ENSG00000168002

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301788 ENSG00000168002 HEK293_OSMI2_2hA HEK293_TMG_2hB POLR2G protein_coding protein_coding 327.589 578.0377 182.4433 14.57739 1.925291 -1.663661 291.4948 521.6432 155.3245 11.09863 2.911238 -1.747713 0.882225 0.9026 0.8512 -0.0514 8.643458e-05 8.196573e-11 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000168002 E001 0.8126288 1.936036e-01 4.108955e-01 5.544762e-01 11 62761226 62761257 32 + 0.001 0.233 9.250
ENSG00000168002 E002 120.8201479 1.313093e-02 6.913965e-01 7.928849e-01 11 62761499 62761564 66 + 2.000 1.974 -0.088
ENSG00000168002 E003 203.8449225 5.878862e-03 4.779305e-01 6.163925e-01 11 62761565 62761579 15 + 2.229 2.198 -0.102
ENSG00000168002 E004 211.4981151 5.810569e-03 5.951504e-01 7.172895e-01 11 62761580 62761582 3 + 2.238 2.216 -0.073
ENSG00000168002 E005 740.3585266 1.279447e-03 1.546246e-08 1.839737e-07 11 62761583 62761602 20 + 2.861 2.737 -0.411
ENSG00000168002 E006 1060.4134726 7.766013e-04 1.028758e-02 2.947375e-02 11 62761603 62761614 12 + 2.953 2.911 -0.142
ENSG00000168002 E007 1079.6070177 7.921890e-04 8.777969e-03 2.572808e-02 11 62761615 62761616 2 + 2.962 2.918 -0.145
ENSG00000168002 E008 1365.1878470 4.189109e-04 8.392777e-02 1.656944e-01 11 62761617 62761636 20 + 3.046 3.024 -0.071
ENSG00000168002 E009 1617.8756213 9.511925e-05 5.890642e-01 7.121707e-01 11 62761637 62761660 24 + 3.103 3.101 -0.007
ENSG00000168002 E010 48.1612912 2.812741e-03 7.124165e-04 2.943303e-03 11 62761661 62761794 134 + 1.740 1.534 -0.701
ENSG00000168002 E011 2561.8661234 5.216211e-04 1.617288e-01 2.773768e-01 11 62761795 62761904 110 + 3.313 3.299 -0.046
ENSG00000168002 E012 98.8286235 3.945561e-03 2.379123e-12 5.489193e-11 11 62761905 62762184 280 + 2.141 1.803 -1.133
ENSG00000168002 E013 118.3900480 3.348593e-04 1.927145e-24 1.997220e-22 11 62762185 62762541 357 + 2.232 1.872 -1.206
ENSG00000168002 E014 202.7730082 1.896757e-04 1.591605e-20 1.083452e-18 11 62762542 62762742 201 + 2.397 2.141 -0.857
ENSG00000168002 E015 92.1685793 3.398788e-04 3.429084e-11 6.537483e-10 11 62762743 62762753 11 + 2.067 1.800 -0.899
ENSG00000168002 E016 202.2834145 8.133544e-03 4.674261e-04 2.035408e-03 11 62762754 62762866 113 + 2.339 2.166 -0.579
ENSG00000168002 E017 3427.5413986 5.902308e-05 1.208247e-01 2.211261e-01 11 62762867 62763026 160 + 3.414 3.430 0.053
ENSG00000168002 E018 2506.8350458 3.647082e-04 3.224098e-01 4.657052e-01 11 62765182 62765232 51 + 3.279 3.296 0.055
ENSG00000168002 E019 2555.5841831 9.385353e-04 4.714571e-01 6.105667e-01 11 62765340 62765405 66 + 3.288 3.304 0.055
ENSG00000168002 E020 2762.0977113 4.196623e-04 3.820781e-04 1.705463e-03 11 62765653 62765724 72 + 3.296 3.344 0.160
ENSG00000168002 E021 2019.7322578 1.181665e-04 7.666318e-14 2.217345e-12 11 62766243 62766276 34 + 3.127 3.213 0.287
ENSG00000168002 E022 2017.1010194 1.588566e-03 1.146168e-06 9.398695e-06 11 62766494 62766715 222 + 3.111 3.217 0.354