ENSG00000167972

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301732 ENSG00000167972 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCA3 protein_coding protein_coding 19.67656 22.30233 16.46934 1.604552 0.67673 -0.4371829 15.391687 17.613295 14.3988223 1.6732077 0.5761140 -0.2905312 0.7780958 0.78706667 0.87456667 0.08750000 0.04955304 0.04955304 FALSE  
ENST00000566200 ENSG00000167972 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCA3 protein_coding retained_intron 19.67656 22.30233 16.46934 1.604552 0.67673 -0.4371829 1.285803 1.173145 0.7011753 0.1343089 0.0743212 -0.7343495 0.0652125 0.05243333 0.04236667 -0.01006667 0.60712191 0.04955304 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167972 E001 2.502360 0.0058572588 2.950229e-01 4.361321e-01 16 2275771 2275880 110 - 0.410 0.599 0.920
ENSG00000167972 E002 109.367520 0.0038582928 3.523778e-11 6.706543e-10 16 2275881 2275991 111 - 1.777 2.122 1.161
ENSG00000167972 E003 160.027778 0.0072710129 1.745326e-08 2.058053e-07 16 2275992 2276053 62 - 1.960 2.280 1.071
ENSG00000167972 E004 695.177201 0.0066097217 7.487844e-11 1.347644e-09 16 2276054 2276805 752 - 2.624 2.909 0.947
ENSG00000167972 E005 203.186187 0.0073554096 3.432139e-04 1.552996e-03 16 2277597 2277670 74 - 2.151 2.355 0.680
ENSG00000167972 E006 277.536078 0.0054660309 7.876321e-05 4.221539e-04 16 2277879 2278069 191 - 2.295 2.486 0.639
ENSG00000167972 E007 93.673799 0.0038816382 5.325776e-02 1.149444e-01 16 2278288 2278294 7 - 1.880 1.996 0.387
ENSG00000167972 E008 256.867472 0.0006791344 2.127643e-06 1.645072e-05 16 2278295 2278458 164 - 2.295 2.439 0.480
ENSG00000167972 E009 273.576446 0.0001721313 6.202724e-09 7.956985e-08 16 2278943 2279130 188 - 2.313 2.467 0.512
ENSG00000167972 E010 264.643545 0.0001784049 2.063635e-05 1.276111e-04 16 2281027 2281221 195 - 2.322 2.441 0.395
ENSG00000167972 E011 89.612781 0.0003396815 5.515614e-01 6.810069e-01 16 2281381 2281392 12 - 1.906 1.949 0.142
ENSG00000167972 E012 160.692046 0.0024417267 1.259203e-02 3.495168e-02 16 2281393 2281505 113 - 2.107 2.224 0.390
ENSG00000167972 E013 82.781399 0.0055880634 1.347538e-02 3.702494e-02 16 2281506 2281509 4 - 1.791 1.950 0.538
ENSG00000167972 E014 190.440500 0.0001997633 3.916841e-03 1.290988e-02 16 2283186 2283358 173 - 2.196 2.294 0.326
ENSG00000167972 E015 12.794576 0.0013745459 4.377782e-01 5.796664e-01 16 2283359 2283972 614 - 1.156 1.101 -0.199
ENSG00000167972 E016 172.218406 0.0005282779 7.291126e-01 8.213836e-01 16 2284279 2284437 159 - 2.202 2.231 0.098
ENSG00000167972 E017 188.886331 0.0002422702 3.323127e-01 4.759488e-01 16 2284779 2284998 220 - 2.231 2.276 0.151
ENSG00000167972 E018 180.674455 0.0002681331 4.157406e-01 5.590988e-01 16 2285442 2285646 205 - 2.213 2.255 0.139
ENSG00000167972 E019 225.639227 0.0001722847 2.710823e-01 4.097803e-01 16 2286694 2286967 274 - 2.340 2.332 -0.026
ENSG00000167972 E020 236.232555 0.0038391287 7.264196e-01 8.194328e-01 16 2288026 2288329 304 - 2.351 2.358 0.025
ENSG00000167972 E021 4.382377 0.0038027709 8.943569e-01 9.364833e-01 16 2289048 2289433 386 - 0.692 0.726 0.140
ENSG00000167972 E022 180.540092 0.0017384495 9.987744e-01 1.000000e+00 16 2289434 2289620 187 - 2.226 2.247 0.067
ENSG00000167972 E023 139.152504 0.0002474479 4.836786e-02 1.062763e-01 16 2292140 2292238 99 - 2.150 2.108 -0.141
ENSG00000167972 E024 148.764556 0.0003321362 1.370594e-01 2.439963e-01 16 2295590 2295740 151 - 2.168 2.142 -0.088
ENSG00000167972 E025 165.733539 0.0016876569 2.327560e-02 5.832277e-02 16 2297329 2297539 211 - 2.234 2.178 -0.187
ENSG00000167972 E026 148.884387 0.0002959679 2.516980e-03 8.814431e-03 16 2297766 2297921 156 - 2.197 2.125 -0.240
ENSG00000167972 E027 149.676075 0.0021264563 6.089996e-04 2.565958e-03 16 2298386 2298540 155 - 2.222 2.117 -0.352
ENSG00000167972 E028 126.791909 0.0003239295 5.410509e-06 3.821080e-05 16 2299403 2299532 130 - 2.162 2.035 -0.428
ENSG00000167972 E029 113.032778 0.0002726171 1.183025e-05 7.729360e-05 16 2300005 2300148 144 - 2.115 1.986 -0.432
ENSG00000167972 E030 138.591343 0.0057696978 1.645339e-04 8.115402e-04 16 2303969 2304150 182 - 2.220 2.063 -0.524
ENSG00000167972 E031 140.843613 0.0022689487 4.466779e-11 8.358533e-10 16 2308450 2308623 174 - 2.262 2.037 -0.751
ENSG00000167972 E032 106.792936 0.0040186810 1.216538e-07 1.216005e-06 16 2317283 2317403 121 - 2.141 1.921 -0.737
ENSG00000167972 E033 93.166538 0.0002886258 6.558124e-10 1.006821e-08 16 2317648 2317764 117 - 2.074 1.866 -0.700
ENSG00000167972 E034 132.009757 0.0024769517 6.853140e-07 5.895767e-06 16 2319581 2319840 260 - 2.204 2.033 -0.573
ENSG00000167972 E035 10.536088 0.0020311509 9.934778e-05 5.188085e-04 16 2323339 2323522 184 - 0.692 1.169 1.812
ENSG00000167972 E036 130.726705 0.0044683182 4.817723e-04 2.090431e-03 16 2323523 2323688 166 - 2.180 2.046 -0.447
ENSG00000167972 E037 90.223549 0.0192496879 3.066548e-02 7.326510e-02 16 2324404 2324488 85 - 2.021 1.888 -0.447
ENSG00000167972 E038 78.918120 0.0110816696 9.870295e-04 3.914541e-03 16 2324489 2324531 43 - 1.994 1.807 -0.630
ENSG00000167972 E039 182.060820 0.0025091226 4.080778e-10 6.499295e-09 16 2326010 2326274 265 - 2.359 2.160 -0.666
ENSG00000167972 E040 85.109421 0.0003050216 5.980794e-11 1.093988e-09 16 2326413 2326473 61 - 2.048 1.815 -0.782
ENSG00000167972 E041 70.141206 0.0004393360 2.745710e-09 3.756257e-08 16 2326474 2326492 19 - 1.967 1.734 -0.786
ENSG00000167972 E042 188.870262 0.0052384893 5.767662e-07 5.042998e-06 16 2328453 2328757 305 - 2.371 2.180 -0.640
ENSG00000167972 E043 101.383409 0.0063161054 2.132760e-07 2.033647e-06 16 2329648 2329854 207 - 2.131 1.884 -0.827
ENSG00000167972 E044 4.277084 0.0044298701 2.283338e-01 3.604402e-01 16 2339192 2339241 50 - 0.573 0.768 0.824
ENSG00000167972 E045 28.364508 0.0118692556 1.293897e-06 1.049291e-05 16 2340573 2340746 174 - 1.649 1.266 -1.319