ENSG00000167971

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343516 ENSG00000167971 HEK293_OSMI2_2hA HEK293_TMG_2hB CASKIN1 protein_coding protein_coding 2.50464 2.938404 2.209052 0.340757 0.06489107 -0.4099911 1.7545476 2.5648604 1.1849118 0.29033584 0.01617201 -1.1075900 0.68085000 0.87353333 0.5370667 -0.33646667 3.233459e-09 3.233459e-09 FALSE TRUE
ENST00000562055 ENSG00000167971 HEK293_OSMI2_2hA HEK293_TMG_2hB CASKIN1 protein_coding retained_intron 2.50464 2.938404 2.209052 0.340757 0.06489107 -0.4099911 0.2147019 0.1024306 0.5993064 0.05955612 0.05644607 2.4381331 0.08940833 0.03353333 0.2704333 0.23690000 3.624098e-06 3.233459e-09 FALSE FALSE
MSTRG.11845.3 ENSG00000167971 HEK293_OSMI2_2hA HEK293_TMG_2hB CASKIN1 protein_coding   2.50464 2.938404 2.209052 0.340757 0.06489107 -0.4099911 0.3791340 0.2711132 0.4248334 0.06018978 0.03784593 0.6293116 0.17515000 0.09293333 0.1925667 0.09963333 1.009415e-01 3.233459e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167971 E001 69.854369 0.0223280851 6.409839e-03 1.968718e-02 16 2177180 2177834 655 - 1.639 1.879 0.810
ENSG00000167971 E002 34.175080 0.0006518965 3.212519e-05 1.896961e-04 16 2177835 2178010 176 - 1.279 1.576 1.025
ENSG00000167971 E003 24.179458 0.0008123095 3.096141e-06 2.309088e-05 16 2178011 2178165 155 - 1.046 1.451 1.431
ENSG00000167971 E004 21.419190 0.0010039765 3.576832e-02 8.313643e-02 16 2178166 2178394 229 - 1.178 1.361 0.642
ENSG00000167971 E005 22.273694 0.0008979850 3.565562e-01 5.009345e-01 16 2178395 2178646 252 - 1.269 1.351 0.288
ENSG00000167971 E006 18.532890 0.0071760185 8.399844e-01 9.000805e-01 16 2178902 2179325 424 - 1.248 1.244 -0.016
ENSG00000167971 E007 45.891464 0.0005246564 3.123866e-01 4.549382e-01 16 2179593 2180302 710 - 1.584 1.650 0.225
ENSG00000167971 E008 18.634583 0.0171999337 7.123932e-01 8.091524e-01 16 2180303 2180460 158 - 1.226 1.275 0.175
ENSG00000167971 E009 79.565700 0.0068115673 2.773301e-01 4.168864e-01 16 2180461 2181599 1139 - 1.811 1.888 0.258
ENSG00000167971 E010 26.706043 0.0007636584 2.524118e-02 6.236979e-02 16 2181791 2181898 108 - 1.496 1.356 -0.483
ENSG00000167971 E011 16.849142 0.0011728884 5.111986e-01 6.462886e-01 16 2181899 2181929 31 - 1.248 1.203 -0.161
ENSG00000167971 E012 16.627610 0.0138260378 3.315356e-01 4.751699e-01 16 2183646 2183747 102 - 1.269 1.184 -0.303
ENSG00000167971 E013 15.427272 0.0265100752 2.683184e-01 4.067610e-01 16 2183831 2183941 111 - 1.259 1.147 -0.397
ENSG00000167971 E014 23.901108 0.0132402220 9.258856e-02 1.791670e-01 16 2184777 2184868 92 - 1.451 1.318 -0.462
ENSG00000167971 E015 19.579543 0.0055094511 7.270304e-01 8.198953e-01 16 2184951 2185035 85 - 1.289 1.270 -0.066
ENSG00000167971 E016 23.066961 0.0009205356 9.548113e-01 9.756759e-01 16 2185111 2185199 89 - 1.336 1.342 0.022
ENSG00000167971 E017 19.645643 0.0010091511 6.855213e-01 7.882324e-01 16 2185307 2185408 102 - 1.248 1.291 0.152
ENSG00000167971 E018 25.943019 0.0012588236 1.138427e-02 3.208300e-02 16 2186707 2186824 118 - 1.496 1.333 -0.564
ENSG00000167971 E019 20.155683 0.0053016816 1.617747e-02 4.311431e-02 16 2186978 2187072 95 - 1.408 1.223 -0.648
ENSG00000167971 E020 20.154975 0.0009232960 3.505744e-02 8.175896e-02 16 2187166 2187274 109 - 1.385 1.234 -0.528
ENSG00000167971 E021 15.248964 0.0011684943 1.731743e-01 2.923173e-01 16 2187353 2187461 109 - 1.248 1.139 -0.387
ENSG00000167971 E022 2.513149 0.0058970542 1.213841e-03 4.687697e-03 16 2188897 2189026 130 - 0.798 0.293 -2.452
ENSG00000167971 E023 15.421555 0.0012424277 4.733670e-01 6.123002e-01 16 2189027 2189157 131 - 1.214 1.161 -0.189
ENSG00000167971 E024 14.713496 0.0018623202 9.521142e-01 9.740209e-01 16 2189238 2189333 96 - 1.138 1.155 0.059
ENSG00000167971 E025 17.896872 0.0019417484 2.014670e-01 3.280062e-01 16 2189419 2189564 146 - 1.299 1.203 -0.337
ENSG00000167971 E026 16.086779 0.0031155737 4.214491e-03 1.374269e-02 16 2190073 2190170 98 - 1.344 1.108 -0.835
ENSG00000167971 E027 10.778848 0.0136947196 8.003765e-02 1.596114e-01 16 2190307 2190358 52 - 1.152 0.966 -0.677
ENSG00000167971 E028 7.767745 0.0036610481 1.180565e-02 3.306981e-02 16 2196339 2196605 267 - 1.079 0.800 -1.050