ENSG00000167996

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000526640 ENSG00000167996 HEK293_OSMI2_2hA HEK293_TMG_2hB FTH1 protein_coding protein_coding 1505.013 2695.902 952.6889 114.4386 20.06783 -1.500681 111.6471 202.6064 71.9111 20.41836 7.528432 -1.4942636 0.0709625 0.07483333 0.07523333 0.000400000 1.00000000 3.24251e-07 FALSE TRUE
ENST00000530019 ENSG00000167996 HEK293_OSMI2_2hA HEK293_TMG_2hB FTH1 protein_coding protein_coding 1505.013 2695.902 952.6889 114.4386 20.06783 -1.500681 349.1956 496.4275 284.3910 110.98276 14.518187 -0.8036853 0.2368292 0.18266667 0.29833333 0.115666667 0.14549948 3.24251e-07 FALSE FALSE
ENST00000620041 ENSG00000167996 HEK293_OSMI2_2hA HEK293_TMG_2hB FTH1 protein_coding protein_coding 1505.013 2695.902 952.6889 114.4386 20.06783 -1.500681 653.8988 1285.7814 359.9866 62.70600 12.679448 -1.8366014 0.4403875 0.47803333 0.37790000 -0.100133333 0.04858113 3.24251e-07 FALSE TRUE
MSTRG.5584.9 ENSG00000167996 HEK293_OSMI2_2hA HEK293_TMG_2hB FTH1 protein_coding   1505.013 2695.902 952.6889 114.4386 20.06783 -1.500681 272.0982 483.2839 177.8917 16.51354 5.916432 -1.4418200 0.1822208 0.17970000 0.18703333 0.007333333 0.87510428 3.24251e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167996 E001 1.995013 0.0169061050 4.505205e-02 1.002913e-01 11 61959718 61959821 104 - 0.666 0.312 -1.790
ENSG00000167996 E002 5.274542 0.0049659941 6.397012e-02 1.333052e-01 11 61959822 61959904 83 - 0.917 0.653 -1.055
ENSG00000167996 E003 1.208317 0.0108682123 5.833346e-01 7.074650e-01 11 61959905 61959927 23 - 0.206 0.312 0.793
ENSG00000167996 E004 94.762812 0.0063664670 5.008020e-01 6.370216e-01 11 61964285 61964565 281 - 1.917 1.873 -0.149
ENSG00000167996 E005 125.138220 0.0027417347 1.133326e-03 4.415439e-03 11 61964566 61964584 19 - 1.874 2.027 0.514
ENSG00000167996 E006 382.832402 0.0013528228 1.089234e-02 3.090723e-02 11 61964585 61964600 16 - 2.428 2.497 0.229
ENSG00000167996 E007 8076.700223 0.0022749933 2.348646e-06 1.799135e-05 11 61964601 61964746 146 - 3.722 3.822 0.333
ENSG00000167996 E008 11556.116772 0.0014303983 1.229589e-06 1.001729e-05 11 61964747 61964837 91 - 3.897 3.974 0.257
ENSG00000167996 E009 9480.764929 0.0018044530 8.001888e-05 4.279276e-04 11 61964838 61964891 54 - 3.815 3.887 0.238
ENSG00000167996 E010 26.261952 0.0009218665 2.496190e-03 8.751999e-03 11 61964892 61964986 95 - 1.520 1.291 -0.792
ENSG00000167996 E011 5889.905815 0.0012563842 7.464929e-05 4.025414e-04 11 61964987 61964988 2 - 3.616 3.679 0.211
ENSG00000167996 E012 14075.459609 0.0011840430 1.085728e-03 4.255023e-03 11 61964989 61965105 117 - 4.011 4.054 0.142
ENSG00000167996 E013 7626.437194 0.0010812528 5.685790e-01 6.952218e-01 11 61965106 61965112 7 - 3.778 3.780 0.006
ENSG00000167996 E014 42.790104 0.0077137072 5.885732e-04 2.491752e-03 11 61965113 61965368 256 - 1.734 1.487 -0.844
ENSG00000167996 E015 13237.052671 0.0004953810 7.483036e-02 1.512567e-01 11 61965369 61965515 147 - 4.040 4.014 -0.086
ENSG00000167996 E016 46.661812 0.0011477322 2.947125e-07 2.731793e-06 11 61965516 61965577 62 - 1.798 1.498 -1.019
ENSG00000167996 E017 25.830025 0.0080458015 1.061676e-06 8.761217e-06 11 61966989 61967311 323 - 1.619 1.212 -1.407
ENSG00000167996 E018 7263.389660 0.0010889235 1.150937e-05 7.542083e-05 11 61967312 61967371 60 - 3.820 3.742 -0.259
ENSG00000167996 E019 5222.659993 0.0030308951 2.613748e-04 1.222169e-03 11 61967372 61967401 30 - 3.698 3.593 -0.349
ENSG00000167996 E020 5273.924987 0.0066356406 1.151796e-02 3.239133e-02 11 61967402 61967453 52 - 3.702 3.597 -0.351
ENSG00000167996 E021 2936.973868 0.0096915782 8.540311e-02 1.680624e-01 11 61967454 61967457 4 - 3.435 3.346 -0.296
ENSG00000167996 E022 5676.382167 0.0090280583 3.303970e-03 1.116033e-02 11 61967458 61967547 90 - 3.759 3.621 -0.459
ENSG00000167996 E023 3875.450760 0.0113329385 1.971371e-03 7.136966e-03 11 61967548 61967634 87 - 3.613 3.449 -0.545