ENSG00000167971

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC	codingPotential

ENST00000343516	ENSG00000167971	HEK293_OSMI2_2hA	HEK293_TMG_2hB	CASKIN1	protein_coding	protein_coding	2.50464	2.938404	2.209052	0.340757	0.06489107	-0.4099911	1.7545476	2.5648604	1.1849118	0.29033584	0.01617201	-1.1075900	0.68085000	0.87353333	0.5370667	-0.33646667	3.233459e-09	3.233459e-09	FALSE	TRUE
ENST00000562055	ENSG00000167971	HEK293_OSMI2_2hA	HEK293_TMG_2hB	CASKIN1	protein_coding	retained_intron	2.50464	2.938404	2.209052	0.340757	0.06489107	-0.4099911	0.2147019	0.1024306	0.5993064	0.05955612	0.05644607	2.4381331	0.08940833	0.03353333	0.2704333	0.23690000	3.624098e-06	3.233459e-09	FALSE	FALSE
MSTRG.11845.3	ENSG00000167971	HEK293_OSMI2_2hA	HEK293_TMG_2hB	CASKIN1	protein_coding		2.50464	2.938404	2.209052	0.340757	0.06489107	-0.4099911	0.3791340	0.2711132	0.4248334	0.06018978	0.03784593	0.6293116	0.17515000	0.09293333	0.1925667	0.09963333	1.009415e-01	3.233459e-09	FALSE	TRUE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

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featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
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width
strand
HEK293_TMG_2hB
HEK293_OSMI2_2hA
log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_2hB	HEK293_OSMI2_2hA	log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB

ENSG00000167971	E001	69.854369	0.0223280851	6.409839e-03	1.968718e-02	16	2177180	2177834	655	-	1.639	1.879	0.810
ENSG00000167971	E002	34.175080	0.0006518965	3.212519e-05	1.896961e-04	16	2177835	2178010	176	-	1.279	1.576	1.025
ENSG00000167971	E003	24.179458	0.0008123095	3.096141e-06	2.309088e-05	16	2178011	2178165	155	-	1.046	1.451	1.431
ENSG00000167971	E004	21.419190	0.0010039765	3.576832e-02	8.313643e-02	16	2178166	2178394	229	-	1.178	1.361	0.642
ENSG00000167971	E005	22.273694	0.0008979850	3.565562e-01	5.009345e-01	16	2178395	2178646	252	-	1.269	1.351	0.288
ENSG00000167971	E006	18.532890	0.0071760185	8.399844e-01	9.000805e-01	16	2178902	2179325	424	-	1.248	1.244	-0.016
ENSG00000167971	E007	45.891464	0.0005246564	3.123866e-01	4.549382e-01	16	2179593	2180302	710	-	1.584	1.650	0.225
ENSG00000167971	E008	18.634583	0.0171999337	7.123932e-01	8.091524e-01	16	2180303	2180460	158	-	1.226	1.275	0.175
ENSG00000167971	E009	79.565700	0.0068115673	2.773301e-01	4.168864e-01	16	2180461	2181599	1139	-	1.811	1.888	0.258
ENSG00000167971	E010	26.706043	0.0007636584	2.524118e-02	6.236979e-02	16	2181791	2181898	108	-	1.496	1.356	-0.483
ENSG00000167971	E011	16.849142	0.0011728884	5.111986e-01	6.462886e-01	16	2181899	2181929	31	-	1.248	1.203	-0.161
ENSG00000167971	E012	16.627610	0.0138260378	3.315356e-01	4.751699e-01	16	2183646	2183747	102	-	1.269	1.184	-0.303
ENSG00000167971	E013	15.427272	0.0265100752	2.683184e-01	4.067610e-01	16	2183831	2183941	111	-	1.259	1.147	-0.397
ENSG00000167971	E014	23.901108	0.0132402220	9.258856e-02	1.791670e-01	16	2184777	2184868	92	-	1.451	1.318	-0.462
ENSG00000167971	E015	19.579543	0.0055094511	7.270304e-01	8.198953e-01	16	2184951	2185035	85	-	1.289	1.270	-0.066
ENSG00000167971	E016	23.066961	0.0009205356	9.548113e-01	9.756759e-01	16	2185111	2185199	89	-	1.336	1.342	0.022
ENSG00000167971	E017	19.645643	0.0010091511	6.855213e-01	7.882324e-01	16	2185307	2185408	102	-	1.248	1.291	0.152
ENSG00000167971	E018	25.943019	0.0012588236	1.138427e-02	3.208300e-02	16	2186707	2186824	118	-	1.496	1.333	-0.564
ENSG00000167971	E019	20.155683	0.0053016816	1.617747e-02	4.311431e-02	16	2186978	2187072	95	-	1.408	1.223	-0.648
ENSG00000167971	E020	20.154975	0.0009232960	3.505744e-02	8.175896e-02	16	2187166	2187274	109	-	1.385	1.234	-0.528
ENSG00000167971	E021	15.248964	0.0011684943	1.731743e-01	2.923173e-01	16	2187353	2187461	109	-	1.248	1.139	-0.387
ENSG00000167971	E022	2.513149	0.0058970542	1.213841e-03	4.687697e-03	16	2188897	2189026	130	-	0.798	0.293	-2.452
ENSG00000167971	E023	15.421555	0.0012424277	4.733670e-01	6.123002e-01	16	2189027	2189157	131	-	1.214	1.161	-0.189
ENSG00000167971	E024	14.713496	0.0018623202	9.521142e-01	9.740209e-01	16	2189238	2189333	96	-	1.138	1.155	0.059
ENSG00000167971	E025	17.896872	0.0019417484	2.014670e-01	3.280062e-01	16	2189419	2189564	146	-	1.299	1.203	-0.337
ENSG00000167971	E026	16.086779	0.0031155737	4.214491e-03	1.374269e-02	16	2190073	2190170	98	-	1.344	1.108	-0.835
ENSG00000167971	E027	10.778848	0.0136947196	8.003765e-02	1.596114e-01	16	2190307	2190358	52	-	1.152	0.966	-0.677
ENSG00000167971	E028	7.767745	0.0036610481	1.180565e-02	3.306981e-02	16	2196339	2196605	267	-	1.079	0.800	-1.050

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000167971

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3