4.6918371 0.0039916230 7.964801e-01 8.700936e-01 11 72822431 72822438 8 + 0.742 0.698 -0.182
ENSG00000168010 E026 8.9603120 0.0019938886 1.370356e-01 2.439644e-01 11 72822439 72822476 38 + 0.837 1.006 0.637
ENSG00000168010 E027 8.3346704 0.0021469323 3.776821e-02 8.690092e-02 11 72822477 72822477 1 + 0.742 0.996 0.978
ENSG00000168010 E028 12.3612269 0.0014880690 1.570994e-01 2.712368e-01 11 72822478 72822482 5 + 0.982 1.120 0.505
ENSG00000168010 E029 20.1932940 0.0009339760 4.201679e-02 9.475200e-02 11 72822483 72822543 61 + 1.163 1.325 0.572
ENSG00000168010 E030 5.5463979 0.0827139154 7.146128e-01 8.107438e-01 11 72822544 72822847 304 + 0.809 0.749 -0.239
ENSG00000168010 E031 34.0294712 0.0006499539 1.978102e-03 7.159008e-03 11 72822848 72822961 114 + 1.356 1.552 0.677
ENSG00000168010 E032 8.1866626 0.0021636987 9.119517e-03 2.658198e-02 11 72822962 72823543 582 + 1.106 0.806 -1.124
ENSG00000168010 E033 6.3076657 0.0027980679 2.216895e-03 7.896220e-03 11 72823544 72823765 222 + 1.057 0.677 -1.472
ENSG00000168010 E034 3.1420102 0.0071824069 1.310236e-02 3.614525e-02 11 72823766 72823797 32 + 0.808 0.422 -1.724
ENSG00000168010 E035 4.9197308 0.0038298157 5.276441e-03 1.668485e-02 11 72823798 72823894 97 + 0.961 0.581 -1.533
ENSG00000168010 E036 7.3083009 0.2019922398 2.135585e-01 3.427193e-01 11 72823895 72824059 165 + 1.020 0.803 -0.823
ENSG00000168010 E037 25.2868466 0.0008338666 3.465598e-02 8.099121e-02 11 72824060 72824122 63 + 1.270 1.420 0.521
ENSG00000168010 E038 17.2878717 0.0504772466 2.332693e-02 5.843128e-02 11 72824123 72824733 611 + 1.404 1.107 -1.048
ENSG00000168010 E039 36.0402802 0.0104991157 1.101467e-02 3.119687e-02 11 72824734 72824842 109 + 1.389 1.582 0.663
ENSG00000168010 E040 22.2598615 0.0009288680 1.487004e-01 2.599170e-01 11 72825302 72825348 47 + 1.249 1.353 0.366
ENSG00000168010 E041 25.0519004 0.0007743089 1.292933e-01 2.332006e-01 11 72825349 72825407 59 + 1.301 1.404 0.360
ENSG00000168010 E042 30.3107444 0.0009129020 3.062807e-02 7.319234e-02 11 72826173 72826243 71 + 1.347 1.488 0.487
ENSG00000168010 E043 34.1337685 0.0008050009 2.307590e-01 3.633664e-01 11 72826518 72826589 72 + 1.456 1.523 0.230
ENSG00000168010 E044 2.5464570 0.0074687808 1.461147e-01 2.564052e-01 11 72826590 72826702 113 + 0.664 0.422 -1.139
ENSG00000168010 E045 44.3964767 0.0006256657 9.002850e-02 1.751811e-01 11 72826703 72826823 121 + 1.554 1.640 0.293
ENSG00000168010 E046 2.1529730 0.0778636733 2.797588e-02 6.796459e-02 11 72826824 72827187 364 + 0.705 0.290 -2.104
ENSG00000168010 E047 35.5065253 0.0090222940 4.272922e-01 5.701252e-01 11 72827188 72827293 106 + 1.489 1.542 0.183
ENSG00000168010 E048 50.3128536 0.0094236850 2.522685e-01 3.885930e-01 11 72828359 72828508 150 + 1.625 1.692 0.230
ENSG00000168010 E049 2.4024422 0.0175137806 5.417717e-01 6.727052e-01 11 72828509 72828728 220 + 0.570 0.459 -0.531
ENSG00000168010 E050 30.7853891 0.0028087026 5.371465e-01 6.687884e-01 11 72828729 72828776 48 + 1.435 1.469 0.117
ENSG00000168010 E051 41.9950237 0.0012953341 1.147718e-03 4.463893e-03 11 72828883 72828984 102 + 1.456 1.644 0.645
ENSG00000168010 E052 44.6083110 0.0005667172 1.054404e-04 5.470756e-04 11 72829303 72829635 333 + 1.456 1.674 0.743
ENSG00000168010 E053 6.4536551 0.0039485622 3.834131e-03 1.267630e-02 11 72842617 72843674 1058 + 1.057 0.697 -1.385