ENSG00000168003

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338663 ENSG00000168003 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC3A2 protein_coding protein_coding 226.9937 274.6745 191.777 12.72097 2.104661 -0.5182704 87.126352 111.91571 71.99218971 11.439877 2.89750506 -0.6364288 0.38012917 0.4052667 0.3757000 -0.02956667 0.7500009569 0.0001310876 FALSE TRUE
ENST00000377890 ENSG00000168003 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC3A2 protein_coding protein_coding 226.9937 274.6745 191.777 12.72097 2.104661 -0.5182704 29.547531 36.51656 22.68368124 2.450559 0.12505571 -0.6866552 0.12906667 0.1328333 0.1182667 -0.01456667 0.2933530231 0.0001310876 FALSE TRUE
ENST00000536981 ENSG00000168003 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC3A2 protein_coding protein_coding 226.9937 274.6745 191.777 12.72097 2.104661 -0.5182704 7.255053 21.42056 0.09538301 8.336599 0.09538301 -7.6678833 0.02914583 0.0811000 0.0005000 -0.08060000 0.0002568356 0.0001310876 FALSE TRUE
ENST00000537508 ENSG00000168003 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC3A2 protein_coding processed_transcript 226.9937 274.6745 191.777 12.72097 2.104661 -0.5182704 42.447931 31.09338 50.14647248 6.877981 6.24212540 0.6893647 0.19423333 0.1120667 0.2609333 0.14886667 0.0060857977 0.0001310876   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168003 E001 1.951016 7.572977e-03 2.202195e-01 3.506792e-01 11 62856004 62856028 25 + 0.274 0.501 1.305
ENSG00000168003 E002 3.759958 4.631645e-03 9.030431e-01 9.423283e-01 11 62856029 62856045 17 + 0.655 0.641 -0.058
ENSG00000168003 E003 5.700379 3.438557e-03 5.649485e-01 6.921533e-01 11 62856046 62856053 8 + 0.732 0.816 0.337
ENSG00000168003 E004 18.215978 1.546120e-03 4.357609e-01 5.779485e-01 11 62856054 62856069 16 + 1.190 1.264 0.261
ENSG00000168003 E005 34.097663 5.982852e-04 3.145188e-01 4.572281e-01 11 62856070 62856101 32 + 1.458 1.529 0.245
ENSG00000168003 E006 38.063772 5.520881e-04 6.760665e-01 7.811586e-01 11 62856102 62856108 7 + 1.569 1.550 -0.063
ENSG00000168003 E007 37.438133 5.620525e-04 4.825799e-01 6.207155e-01 11 62856109 62856110 2 + 1.574 1.538 -0.122
ENSG00000168003 E008 136.549142 2.209157e-04 5.152838e-05 2.894043e-04 11 62856111 62856143 33 + 2.182 2.061 -0.406
ENSG00000168003 E009 221.643878 5.943688e-04 1.705559e-02 4.506018e-02 11 62856144 62856160 17 + 2.352 2.295 -0.193
ENSG00000168003 E010 235.125028 7.522210e-04 1.105473e-01 2.063336e-01 11 62856161 62856167 7 + 2.364 2.328 -0.121
ENSG00000168003 E011 711.831617 1.138081e-04 2.137881e-02 5.438928e-02 11 62856168 62856381 214 + 2.836 2.809 -0.089
ENSG00000168003 E012 1.362940 1.101585e-02 1.515861e-01 2.638218e-01 11 62856382 62856453 72 + 0.158 0.429 1.940
ENSG00000168003 E013 293.921516 1.704755e-04 3.306609e-01 4.742643e-01 11 62870745 62870795 51 + 2.445 2.430 -0.050
ENSG00000168003 E014 274.002652 1.640143e-04 1.256670e-01 2.280955e-01 11 62870796 62870837 42 + 2.422 2.393 -0.096
ENSG00000168003 E015 547.926627 1.193598e-04 1.845695e-01 3.069386e-01 11 62871577 62871669 93 + 2.714 2.698 -0.051
ENSG00000168003 E016 57.447269 4.164275e-04 7.147447e-01 8.108623e-01 11 62876784 62876786 3 + 1.712 1.737 0.084
ENSG00000168003 E017 152.940257 2.338039e-04 3.466655e-01 4.907912e-01 11 62876787 62876879 93 + 2.126 2.162 0.120
ENSG00000168003 E018 2.180793 1.320164e-02 1.210972e-01 2.215050e-01 11 62879891 62879998 108 + 0.274 0.562 1.590
ENSG00000168003 E019 4.455261 1.885745e-02 1.104437e-05 7.265011e-05 11 62880342 62880600 259 + 0.000 0.859 12.453
ENSG00000168003 E020 16.253677 1.113567e-03 6.275452e-01 7.433429e-01 11 62880863 62880890 28 + 1.226 1.189 -0.129
ENSG00000168003 E021 16.884503 1.093260e-03 5.502192e-01 6.798681e-01 11 62880891 62880895 5 + 1.248 1.203 -0.160
ENSG00000168003 E022 678.344609 1.567109e-03 9.318926e-07 7.784139e-06 11 62880896 62881018 123 + 2.867 2.760 -0.355
ENSG00000168003 E023 1024.243730 3.077752e-04 2.076546e-11 4.103426e-10 11 62881019 62881056 38 + 3.032 2.946 -0.286
ENSG00000168003 E024 1291.627909 4.468861e-04 4.469608e-06 3.218373e-05 11 62881057 62881182 126 + 3.114 3.058 -0.188
ENSG00000168003 E025 886.280770 6.503286e-04 9.235677e-02 1.787951e-01 11 62881183 62881315 133 + 2.927 2.906 -0.069
ENSG00000168003 E026 1004.268219 2.168309e-03 6.507745e-01 7.617849e-01 11 62881316 62881447 132 + 2.952 2.974 0.074
ENSG00000168003 E027 3.152327 1.200837e-01 7.702698e-01 8.516419e-01 11 62881448 62881453 6 + 0.562 0.612 0.226
ENSG00000168003 E028 1.882120 9.556600e-03 2.969085e-01 4.381946e-01 11 62881698 62881698 1 + 0.561 0.388 -0.868
ENSG00000168003 E029 6.706458 2.523996e-03 3.398413e-01 4.837653e-01 11 62881699 62881718 20 + 0.928 0.816 -0.430
ENSG00000168003 E030 4.288701 4.525767e-03 6.171982e-01 7.350726e-01 11 62881719 62881721 3 + 0.732 0.665 -0.280
ENSG00000168003 E031 9.265695 5.773748e-02 7.619893e-01 8.457040e-01 11 62881722 62881758 37 + 0.929 0.986 0.215
ENSG00000168003 E032 12.368702 7.013814e-02 3.908747e-01 5.348217e-01 11 62881759 62881804 46 + 0.992 1.126 0.487
ENSG00000168003 E033 22.529093 2.436993e-02 2.656287e-01 4.036980e-01 11 62881805 62881880 76 + 1.249 1.374 0.438
ENSG00000168003 E034 26.384770 1.567592e-02 2.574934e-01 3.946137e-01 11 62881881 62881892 12 + 1.327 1.441 0.394
ENSG00000168003 E035 598.199190 6.012825e-04 9.100868e-01 9.468467e-01 11 62881893 62881900 8 + 2.737 2.743 0.019
ENSG00000168003 E036 1877.441572 5.697169e-05 2.520815e-03 8.825743e-03 11 62881901 62882066 166 + 3.251 3.231 -0.067
ENSG00000168003 E037 37.414947 1.013845e-02 2.048091e-01 3.321559e-01 11 62882067 62882504 438 + 1.608 1.519 -0.306
ENSG00000168003 E038 8.844505 1.955274e-03 3.403663e-01 4.843369e-01 11 62882505 62882529 25 + 1.028 0.928 -0.371
ENSG00000168003 E039 14.122758 2.498948e-02 6.798037e-01 7.838800e-01 11 62882530 62882618 89 + 1.178 1.138 -0.141
ENSG00000168003 E040 11.452269 1.495642e-03 7.756036e-01 8.554466e-01 11 62882619 62882666 48 + 1.079 1.056 -0.084
ENSG00000168003 E041 22.584935 1.779781e-02 3.475539e-01 4.917807e-01 11 62882667 62882774 108 + 1.386 1.303 -0.286
ENSG00000168003 E042 17.466117 1.498092e-02 1.077208e-01 2.021702e-01 11 62882775 62882807 33 + 1.327 1.172 -0.545
ENSG00000168003 E043 21.778526 2.382291e-03 1.779450e-02 4.669585e-02 11 62882808 62882907 100 + 1.430 1.253 -0.617
ENSG00000168003 E044 1826.312226 7.687217e-05 3.506534e-07 3.199145e-06 11 62882908 62882999 92 + 3.253 3.213 -0.133
ENSG00000168003 E045 64.259279 3.902020e-04 1.762725e-10 2.982166e-09 11 62883348 62883988 641 + 1.953 1.677 -0.932
ENSG00000168003 E046 24.669857 7.560091e-04 3.379078e-03 1.137631e-02 11 62883989 62884112 124 + 1.502 1.302 -0.691
ENSG00000168003 E047 46.690872 4.751741e-04 2.533505e-04 1.189209e-03 11 62884113 62884456 344 + 1.761 1.576 -0.629
ENSG00000168003 E048 1682.366160 8.810113e-05 1.187938e-02 3.324195e-02 11 62884457 62884525 69 + 3.202 3.185 -0.058
ENSG00000168003 E049 1450.893364 9.987656e-05 5.873719e-01 7.106689e-01 11 62884632 62884690 59 + 3.125 3.127 0.005
ENSG00000168003 E050 2431.373119 5.761315e-05 1.948209e-02 5.037635e-02 11 62885177 62885357 181 + 3.332 3.358 0.086
ENSG00000168003 E051 16.572495 2.593725e-03 2.257120e-02 5.686458e-02 11 62885358 62885464 107 + 1.335 1.146 -0.666
ENSG00000168003 E052 1921.498808 7.111227e-05 1.786961e-12 4.200178e-11 11 62885465 62885608 144 + 3.197 3.269 0.241
ENSG00000168003 E053 37.327382 5.553824e-04 1.552544e-01 2.687373e-01 11 62885609 62886196 588 + 1.603 1.526 -0.265
ENSG00000168003 E054 5.752617 1.133869e-02 4.496606e-01 5.908533e-01 11 62886437 62886440 4 + 0.732 0.845 0.450
ENSG00000168003 E055 9.142939 1.882181e-03 8.436406e-01 9.026560e-01 11 62886441 62886460 20 + 0.991 0.975 -0.059
ENSG00000168003 E056 15.500757 1.349630e-03 5.255257e-01 6.588749e-01 11 62886461 62886568 108 + 1.138 1.203 0.230
ENSG00000168003 E057 19.338981 5.258337e-03 8.017983e-01 8.737168e-01 11 62887870 62888100 231 + 1.289 1.274 -0.051
ENSG00000168003 E058 7.317148 2.434662e-03 4.314170e-01 5.739634e-01 11 62888101 62888112 12 + 0.950 0.861 -0.335
ENSG00000168003 E059 14.583364 1.421358e-03 8.563699e-01 9.111945e-01 11 62888113 62888134 22 + 1.165 1.154 -0.038
ENSG00000168003 E060 1221.217892 6.734142e-05 2.143037e-14 6.715050e-13 11 62888135 62888218 84 + 2.984 3.078 0.314
ENSG00000168003 E061 40.377910 8.487798e-04 3.307186e-01 4.743182e-01 11 62888219 62888330 112 + 1.617 1.567 -0.170
ENSG00000168003 E062 2571.037970 1.044274e-03 1.003328e-08 1.236598e-07 11 62888331 62888651 321 + 3.303 3.406 0.345
ENSG00000168003 E063 1082.262726 2.022762e-03 5.049358e-06 3.590248e-05 11 62888652 62888880 229 + 2.913 3.036 0.408